Formal Synthesis of Squalamine from Desmosterol

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概要

• 論文の詳細を見る

• The key intermediate to squalamine, (5α, 7α, 24R) -7, 24-dihydroxy-cholestan-3-one, was synthesized from the 3-O-acetyl-24R, 25-dihydroxy derivative of desmosterol via 10 steps in 16% overall yield and squalamine was also prepared via two further steps in 7.4% total yield from the desmosterol derivative.

• 社団法人日本薬学会の論文
• 2003-10-01

著者

• Ikekawa N

  Niigata University Of Pharmacy And Applied Life Sciences

• Takeuchi S

  Niigata University Of Pharmacy And Applied Life Sciences

• Takeuchi Seiji

  Niigata College Of Pharmacy

• OKUMURA Kazuo

  Niigata University of Pharmacy and Applied Life Sciences

• NAKAMURA Yutaka

  Niigata University of Pharmacy and Applied Life Sciences

• KATO Isao

  Nippon Fine Chemical Co. Ltd.

• FUJIMOTO Yoshinori

  Tokyo Institute of Technology

• IKEKAWA Nobuo

  Niigata University of Pharmacy and Applied Life Sciences

• Kato I

  Nippon Fine Chemical Co. Ltd.

• Nakamura Yutaka

  Niigata Univ. Of Pharmacy And Applied Life Sciences

• Ikekawa Nobuo

  Niigata College Of Pharmacy

関連論文

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