Anesthetic and Cardio-Respiratory Effects of Propofol, Medetomidine, Lidocaine, Butorphanol Total Intravenous Anesthesia in Horses
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概要
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Anesthetic and cardio-respiratory effects of medetomidine, lidocaine, butorphanol and propofol total intravenous anesthesia (MLBP-TIVA) were evaluated in horses undergoing an experimental surgery. Ten horses were pre-medicated with an intravenous injection (IV) of medetomidine (5 μg/kg) and butorphanol (20 μg/kg). Anesthesia was induced by administration of 1% propofol (3 mg/kg, IV) at a rate of 1 mg/kg/min (n=5, group-1) or 2% propofol administered at a rate of 6 mg/kg/min (n=5, group-2) following administration of lidocaine (1 mg/kg, IV) and then maintained by infusions of propofol, medetomidine (3.5 μg/kg/hr), lidocaine (3 mg/kg/hr) and butorphanol (24 μg/kg/hr). The mean durations of anesthesia and propofol infusion rate required for maintaining surgical anesthesia were 130 ± 17 min and 0.10 ± 0.01 mg/kg/min in group-1 and 129 ± 14 min and 0.10 ± 0.02 mg/kg/min in group-2. Four in group-1 and 2 horses of group-2 paddled following recumbency during induction of anesthesia. The median quality scores (0: poor–4: excellent) for induction were 3 and for recovery (0: unable to stand–5: excellent) were 4 for both groups. During transition to anesthesia (the first 20-min period after the induction), it was uneventful in group-2 while all horses showed a light plane of anesthesia in group-1. The quality score (0: poor–3: excellent) for the transition to anesthesia in group-2 was significantly higher than in group-1 (median 3 versus 1, P=0.009). Heart rate and arterial blood pressure were maintained within acceptable ranges but hypercapnea occurred during anesthesia in both groups. In conclusion, MLBP-TIVA may provide clinically useful surgical anesthesia in horses. A rapid induction with propofol may improve the qualities of induction and transition to MLBP-TIVA
著者
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ITAMI Takaharu
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen Universit
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SAITOH Yasuo
Department of Chemistry, University of Tsukuba
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Yamashita Kazuto
Department Of First Veterinary Surgery Rakuno-gakuen University
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MIYOSHI Kenjirou
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen Universit
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ISHIZUKA Tomohito
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen Universit
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UMAR Mohammed
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Faculty of Environment Systems, Rakuno Gakuen University
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Tamura Jun
Department of Chemistry, Tokyo Institute of Technology
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TAMURA Jun
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069–8501, Japan
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SAITOH Motoaki
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069–8501, Japan
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MUIR William
The Animal Medical Center, New York, NY 10065, U.S.A.
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ITAMI Takaharu
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069–8501, Japan
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ITAMI Takaharu
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Faculty of Environment Systems, Rakuno Gakuen University
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UMAR Mohammed
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069–8501, Japan
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YAMASHITA Kazuto
Department of Companion Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University
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ISHIZUKA Tomohito
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069–8501, Japan
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