Mouse Androgenetic Embryonic Stem Cells Differentiated to Multiple Cell Lineages in Three Embryonic Germ Layers In Vitro

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概要

• 論文の詳細を見る

• The embryos of some rodents and primates can precede early development without the process of fertilization; however, they cease to develop after implantation because of restricted expressions of imprinting genes. Asexually developed embryos are classified into parthenote/gynogenote and androgenote by their genomic origins. Embryonic stem cells (ESCs) derived from asexual origins have also been reported. To date, ESCs derived from parthenogenetic embryos (PgESCs) have been established in some species, including humans, and the possibility to be alternative sources for autologous cell transplantation in regenerative medicine has been proposed. However, some developmental characteristics, which might be important for therapeutic applications, such as multiple differentiation capacity and transplantability of the ESCs of androgenetic origin (AgESCs) are uncertain. Here, we induced differentiation of mouse AgESCs and observed derivation of neural cells, cardiomyocytes and hepatocytes in vitro. Following differentiated embryoid body (EB) transplantation in various mouse strains including the strain of origin, we found that the EBs could engraft in theoretically MHC-matched strains. Our results indicate that AgESCs possess at least two important characteristics, multiple differentiation properties in vitro and transplantability after differentiation, and suggest that they can also serve as a source of histocompatible tissues for transplantation.

• 日本繁殖生物学会の論文
• 2009-06-01

著者

• Matsumoto Kazuya

  Department of Reproductive and Developmental Biology, The Institute of Medical Science, The Universi

• Matsumoto Kazuya

  Department Of Genetic Engineering Graduate School Of Biology Oriented Science And Technology Kinki U

• MITANI Tasuku

  Institute of Advanced Technology, Kinki University

• KATO Hiromi

  Institute of Advanced Technology, Kinki University

• ANZAI Masayuki

  Institute of Advanced Technology, Kinki University

• MURAKAMI Hideki

  Department of Geology, Faculty of Science, Kochi University

• Fukuda Kanji

  Institute Of Advanced Clinical Medicine Kinki University School Of Medicine

• Saeki K

  Department Of Genetic Engineering Graduate School Of Biology Oriented Science And Technology Kinki U

• Murakami Hideki

  Department Of Electrical Engineering Graduate School Of Advanced Sciences Of Matter Hiroshima Univer

• KATO Hiromi

  Department of Pediatrics, Saiseikai Yokohamashi Nanbu Hospital

• Saeki Kazuhiro

  Department of Biological Sciences, Faculty of Science, Nara Women's University

• HOSOI Yoshihiko

  Department of Genetic Engineering, Kinki University

• SAGAWA NORIMASA

  Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine

• Hosoi Y

  Department Of Genetic Engineering Graduate School Of Biology Oriented Science And Technology Kinki U

• TERAMURA Takeshi

  Department of Obstetrics and Gynecology, Graduate School of Medicine, Mie University

• ONODERA Yuta

  Institute of Advanced Clinical Medicine, Kinki University School of Medicine

• ITO Syunsuke

  Department of Genetic Engineering, Graduate School of Biology Oriented Science and Technology, Kinki

• MIHARA Toshihiro

  Department of Genetic Engineering, Graduate School of Biology Oriented Science and Technology, Kinki

• TAKEHARA Toshiyuki

  Department of Genetic Engineering, Graduate School of Biology Oriented Science and Technology, Kinki

• MITANI Tasuku

  Department of Genetic Engineering, Graduate School of Biology Oriented Science and Technology, Kinki

• ANZAI Masayuki

  Department of Genetic Engineering, Graduate School of Biology Oriented Science and Technology, Kinki

• Hosoi Yoshihiko

  Department Of Genetic Engineering Graduate School Of Biology Oriented Science And Technology Kinki U

• Kato Hiromi

  Department Of Genetic Engineering Graduate School Of Biology Oriented Science And Technology Kinki U

• Ito Syunsuke

  Department Of Genetic Engineering Graduate School Of Biology Oriented Science And Technology Kinki U

• Onodera Yuta

  Institute Of Advanced Clinical Medicine Kinki University School Of Medicine

• Mitani Tasuku

  Department Of Genetic Engineering Graduate School Of Biology Oriented Science And Technology Kinki U

• Anzai Masayuki

  Department Of Genetic Engineering Graduate School Of Biology Oriented Science And Technology Kinki U

• Sagawa Norimasa

  Department Of Obstetrics And Gynecology Graduate School Of Medicine Mie University

• Sagawa Norimasa

  Department Of Gynaecology And Obstetrics Kyoto University Graduate School Of Medicine

• Matsumoto Kazuya

  徳島大学医学部

• Teramura Takeshi

  Department Of Obstetrics And Gynecology Graduate School Of Medicine Mie University

• Matsuoka Toshiki

  Department Of Genetic Engineering Graduate School Of Biology Oriented Science And Technology Kinki U

• Takehara Toshiyuki

  Department Of Genetic Engineering Graduate School Of Biology Oriented Science And Technology Kinki U

• Kato Hiromi

  Department Of Bioscience Fukui Prefectural University

• Matsumoto Kazuya

  Department Of Applied Chemistry Kanagawa Institute Of Technology

• Hattori Yoshihisa

  Department Of Obstetrics And Gynecology Keio University School Of Medicine

• HOSOI Yoshihiko

  Department of Biology-Oriented Science and Technology, Division of Genetic Engineering, Kinki University

• TERAMURA Takeshi

  Department of Biology-Oriented Science and Technology, Division of Genetic Engineering, Kinki University

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