Outcome of Long-Term Vagus Nerve Stimulation for Intractable Epilepsy
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概要
- 論文の詳細を見る
The outcome of long-term vagus nerve stimulation (VNS) was evaluated in 13 Japanese patients with intractable epilepsy, all followed up for more than 4 years (48-91 months, median 56 months). VNS achieved a long-lasting and cumulative seizure-control effect in nine of 13 patients. The mean reduction of seizure frequency in the 1st to 4th year was 28%, 47%, 54%, and 63%, respectively. The percentage of patients with >60% seizure reduction in the 1st to 4th year was 15%, 46%, 54%, and 69%, respectively. One patient did not respond to the treatment at all. No patient became completely free from seizure or free from medication, but the number and/or dosage of antiepileptic drugs was reduced in five patients. Ten patients underwent exchange of the generator and continued treatment, and two patients underwent removal of the generator because of the unsatisfactory result. VNS controlled more disabling seizures earlier and more efficiently than less disabling seizures in seven patients. The cumulative reduction of seizures was partly associated with changes in the device setting toward increased stimulation. These effects were similar in patients with or without previous resective surgery. Long-term VNS therapy achieved a favorable outcome in a significant proportion of patients with intractable epilepsy.
- 日本脳神経外科学会の論文
- 2002-11-15
著者
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KAWAI Kensuke
Department of Neurosurgery, Tokyo Metropolitan Neurological Hospital
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Kawai K
Department Of Neurosurgery Tokyo Metropolitan Neurological Hospital
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Kawai Kensuke
Department Of Neuropsychiatry Okayama University Medical School
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Murakami Hideki
Department Of Electrical Engineering Graduate School Of Advanced Sciences Of Matter Hiroshima Univer
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Shimizu H
Epilepsy Research Project Tokyo Metropolitan Organization For Medical Research
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Maehara Taketoshi
Neurosurgery Department Of Brain Medical Science Tokyo Medical And Dental University
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Maehara Taketoshi
Department Of Neurosurgery Tokyo Medical And Dental University
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Shimisu Hiroyuki
Department Of Neurosurgery Tokyo Metropolitan Neurological Hospital
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Shimizu Hiroyuki
Department Of Epidemiology And Preventive Medicine Gifu University School Of Medicine
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Murakami Hideki
Department Of Neurosurgery Tokyo Metropolitan Neurological Hospital
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Shimizu Hiroyuki
Department Of Biochemistry And Molecular Biology Center For Advanced Medical Technology Nippon Medic
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Shimizu Hiroyuki
Department Of Neurosugery Tokyo Metropolitan Neurological Hospital
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