.BETA.1-Adrenoceptor-mediated amylase release and cyclic AMP accumulation in rat parotid gland tissue.
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概要
- 論文の詳細を見る
The present study was carried out to determine the relationship of β<SUB>1</SUB>-and β<SUB>2</SUB>-subtype to amylase release and cyclic AMP (cAM P) accumulation in rat parotid tissue. In in vitro experiments, β-adrenergic agents (isoproterenol and dobutamine)-induced amylase release and cAMP accumulation were all completely inhibited by the β<SUB>1</SUB>-antagonist metoprolol, but incompletely inhibited by the β<SUB>2</SUB>-antagonist butoxamine. The β<SUB>2</SUB>-agonist procaterol caused little or no amylase release or cAMP accumulation. Our results suggest that both amylase release and cAM P accumulation in rat parotid tissue may be selectively induced by β<SUB>1</SUB>-adrenergic stimulation.
- 公益社団法人 日本薬理学会の論文
著者
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Ohshika Hideyo
Department Of Pharmacology Sapporo Medical College
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Suzuki Yuko
Department Of Chemical And Biological Sciences Faculty Of Science Japan Women's University
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