INVOLVEMENT OF PLASMINOGEN ACTIVATOR ACTIVITY IN THE PROCESS OF OVULATION

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概要

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• 卵巣内の線溶系酵素と排卵との関連が注目されているが, 今回排卵過程時に卵胞破裂機序におけるtissue-plasminogen activator (t-PA)活性の意義について検討を加えた. 家兎をhCG (100 IU)静注にて排卵誘発し, 排卵過程における成熟卵胞内のt-PA活性の変動を検討した. 測定法としては, 卵胞の2M KSCN-HC1抽出液にstimulatorとしての可溶性フィブリンを加え, 活性化されたt-PAが添加plasminogenをplasminに変換する際に合成基質から遊離される発色基質を吸光度(405nm)で測定した. 卵胞内t-PA活性は未刺激卵巣では1.54±0.08IU/g tissueであったが, hCG投与1hr後より増加し, 4hrで31.9±5.6IU/gの頂値に達し, その後低下した. 8hrで再び増加(27.5±5.8IU/g)し, 10時間で前値に復した. このように成熟卵胞内のt-PA活性は, 排卵過程で二峰性の変動を示した. in vitro の家兎卵巣灌流系においてhCG (50 IU)を投与し, 排卵に至るまでの卵胞内t-PA活性を測定した. また排卵過程における成熟卵胞および未熟卵胞のt-PA活性を比較検討した. in vitroの系においても80%前後のovulatory efficiencyを有する成熟卵胞内のt-PA活性は, hCG投与4hr後に28.4±4.2IU/gの頂値に達し, その後漸減した. ovulatory efficiency 20%以下である未熟卵胞のt-PA活性は, hCG 投与にもかかわらず12.4±1.9IU/gであり, 成熟卵胞との間に有意差(p<0.01)が認められた. 排卵過程における成熟卵胞内のt-PA活性は, 二峰性の変動を示し, 未熟卵胞においては明確なt-PA 活性の変化が認められなかった. 成熟卵胞におけるt-PA活性の変化は, 卵胞破裂機構に重要な役割を果たしていることが示唆された.

• 社団法人日本産科婦人科学会の論文
• 1990-06-01

著者

• Yoshimura Yasunori

  Department of Obstetrics and Gynecology, School of Medicine, Keio University

• Shiraki Makoto

  Department Of Internal Medicine Gifu University School Of Medicine

• Shiraki Makoto

  Department Of Obstetrics And Gynecology Fujita-gakuen Health University School Of Medicine

• Nakamura Yukio

  Department Of Cardiology Kanazawa Medical Center

• MARUYAMA Kuniyuki

  Department of Obstetrics and Gynecology, Fujita-Gakuen Health University School of Medicine

• KAWAKAMI Seiji

  Department of Obstetrics and Gynecology, Fujita-Gakuen Health University School of Medicine

• KAMIYA Takayuki

  Department of Obstetrics and Gynecology Fujita-Gakuen Health University School of Medicine

• TOMOMATSU Morihiko

  Department of Obstetrics and Gynecology Fujita-Gakuen Health University School of Medicine

• FUKUSHIMA Minoru

  Department of Obstetrics and Gynecology Fujita-Gakuen Health University School of Medicine

• Nakamura Yukio

  Department Of Biotechnology Faculty Of Agriculture Gifu University

• Yoshimura Yasunori

  Department Of Obstetrics And Gynecology Fujita-gakuen Health University School Of Medicine

• Kawakami Seiji

  Department Of Obstetrics And Gynecology Fujita-gakuen Health University School Of Medicine

• Kawakami Seiji

  Department Of Gynecology And Obstetrics Fujita Health University School Of Medicine

• Maruyama Kuniyuki

  Department Of Obstetrics And Gynecology Fujita-gakuen Health University School Of Medicine

• Nakamura Yukio

  Department Of Obstetrics And Gynecology Kyorin University School Of Medicine

• Shiraki Makoto

  Department Of Internal Medicine Gifu University Graduate School Of Medicine

• YOSHIMURA YASUNORI

  Department of Obsterics and Gynaecology, School of Medicine, Keio University

• Yoshimura Yasunori

  Department of Gynecology, School of Medicine, Keio University

• NAKAMURA Yukio

  Department of Agricultural Chemistry, Faculty of Agriculture, Gifu University

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