Effects of a Single Bolus Intravenous Dose of Tramadol on Minimum Alveolar Concentration (MAC) of Sevoflurane in Dogs
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概要
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Tramadol is an atypical opioid analgesic widely used in small animal practice. This study was designed to determine the effect of a single intravenous (IV) dose of tramadol on the minimum alveolar concentration (MAC) of sevoflurane in dogs. Six beagle dogs were anesthetized twice to determine the sevoflurane MAC with or without an administration of tramadol (4 mg/kg, IV) at 7 days interval. The sevoflurane MAC was determined using a tail clamp method in each dog ventilated with positive pressure ventilation. The tramadol administration produced a significant reduction in the sevoflurane MAC by 22.3 ± 12.2% (1.44 ± 0.28% with tramadol versus 1.86 ± 0.30% without tramadol, P=0.010). This MAC reduction had been determined from 122 ± 19 to 180 ± 41 min following the tramadol administration. During this period, the plasma concentrations of tramadol and its metabolite, O-desmethyltramadol (M1), decreased from 429 ± 64 to 332 ± 55 ng/ml and from 136 ± 24 to 114 ± 68 ng/ml, respectively, but these changes were not statistically significant. There was no significant difference in heart rate, mean arterial blood pressure and SpO2 between the control and tramadol treatment. The dogs that received tramadol treatment sometimes breathed spontaneously. Therefore, their respiratory rates significantly increased, and PETCO2 decreased during the MAC determination. In conclusion, the single IV dose of tramadol produced a significant reduction in the sevoflurane MAC in dogs.
- 公益社団法人 日本獣医学会の論文
著者
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ITAMI Takaharu
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen Universit
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Yamashita Kazuto
Department Of First Veterinary Surgery Rakuno-gakuen University
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Inoue Hiroki
Department Of Biological Sciences Graduate School Of Science Osaka University
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MIYOSHI Kenjirou
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen Universit
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TAMARU Naomichi
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen Universit
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KAWASE Kodai
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen Universit
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ISHIZUKA Tomohito
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen Universit
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UMAR Mohammed
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Faculty of Environment Systems, Rakuno Gakuen University
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Tamura Jun
Department of Chemistry, Tokyo Institute of Technology
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ITAMI Takaharu
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Faculty of Environment Systems, Rakuno Gakuen University
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UMAR Mohammed
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069–8501, Japan
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KAWASE Kodai
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069–8501, Japan
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YAMASHITA Kazuto
Department of Companion Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University
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TAMARU Naomichi
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069–8501, Japan
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