PROGESTERONE PROTECTS OOCYTES FROM PREMATURE DEGENERATION WITHIN THE FOLLICLE

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概要

• 論文の詳細を見る

• 19-noteststerrone 誘導体である gesterinone (R2323) の卵成熟および卵胞破裂機序に及ぼす直接作用について in vitroでの家兎卵巣灌流装置を用いて検討した. 日本白色家兎を用い, (1)一側卵巣をmedium 199のみ(対象群), 対側卵巣をR2323 10^4, 10^3, 10^2ng/ml (R群)で灌流, 30分後に両側卵巣にhCGを投与し, hCGによってin vitroで惹起される排卵に及ぼすR2323の直接作用を検討した. (2)一側卵巣をR2323 10^3, 10^4ng/ml, 対側卵巣をR2323+progesterone (P:10^3ng/ml)で灌流し, 排卵卵子の成熟度, 変性に及ぼすPの効果について検討を加えた. 結果: (1)R2323はhCGによってin vitroで惹起される排卵, 卵成熟に影響を与えなかった(ovulatory efficiency; 対照群71.6±5.6, R群52.7±5.2: %GVBD; 対照92.0%, R群93.3%)群におけるP, estradiol 生合成料量は, 各々218.0±21.1, 1.06±0.15ng/mlであり, 対照群との間に有意差は認められなかった. しかしR(10^4ng/ml)群の排卵卵子の変性率は68.8であり, 有意(p<0.001)に卵変性を惹起した. しかもR2323と変性率の間には用量反応性が認められた. (2)R2323により誘起された卵変性は, P 1μg/mlの補充により, ほぼ完全に回復した(%degeneration; R群70.6%, R+P群21.1%). R2323は, 卵成熟および卵胞破裂機構に影響を与えないが, その抗P作用により卵変性を惹起する. 換言すれば排卵過程におけるPは, 卵胞内におけるpremature degnerationを防御する意味で極めて重要な要因であることが示唆された.

• 社団法人日本産科婦人科学会の論文
• 1990-09-01

著者

• Shiraki Makoto

  Department Of Internal Medicine Gifu University School Of Medicine

• Shiraki Makoto

  Department Of Obstetrics And Gynecology Fujita-gakuen Health University School Of Medicine

• Nakamura Yukio

  Department Of Cardiology Kanazawa Medical Center

• YOSHIDA Yasunori

  Department of Obstetrics and Gynecology, Fujita-Gakuen Health University School of Medicine

• MARUYAMA Kuniyuki

  Department of Obstetrics and Gynecology, Fujita-Gakuen Health University School of Medicine

• ODA Takahisa

  Department of Obstetrics and Gynecology, Tokyo Dental College

• KAWAKAMI Seiji

  Department of Obstetrics and Gynecology, Fujita-Gakuen Health University School of Medicine

• Nakamura Yukio

  Department Of Biotechnology Faculty Of Agriculture Gifu University

• Yoshimura Yasunori

  Department Of Obstetrics And Gynecology Fujita-gakuen Health University School Of Medicine

• Oda Takahisa

  Department Of Obstetrics And Gynecology Tokyo Dental College

• Kawakami Seiji

  Department Of Obstetrics And Gynecology Fujita-gakuen Health University School Of Medicine

• Kawakami Seiji

  Department Of Gynecology And Obstetrics Fujita Health University School Of Medicine

• Maruyama Kuniyuki

  Department Of Obstetrics And Gynecology Fujita-gakuen Health University School Of Medicine

• Nakamura Yukio

  Department Of Obstetrics And Gynecology Kyorin University School Of Medicine

• Shiraki Makoto

  Department Of Internal Medicine Gifu University Graduate School Of Medicine

• ODA TAKAHISA

  Department of Obstetrics and Gynaecology, School of Medicine, Keio University

• NAKAMURA Yukio

  Department of Agricultural Chemistry, Faculty of Agriculture, Gifu University

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