Non-proteolytic Activation of Human Prorenin by Anti-prorenin Prosegment (pf#1 : 1P-15P) Antiserum

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概要

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• Recombinant human prorenin was activated by incubation with anti-prorenin prosegment (L^<1P>PTDTTTFKRIFLKR^<15P>) antiserum at 4℃. This activation was dependent on the concentration of the antiserum and incubation time. After the activation no molecular weight alteration of prorenin was observed by immunoblotting analysis. A peptide of L^<1P>PTDTTTF^<8P> as well as L^<1P>PTDTTTFKRIFLKR^<15P> potently interfered with the activation. Most of the activated prorenin bound to Protein A Sepharose CL 4B. The K_m and V_<max> values of the activated prorenin were 0.2μM and 23.7μg Ang I/ml/h, respectively, which were similar in level to those of mature renin obtained by trypsinization.

• 社団法人日本農芸化学会の論文
• 1999-03-23

著者

• Nakamura Yoshimasa

  Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University

• Nakamura Yukio

  Department Of Cardiology Kanazawa Medical Center

• Suzuki F

  Laboratory Of Animal Biochemistry Faculty Of Applied Biological Science Gifu University

• Suzuki F

  Gifu Univ Gifu Jpn

• Suzuki Fumiaki

  Department Of Biotechnology Faculty Of Agriculture Gifu University

• Nasir Uddin

  United Graduate School Of Agricultural Science Gifu University

• Nakamura Yukio

  Department Of Biotechnology Faculty Of Agriculture Gifu University

• Nakagawa Tsutomu

  Department of Cardiology, Toyonaka Municipal Hospital

• SUZUKI Fumiaki

  Molecular Genetics Research Center Gifu University

• HATANO Yasuhiko

  Tokiwa Chemical Co.

• TERAZAWA Kazuhiro

  Department of Biotechnology Gifu University

• GOTOH Akiko

  Department of Biotechnology Gifu University

• ISHIDA Yuichi

  Tokiwa Chemical Co.

• Nakagawa Tsuyoshi

  Dep. Of Molecular And Functional Genomics Center For Integrated Res. In Sci. Shimane Univ.

• Suzuki Fumiaki

  United Graduate School Of Agricultural Science Gifu University

• Nakagawa Tsutomu

  Department Of Cardiology Toyonaka Municipal Hospital

• NAKAMURA Yukio

  Department of Agricultural Chemistry, Faculty of Agriculture, Gifu University

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