Cardiovascular Effects of Tramadol in Dogs Anesthetized with Sevoflurane
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概要
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Cardiovascular effects of tramadol were evaluated in dogs anesthetized with sevoflurane. Six beagle dogs were anesthetized twice at 7 days interval. The minimum alveolar concentration (MAC) of sevoflurane was earlier determined in each dog. The dogs were then anesthetized with sevoflurane at 1.3 times of predetermined individual MAC and cardiovascular parameters were evaluated before (baseline) and after an intravenous injection of tramadol (4 mg/kg). The administration of tramadol produced a transient and mild increase in arterial blood pressure (ABP) (P=0.004) with prolonged increase in systemic vascular resistance (SVR) (P<0.0001). Compared with baseline value, mean ABP increased significantly at 5 min (119% of baseline value, P=0.003), 10 min (113%, P=0.027), and 15 min (111%, P=0.022). SVR also increased significantly at 5 min (128%, P<0.0001), 10 min (121%, P=0.026), 30 min (114%, P=0.025), 45 min (113%, P=0.025) and 60 min (112%, P=0.048). Plasma concentrations of tramadol were weakly correlated with the percentage changes in mean ABP (r=0.642, P<0.0001) and SVR (r=0.646, P<0.0001). There was no significant change in heart rate, cardiac output, cardiac index, stroke volume, pulmonary arterial pressure, right atrial pressure and pulmonary capillary wedge pressure. In conclusion, the administration of tramadol produces a prolonged peripheral vascular constriction in dogs anesthetized with sevoflurane, which is accompanied with a transient and mild increase in arterial blood pressure. It also indicated that the degree of vasoconstriction might depend on the plasma concentration of tramadol.
著者
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Umar Mohammed
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen Universit
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ITAMI Takaharu
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen Universit
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Yamashita Kazuto
Department Of First Veterinary Surgery Rakuno-gakuen University
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Inoue Hiroki
Department Of Biological Sciences Graduate School Of Science Osaka University
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Tamura Jun
Department Of Surgery Otsu Red Cross Hospital
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MIYOSHI Kenjirou
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen Universit
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TAMARU Naomichi
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen Universit
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KAWASE Kodai
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen Universit
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ISHIZUKA Tomohito
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen Universit
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UMAR Mohammed
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Faculty of Environment Systems, Rakuno Gakuen University
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Tamura Jun
Department of Chemistry, Tokyo Institute of Technology
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TAMURA Jun
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University
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ITAMI Takaharu
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University
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ITAMI Takaharu
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Faculty of Environment Systems, Rakuno Gakuen University
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KAWASE Kodai
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University
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YAMASHITA Kazuto
Department of Companion Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University
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