Minimum Alveolar Concentration for Blunting Adrenergic Responses (MAC-BAR) of Sevoflurane in Dogs
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概要
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It is well known that heart rate or arterial blood pressure may increase in response to surgical stimulation despite the absence of a purposeful movement. However, there is limited information regarding anesthetic requirement for blunting adrenergic response in dogs. This study was designed to compare the minimum alveolar concentrations of sevoflurane required to prevent autonomic response (MAC-BAR) and purposeful movement (MAC) in dogs. Sevoflurane MAC-BAR and MAC were determined in 5 beagle dogs by judging dogs response to a noxious electrical stimulus applied to the gingiva. The sevoflurane MAC-BAR was significantly higher than MAC (3.33 ± 0.48% vs 2.10 ± 0.28%, P=0.005). These results suggested that autonomic responses occurred at sevoflurane anesthetic concentrations at which purposeful movements were absent.
著者
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Yamashita Kazuto
Department Of First Veterinary Surgery Rakuno-gakuen University
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MIYOSHI Kenjirou
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen Universit
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ISHIZUKA Tomohito
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen Universit
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Tamura Jun
Department of Chemistry, Tokyo Institute of Technology
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ITAMI Takaharu
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Faculty of Environment Systems, Rakuno Gakuen University
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ITAMI Takaharu
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido 069-8501, Japan
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FURUKAWA Erika
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido 069-8501, Japan
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TAMURA Jun
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido 069-8501, Japan
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YAMASHITA Kazuto
Department of Companion Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University
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ISHIZUKA Tomohito
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido 069-8501, Japan
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