Stepped assessment of gastric emptying of a solid meal using the ^<13>C-octanoic acid breath test
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概要
- 論文の詳細を見る
The ^<13>C-octanoic acid breath test is widely used for evaluating gastric emptying of solids. Since the results of this test are influenced by multiple factors such as the time required to grind the solid meal into smaller particles, the gastroduodenal transport time of the ground meal, and the time required for bowel drug absorption and drug dispersion, the administration of a test meal by the oral route alone cannot result in an accurate measurement of the complicated process of emptying the stomach of solids. The aim of the present study was to evaluate each phase of gastric emptying of solids by varying the administration route of the test meal. Six healthy male volunteers (mean age: 33.2yr) participated in the study. The test meal consisted of a bowl of rice topped with a mixture of boiled chicken and eggs admixed with 100mg of ^<13>C-octanoic acid (total: 273kcal). All subjects were given the test meal by each of the following three methods: 1. Normal oral intake of the test meal, 2. Feeding of the ground test meal through a nasogastric tube, 3. Feeding of the ground test meal through a duodenal tube. For each set of examinations, the mean residence time (MRT), half-emptying time (T_<1/2>), gastric emptying coefficient (GEC), lag phase (L-breath), and measured maximum ^<13>C excretion time (Tmax-measured) were calculated. The data was analyzed to determine the time for each phase of gastric emptying as follows: mean grinding time (MGT)=MRT_<oral>-MRT_<nasogastric>, mean gastroduodenal transport time (MGDTT)=MRT_<nasogastric>-MRT_<nasoduodenal>. Data was expressed as the mean ±SE. The values of the parameters of MGT were 0.82±0.50hr (MRT), 0.64±0.18hr (T_<1/2>, 0.51±0.24hr (L-breath), -0.45±0.30hr (GEC), and 49.2±8.0min (Tmax-measured). The values of the parameters of MGDTT were 0.87±0.38hr (MRT), 0.26±0.29hr (T_<1/2>), 0.92±0.36hr (L-breath), 0.55±0.23hr (GEC), and 63.33±8.16min (Tmax-measured). The times required for the drug absorption and disposition were 1.60±0.20hr (MRT), 1.03±0.24hr (T_<1/2>), 0.10±0.08hr (L-breath), 3.72±0.46hr (GEC), and 19.67±2.11min (Tmax-measured). By varying the administration route of a test meal containing ^<13>C-octanoic acid, we may be able to assess each phase of the emptying of gastric solids in detail, thus leading to a better understanding of gastroduodenal motility.
- 日本平滑筋学会の論文
著者
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Chayama Kazuaki
Department of Medicine and Molecular Biology, Hiroshima University School of Medicine
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TANAKA Shinji
Department of Hepato-Biliary-Pancreatic Surgery, Tokyo Medical and Dental University
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AOKI Shinya
Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo
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Manabe Noriaki
Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School
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Haruma Ken
Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School
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Hodohara Keiko
Department Of Medicine Shiga University Of Medical Science
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Yoshida Shigeto
Division Of Gastroenterology Department Of Division Of Pathology Kawasaki Medical School
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Haruma K
Division Of Gastroenterology Department Of Internal Medicine Kawasaki Medical School
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Haruma Ken
Division Of Gastroenterology Department Of Internal Medicine Kawasaki Medical School
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Aoki Shinya
Division Of Gastroenterology Department Of Internal Medicine Kawasaki Medical School
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Aoki Shinya
Department Of Chemistry And Applied Chemistry Faculty Of Science And Engineering Saga University
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Manabe Noriaki
Division Of Endoscopy And Ultrasound Department Of Clinical Pathology And Laboratory Medicine Kawasa
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Manabe Noriaki
Department Of Clinical Pathology And Laboratory Medicine Kawasaki Medical School
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Yoshida Shigeto
Department Of Medical Zoology Jichi Medical School
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Tanaka S
Department Of Endoscopy Hiroshima University Hospital
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TANAKA TOSHIAKI
Division of Endocrinology and Metabolism, National Center for Child Health and Development
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Chayama K
Department Of Medicine And Molecular Science Graduate School Of Biomedical Sciences Hiroshima Univer
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KAMADA TOMOARI
Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School
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KUSUNOKI HIROAKI
Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School
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Kamada T
Division Of Gastroenterology Department Of Internal Medicine Kawasaki Medical School
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Kamada Tomoari
Division Of Gastroenterology Department Of Internal Medicine Kawasaki Medical School
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Chayama Kazuaki
Deparmtment Of Gastroenterology Toranomon Hospital
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ISHII MANABU
Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School
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SATO MOTONORI
Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School
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SHIOTANI AKIKO
Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School
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Shimoda Tadakazu
Pathology Division National Cancer Center Research Institute And Hospital
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HATA Jiro
Division of Endoscopy and Ultrasound, Department of Clinical Pathology and Laboratory Medicine
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Haruma Ken
First Department Of Internal Medicine
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Hata Jiro
Division Of Endoscopy And Ultrasound Department Of Clinical Pathology And Laboratory Medicine Kawasa
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Haruma Ken
First Department Of Pathology Hiroshima University School Of Medicine
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Tanaka Shinji
Department Of Endoscopy Hiroshima University Hospital
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Tanaka Shinji
Department Of Medicine And Molecular Science Division Of Frontier Medical Science Programs For Biome
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Koga H
Department Of Medical And Clinical Science Graduate School Of Medical Sciences Kyushu University
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Ishii Manabu
Division Of Gastroenterology Department Of Internal Medicine Kawasaki Medical School
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Kuwai Toshio
Department Of Medicine And Molecular Science Hiroshima University Graduate School Of Biomedical Scie
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Kodama H
Laboratory Of Veterinary Immunology Division Of Veterinary Science Graduate School Of Agriculture An
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Sato Motonori
Division Of Gastroenterology Department Of Internal Medicine Kawasaki Medical School
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Kusunoki Hiroaki
Division Of General Medicine Kawasaki Medical School
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Chayama Kazuaki
Department Of Medicine And Molecular Science Hiroshima University Graduate School Of Biomedical Scie
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Tanaka Toshiaki
Division Of Gastroenterology Department Of Internal Medicine Kawasaki Medical School
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Manabe Noriaki
Division Of Endoscopy And Ultrasonography Department Of Clinical Pathology And Laboratory Medicine K
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Tanaka Shinji
Programs For Biomedical Research Division Of Frontier Medical Science Department Of Medicine And Mol
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Tanaka Toshiaki
Division Of Endocrinology And Metabolism National Center For Child Health And Development
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Yoshida Shigeto
Department Of Endoscopy Hiroshima University Hospital
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HATA Jiro
Division of Endoscopy and Ultrasonography, Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School
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KUSUNOKI Hiroaki
Division of Endoscopy and Ultrasonography, Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School
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