Brain Biogenic Amine Contents and Monoamine oxidase Activity in Methylazoxymethanol-induced Microencephalic Rats

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概要

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• The contents of noradrenaline, dopamineand serotonin per g wet weight of reduced cerebra of methylazoxymethanol-induced microencephalic rats were higher than those of control rats on all postpartum days, but the total amounts of these amines per cerebrum did not differ between microencephalic and control rats, except for total amounts of noradrenaline on day 21, and dopamine on days 10 and 21. There was no difference in monoamine oxidase activity per g wet weight of cerebral regions between microencephalic and control rats on days 0 and 21, although the enzyme activity per g wet weight of cerebral regions of 90 days old microencephalic rats was 10-20% higher than that of control rats. Total monoamine oxidase activity per cerebrum of microencephalic rats was lower than that of control rats at all ages. In the remaining portion of the brain, midbrain-colliculus and cerebellum which were not affected morphologically by methylazoxymethanol, there was little difference in biogenic amiiie content and monoamine oxidase activity per g wet weight of tissue between microencephalic and control rats.

• 社団法人 日本農芸化学会の論文

著者

• Nakamura Yukio

  Department Of Biotechnology Faculty Of Agriculture Gifu University

• NAGATA Yukio

  Department of Agricultural Chemistry, Faculty of Agriculture

• SUZUKI Fumiaki

  Department of Agricultural Chemistry, Faculty of Agriculture, Gifu University

• TANDA Juji

  Department of Agricultural Chemistry, Faculty of Agriculture, Gifu University

• IMAI Ritsuko

  Department of Agricultural Chemistry, Faculty of Agriculture, Gifu University

• NAGATA Yukio

  Department of Agricultural Chemistry, Faculty of Agriculture, Gifu University

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