Effects of Substitution of Val for Leu^<11> of Oive Angiotensinogen on Renin Activity

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概要

• 論文の詳細を見る

• A mutant angiotensinogen, L11V, in which Val^<11> was substituted for Leu^<11> of ovine angiotensinogen was prepared to have the same scissile peptide bond as the human one. The mutation did't vary K_m and k_<cat> of human renin for the ovine substrate, but decreased those of rat renin to one half and one fortieth, respectively. Distances between the P1'subsite of angiotensinogens and the 224th (human renin numbering) residue in the S1'subsite of renins were estimated by molecular modelings. The marked decrease in k_<cat> of rat renin for L11V could be attributed to the elongated distance between Val^<11> of L11V and Val^<221> of rat renin. It was also suggested that the distance in the reason why the human substrate cannot be cleaved by heterologous renins.

• 社団法人日本農芸化学会の論文
• 1998-11-23

著者

• Nakamura Yoshimasa

  Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University

• Nakamura Yukio

  Department Of Cardiology Kanazawa Medical Center

• Ebihara Akio

  Institute Of Applied Biochemistry University Of Tsukuba

• Ishida Yasuo

  Agricultural Research Laboratories Agro Division Takeda Chemical Industries Ltd.

• Suzuki F

  Laboratory Of Animal Biochemistry Faculty Of Applied Biological Science Gifu University

• Suzuki F

  Gifu Univ Gifu Jpn

• Suzuki Fumiaki

  Department Of Biotechnology Faculty Of Agriculture Gifu University

• Ishida Yoshihiro

  Laboratory Of Biochemistry Department Of Biofunctional Chemistry Faculty Of Agriculture Kobe Univers

• Nakamura Yukio

  Department Of Biotechnology Faculty Of Agriculture Gifu University

• Nakagawa Tsutomu

  Department of Cardiology, Toyonaka Municipal Hospital

• SUZUKI Fumiaki

  Molecular Genetics Research Center Gifu University

• Orihashi Takenori

  Department Of Biotechnology Faculty Of Agriculture Gifu University

• Nakagawa Tsuyoshi

  Dep. Of Molecular And Functional Genomics Center For Integrated Res. In Sci. Shimane Univ.

• Suzuki Fumiaki

  United Graduate School Of Agricultural Science Gifu University

• INUI Yoshito

  United Graduate School of Agricultural Science, Gifu University

• OKADA Emiko

  Department of Biotechnology, Faculty of Agriculture, Gifu University

• Okada Emiko

  Department Of Biotechnology Faculty Of Agriculture Gifu University

• Nakagawa Tsutomu

  Department Of Cardiology Toyonaka Municipal Hospital

• NAKAMURA Yukio

  Department of Agricultural Chemistry, Faculty of Agriculture, Gifu University

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