DIRECT INHIBITORY OVARIAN EFFECTS OF PROLACTIN IN THE PROCESS OF OVULATION

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概要

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• Prolactin (PRL) の卵成熟と卵胞破裂機序に及ぽす直接作用をin vitroでの家兎卵巣灌流装置を用い検討した。成熟日本白色家兎を用い, (1) 一側卵巣を灌流液のみ (対照群), 対側卵巣をporcine PRL 10^2, 10^3 ng/ml (実験群) で灌流し, in vitroにおける排卵, 卵成熟, steroid生合成に及ぼす影響について検討した。(2) 一側卵巣を各種濃度のPRL (10^3, 10^2, 10 ng/ml), 他側卵巣をmedium 199のみにて灌流, 30分後に両側卵巣にhCG (50 IU) を投与し, hCGによってin vitroで惹起される排卵に及ぼすPRLの直接作用について検討した。(1) PRL単独投与は, in vitroで排卵を惹起せず, 灌流12時間後の卵胞卵の80%以上はgerminal vesicle期であり, PRLは卵成熟効果を有していなかった。PRL群におけるprogesterone (P_4) 生合成量は6.1±0.6 ng/mlであり, 対照群との間に有意差は認められなかった。(2) PRL (10^3 ng/ml) はhCGによってin vitroで惹起される排卵を有意に抑制した (ovulatory emciency: PRL 25.8%, 対照群76.2%)。PRL濃度と排卵抑制効果との間には用量反応性が認められた。しかしhCGによって惹起される排卵卵子, 卵胞卵の成熟度に影響を与えなかった。PRL添加群のP_4生合成量85.2±11.7 ng/mlと, 対照群111.8±25.7 ng/mlとの間に有意差は認められなかった。しかしPRL (10^3 ng/ml) は卵巣におけるestradiol生合成を有意に抑制した。PRLは卵核の成熟になんら影響を与えないが, 排卵, とくに卵胞破裂機構に抑制的に作用する。しかしPRLの直接作用は, P_4産生を介していないことを確認した。

• 社団法人日本産科婦人科学会の論文
• 1989-01-01

著者

• 吉村 泰典

  Department of Obstetrics and Gynecology,Keio University School of Medicine

• Nakamura Yukio

  Department Of Cardiology Kanazawa Medical Center

• MARUYAMA Kuniyuki

  Department of Obstetrics and Gynecology, Fujita-Gakuen Health University School of Medicine

• ODA Takahisa

  Department of Obstetrics and Gynecology, Tokyo Dental College

• KAWAKAMI Seiji

  Department of Obstetrics and Gynecology, Fujita-Gakuen Health University School of Medicine

• FUKUSHIMA Minoru

  Department of Obstetrics and Gynecology Fujita-Gakuen Health University School of Medicine

• Nakamura Yukio

  Department Of Biotechnology Faculty Of Agriculture Gifu University

• EBIHARA Teruo

  Department of Obstetrics and Gynecology, Kawasaki Municipal Hospital

• Sawada Tomio

  Department Of Obstetrics And Gynecology Fujita-gakuen Health University School Of Medicine

• TADA Shin

  Departments of Obstetrics and Gynecology Fujita Health University

• HIROTA Yutaka

  Department of Gynecology and Obstetrics, Fujita Health University, School of Medicine

• Tada Shin

  Department Of Obstetrics And Gynecology Fujita Health University

• Tada Shin

  Department Of Obstetrics And Gynecology Fujita-gakuen Health University School Of Medicine

• Oda Takahisa

  Department Of Obstetrics And Gynecology Tokyo Dental College

• Oda Takahisa

  Department Of Obstetrics And Gynecology Tokyo Dental College Ichikawa Hospital

• Hirota Yutaka

  Department Of Obstetrics And Gynecology Fujita-gakuen Health University School Of Medicine

• Hirota Yutaka

  Department Of Gynecology And Obstetrics Fujita Health University School Of Medicine

• Ebihara Teruo

  Department Of Obstetrics And Gynecology Fujita-gakuen Health University School Of Medicine

• Kawakami Seiji

  Department Of Gynecology And Obstetrics Fujita Health University School Of Medicine

• 吉村 泰典

  Department Of Obstetrics And Gynecology School Of Medicine Keio University

• ICHIKAWA Fumitaka

  Department of Obstetrics and Gynecology, Fujita-Gakuen Health University School of Medicine

• Ichikawa Fumitaka

  Department Of Obstetrics And Gynecology Fujita-gakuen Health University School Of Medicine

• Maruyama Kuniyuki

  Department Of Obstetrics And Gynecology Fujita-gakuen Health University School Of Medicine

• Nakamura Yukio

  Department Of Obstetrics And Gynecology Kyorin University School Of Medicine

• ODA TAKAHISA

  Department of Obstetrics and Gynaecology, School of Medicine, Keio University

• SAWADA TOMIO

  Department of Obsterics and Gynaecology, School of Medicine, Keio University

• NAKAMURA Yukio

  Department of Agricultural Chemistry, Faculty of Agriculture, Gifu University

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