H1foo is Indispensable for Meiotic Maturation of the Mouse Oocyte
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概要
- 論文の詳細を見る
Oocyte-specific linker histone H1foo is localized in the oocyte nucleus, either diffusely or bound to chromatin, during the processes of meiotic maturation and fertilization. This expression pattern suggests that H1foo plays a key role in the control of gene expression and chromatin modification during oogenesis and early embryogenesis. To reveal the function of H1foo, we microinjected antisense morpholino oligonucleotides (MO) against H1foo into mouse germinal-vesicle stage oocytes. The rate of in vitro maturation of the antisense MO group was significantly lower than that of the control group. Eggs that failed to extrude a first polar body following injection of antisense MO arrested at metaphase I. Additionally, co-injection of in vitro synthesized H1foo mRNA along with antisense MO successfully rescued expression of H1foo and improved the in vitro maturation rate. There was no difference in the rate of parthenogenesis between the antisense MO and control groups. These results indicate that H1foo is essential for maturation of germinal vesicle-stage oocytes.
- 日本繁殖生物学会の論文
- 2007-08-01
著者
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SAEKI Kazuhiro
Division of Biological and Science, Graduate School of Biology-Oriented Science and Technology, Kink
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HOSOI Yoshihiko
Division of Biological and Science, Graduate School of Biology-Oriented Science and Technology, Kink
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IRITANI Akira
Division of Biological and Science, Graduate School of Biology-Oriented Science and Technology, Kink
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MATSUMOTO Kazuya
Division of Biological and Science, Graduate School of Biology-Oriented Science and Technology, Kink
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TANAKA Mamoru
Department of Electrical and Electronics Engineering, Sophia University
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Iritani Akira
Division Of Biological And Science Graduate School Of Biology-oriented Science And Technology Kinki
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Yoshimura Yasunori
Department of Obstetrics and Gynecology, School of Medicine, Keio University
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Matsumoto Kazuya
Department Of Genetic Engineering Graduate School Of Biology Oriented Science And Technology Kinki U
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Tanaka Mamoru
Department Of Obstetrics And Gynecology Keio University School Of Medicine
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Iritani A
Division Of Biological And Science Graduate School Of Biology-oriented Science And Technology Kinki
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Iritani Akira
Laboratory Of Animal Reproduction Department Of Animal Science Kyoto University
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Saeki K
Department Of Genetic Engineering Graduate School Of Biology Oriented Science And Technology Kinki U
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FURUYA Masataka
Department of Obstetrics and Gynecology, Hiratsuka City Hospital
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Hosoi Y
Department Of Genetic Engineering Graduate School Of Biology Oriented Science And Technology Kinki U
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TERANISHI Takahide
Department of Obstetrics and Gynecology, Ota General Hospital
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ISHIMOTO Hitoshi
Department of Obstetrics and Gynecology, Keio University School of Medicine
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MINEGISHI Kazuhiro
Department of Obstetrics and Gynecology, Keio University School of Medicine
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Hosoi Yoshihiko
Department Of Genetic Engineering Graduate School Of Biology Oriented Science And Technology Kinki U
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Ishimoto Hitoshi
Department Of Obstetrics And Gynecology Tokai University School Of Medicine
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Teranishi Takahide
Department Of Obstetrics And Gynecology Ota General Hospital
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Yoshimura Yasunori
Department Of Obstetrics And Gynecology Keio University School Of Medicine
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Yoshimura Yasunori
Department Of Obstetrics And Gynecology Fujita-gakuen Health University School Of Medicine
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Minegishi Kazuhiro
Department Of Obstetrics And Gynecology Keio University School Of Medicine
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Matsumoto Kazuya
徳島大学医学部
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Miyakoshi Kei
Department Of Obstetrics And Gynecology Keio University School Of Medicine
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Furuya Masataka
Department Of Obstetrics And Gynecology Hiratsuka City Hospital
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Furuya Masataka
Department Of Obstetrics And Gynecology Keio University School Of Medicine
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Tanaka Mamoru
Department Of Electrical And Electronics Engineering Sophia University
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Tanaka Mamoru
Department Of Applied Chemistry Kobe City College Of Technology
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Hattori Yoshihisa
Department Of Obstetrics And Gynecology Keio University School Of Medicine
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Ishimoto Hitoshi
Department Of Internal Medicine Keio University School Of Medicine
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YOSHIMURA YASUNORI
Department of Obsterics and Gynaecology, School of Medicine, Keio University
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Yoshimura Yasunori
Department of Gynecology, School of Medicine, Keio University
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