Inhibition of Pancreatic Carcinogenesis by Shark Cartilage Proteoglycan in Hamsters
スポンサーリンク
概要
- 論文の詳細を見る
Effects of shark cartilage proteoglycan (SCPG), which has heat-stable inhibitory activities against matrix metalloproteinase (MMP)-2 and -9 in vitro, on pancreatic carcinogenesis were studied in a rapid production model for pancreatic duct adenocarcinomas (PCs) in hamsters. Female Syrian golden hamsters received a diet containing 0% (group 1), 0.2% (group 2) or 0.4% (group 3) of SCPG for 50 days after initiation with N-nitrosobis(2-oxopropyl)amine followed by augmentation pressure. The number of PCs were 3.1 ± 2.0 in group 1 and 1.4 ± 0.9 in group 3, and total ductal lesions including hyperplasia, atypical hyperplasia and PCs were 9.7 ± 4.0 and 5.6 ± 2.7, respectively, the differences being significantly different (P < 0.05). These results were confirmed in a repeat experiment (P < 0.01). Gelatin zymography revealed that oral administration of SCPG did not affect the expression and activation of MMP-2 and MMP-9 in either serum or PC tissue. These results suggest that inhibition of pancreatic carcinogenesis by SCPG might involve a mechanism different from other synthetic-MMPs inhibitors.
- 日本毒性病理学会の論文
- 2006-12-25
著者
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TSUJIUCHI Toshifumi
Laboratory of Cancer Biology and Bioinformatics, Department of Life Science, Faculty of Science and
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Sato Kenji
Department of Anatomy and Physiological Science, Graduate School of Health Care Sciences, Tokyo Medi
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Nakamura Yasushi
Department of Clinical Laboratory Medicine, Wakayama Medical University
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Sato Kenji
Department Of Food Sciences And Nutritional Health Kyoto Prefectural University
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Sakamoto Akika
Division of Pathology, Bozo Research Center Inc.
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Mitsui Masayuki
Mitsui Consulting
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Tsutsumi Masahiro
RI Center, Nara Medical University
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Sato Katsuaki
Central Research Laboratories Of Ajinomoto Co. Inc.
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Nakamura Yoshimasa
Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University
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MORI TOSHIO
Radioisotope Center, Nara Medical University
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Ohtsuki K
Kitasato Univ. Sagamihara Jpn
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Kubota Satoshi
Division Of Human Health And Medical Science Graduate School Of Kuroshio Science Kochi University
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OHTSUKI kozo
Department of Food Science and Nutrition, Kyoto Prefectural University
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OKA Yasuo
Department of Materials Physics, Faculty of Engineering Science, Osaka University
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KITAHASHI Tsukasa
Department of Food Sciences & Nutritional Health, Kyoto Prefectural University
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SAKAMOTO Akika
Department of Food Sciences & Nutritional Health, Kyoto Prefectural University
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MITSUI Masayuki
Radioisotope Research Center, Nara Medical University
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TSUTSUMI Masahiro
Radioisotope Research Center, Nara Medical University
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Tsutsumi Masahiro
Ri Center Nara Medical University
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Tsujiuchi Toshifumi
Laboratory Of Cancer Biology And Bioinfomatics Department Of Life Science Faculty Of Science And Tec
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Sato K
Department Of Food Sciences And Nutritional Health Kyoto Prefectural University
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Nakamura Yasushi
Department Of Clinical Laboratory Medicine Wakayama Medical University
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Kubota S
Division Of Human Health And Medical Science Graduate School Of Kuroshio Science Kochi University
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Oka Yasuo
Department Of Surgery Division Of Gastroenterology Kawasaki Medical University
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Oka Yasuo
Department Of Digestive Surgery Kawasaki Medical School
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Ohtsuki Kozo
Department Of Food Sciences And Nutritional Health Kyoto Prefectural University
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Ohtsuki Kozo
Department Of Food Science And Nutrition Kyoto Prefectural University
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Mori T
Ri Center Nara Medical University
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Kitahashi Tsukasa
Ri Center Nara Medical University
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Mitsui Masayuki
Department Of Molecular Pathology Nara Medical University
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Nakamura Yasushi
Department Of Agricultural Chemistry Faculty Of Agriculture Niigata University
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Sato Kenji
Department Of Anatomy And Physiological Science Graduate School Of Health Care Sciences Tokyo Medica
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