Effects of Aged Garlic Extract (AGE) on Colorectal Adenomas : a double-blinded study

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概要

• 論文の詳細を見る

• Aged garlic extract (AGE) is a material that has the possibility of a cancer-preventive effect according to epidemiologic and animal studies. In order to confirm the effects of AGE on colorectal adenomas, we conducted a double-blinded randomized study using high-AGE (AGE 2.4 ml/day) and low-AGE (AGE 0.16 ml/day) doses 1 groups. Fifty-one patients who were diagnosed as having colorectal adenomas by colonoscopy were randomly assigned to the high-AGE and low-AGE groups. The number and size of adenomas before intake (0 month) and 6 and 12 months after intake were measured using colonoscopy. In 37 patients chosen as efficacy evaluated subjects, 47.4% (9/19) in the high-AGE and 66.7% (12/18) in the low-AGE group had at least one new adenoma for the first and second interval (0 to 12 months after intake), and its relative risk was 0.71. The decrease rate of at least one adenoma was 50.0% (7/14) in the high-AGE group for the second interval (6 to 12 months after intake), whereas there was no decrease in subjects in the low-AGE group (p=0.02). The difference from the base-line for total size of adenomas increased in the low-AGE group, whereas an increase in the high-AGE group was suppressed for the second interval (p=0.04). The difference from the base-line for the total size of adenomas in subjects who had adenomas on the base-line increased in the low-AGE group and decreased in the high-AGE group for the second interval (p=0.03). The results of this study suggest the possibility of preventive and therapeutic effects of AGE on colorectal adenomas, though it is necessary to investigate these in larger-scale and longer-term trials.

• 広島大学の論文

著者

• Chayama Kazuaki

  Department of Medicine and Molecular Biology, Hiroshima University School of Medicine

• TANAKA Shinji

  Department of Hepato-Biliary-Pancreatic Surgery, Tokyo Medical and Dental University

• KITADAI Yasuhiko

  Department of Internal Medicine, Hiroshima University Graduate School of Biomedical Science

• Kitadai Y

  Department Of Medicine And Molecular Science Hiroshima University Graduate School Of Biomedical Scie

• Kitadai Yasuhiko

  広島大学 医歯薬総研究分子病態制御内科学

• Haruma Ken

  Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School

• Kudo Yasusei

  First Department Of Pathology Hiroshima University School Of Medicine

• Haruma K

  Division Of Gastroenterology Department Of Internal Medicine Kawasaki Medical School

• Haruma Ken

  Division Of Gastroenterology Department Of Internal Medicine Kawasaki Medical School

• Kajiyama G

  Onomichi General Hospital

• Manabe Noriaki

  Division Of Endoscopy And Ultrasound Department Of Clinical Pathology And Laboratory Medicine Kawasa

• Manabe Noriaki

  Department Of Clinical Pathology And Laboratory Medicine Kawasaki Medical School

• Tanaka S

  Department Of Endoscopy Hiroshima University Hospital

• Chayama K

  Department Of Medicine And Molecular Science Graduate School Of Biomedical Sciences Hiroshima Univer

• NAGATA Shinji

  Department of Internal Medicine, Hiroshima City Asa Hospital

• YOSHIHARA Masaharu

  Health Service Center, Hiroshima University

• KUNIHIRO Masaki

  Department of Endoscopy, Hiroshima University Hospital

• SUMII Masaharu

  Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Bio

• KAJIYAMA Goro

  Onomichi General Hospital

• Chayama Kazuaki

  Deparmtment Of Gastroenterology Toranomon Hospital

• Kunihiro Masaki

  Department Of Endoscopy Hiroshima University Hospital

• Shimoda Tadakazu

  Pathology Division National Cancer Center Research Institute And Hospital

• Haruma Ken

  First Department Of Internal Medicine

• Kajiyama Goro

  First Department Of Internal Medicine

• Kitadai Yasuhiko

  Department Of Cancer Biology The University Of Texas

• Yoshihara Masaharu

  Health Service Center Hiroshima University

• Haruma Ken

  First Department Of Pathology Hiroshima University School Of Medicine

• Tanaka Shinji

  Department Of Endoscopy Hiroshima University Hospital

• Tanaka Shinji

  Department Of Medicine And Molecular Science Division Of Frontier Medical Science Programs For Biome

• Nagata Shinji

  Department Of Endoscopy Hiroshima University Hospital

• Nagata Shinji

  Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni

• Sumii Masaharu

  Department Of Medicine And Molecular Science Division Of Frontier Medical Science Programs For Biome

• Sumii Masaharu

  Department Of Developmental Biology And Oncology Research Institute For Radiation Biology And Medici

• Chayama Kazuaki

  Department Of Medicine And Molecular Science Hiroshima University Graduate School Of Biomedical Scie

• Tanaka Shinji

  Programs For Biomedical Research Division Of Frontier Medical Science Department Of Medicine And Mol

• NAGATA Shinji

  Department of Agricultural Chemistry, Kochi University

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