Effect of Cetraxate, a Mucosal Protective Agent, on Gastric Mucosal Blood Flow and Gastric Clarithromycin Concentration in Nicotine-treated Rats
スポンサーリンク
概要
- 論文の詳細を見る
Our previous study demonstrated that combination treatment with cetraxate plus omeprazole, amoxicillin, and clarithromycin is effective for the eradication of Helicobacter pylon in smokers. To evaluate the effect of cetraxate on gastric mucosal blood flow (GMBF) and the gastric concentration of clarithromycin in nicotine-treated rats, 10 rats were divided into two groups given nicotine with or without cetraxate, and GMBF was measured by laser Doppler blood flowmetry. Another 36 rats were divided into three groups (control, nicotine, and nicotine + cetraxate). Clarithromycin was administered intraduodenally and nicotine was administered after 30 minutes, with cetraxate being given 30 minutes later. The gastric mucosal clarithromycin concentration was measured. After cetraxate administration, GMBF increased significantly in the nicotine + cetraxate group compared with the nicotine group (p<0.05). The mucosal clarithromycin concentration increased in the nicotine + cetraxate group compared with the nicotine group, but the difference was not significant. Our results indicate that cetraxate increased GMBF in nicotine-treated rats.
- 川崎医科大学の論文
著者
-
ITO Masanori
Department of Neurological Surgery, Juntendo University Urayasu Hospital
-
TANAKA Shinji
Department of Hepato-Biliary-Pancreatic Surgery, Tokyo Medical and Dental University
-
Haruma Ken
Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School
-
Haruma K
Division Of Gastroenterology Department Of Internal Medicine Kawasaki Medical School
-
Haruma Ken
Division Of Gastroenterology Department Of Internal Medicine Kawasaki Medical School
-
HONDA Keisuke
Division of Gastroenterology, Department of Medicine, Kawasaki Medical School
-
Ito Masanori
Department Of Medicine And Molecular Science Hiroshima University Graduate School Of Biomedical Scie
-
Tanaka S
Department Of Endoscopy Hiroshima University Hospital
-
KAMADA TOMOARI
Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School
-
FUJIMURA YOSHINORI
Department of Gastroenterology, Kawasaki Hospital
-
SUGIU Kuniaki
Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School
-
KOGA Hideki
Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School
-
TAKEDA Masaharu
Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School
-
KUSUNOKI HIROAKI
Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School
-
Sumii K
First Department Of Internal Medicine Hiroshima University School Of Medicine
-
Kamada T
Division Of Gastroenterology Department Of Internal Medicine Kawasaki Medical School
-
Kamada Tomoari
Division Of Gastroenterology Department Of Internal Medicine Kawasaki Medical School
-
Haruma Ken
First Department Of Internal Medicine
-
NAGASHIMA YUICHI
Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School
-
FUJIMURA YOSHINORI
Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School
-
Takeda Masaharu
Division Of Gastroenterology Department Of Medicine Kawasaki Medical School
-
Fujimura Yoshinori
Department Of Gastroenterology Kawasaki Hospital
-
Fujimura Yoshinori
Division Of Gastroenterology Department Of Medicine Kawasaki Medical School
-
Tanaka Shinji
Department Of Endoscopy Hiroshima University Hospital
-
Mei Qian
Division Of Gastroenterology Department Of Internal Medicine Kawasaki Medical School
-
Koga H
Department Of Medical And Clinical Science Graduate School Of Medical Sciences Kyushu University
-
Kuwai Toshio
Department Of Medicine And Molecular Science Hiroshima University Graduate School Of Biomedical Scie
-
Honda Keisuke
Division Of Gastroenterology Department Of Medicine Kawasaki Medical School
-
Sugiu Kuniaki
Division Of Gastroenterology Department Of Internal Medicine Kawasaki Medical School
-
Kusunoki Hiroaki
Division Of General Medicine Kawasaki Medical School
-
Nagashima Yuichi
Division Of Gastroenterology Department Of Internal Medicine Kawasaki Medical School
-
Honda Keisuke
Department Of Comprehensive Medicine Kawasaki Medical School
-
Ito Masanori
Department Of Materials Science And Chemistry University Of Hyogo
-
KUSUNOKI Hiroaki
Division of Endoscopy and Ultrasonography, Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School
関連論文
- Pathological Laughter Caused by Frontal Glioblastoma
- Metastatic Skull Base Tumor From Thymic Carcinoma Mimicking Tolosa-Hunt Syndrome : —Case Report—
- Efficacy of the Addition of Prokinetics for Proton Pump Inhibitor (PPI) Resistant Non-erosive Reflux Disease (NERD) Patients: Significance of Frequency Scale for the Symptom of GERD (FSSG) on Decision of Treatment Strategy
- A randomized, double-blind, placebo-controlled clinical study of the histamine H_2-receptor antagonist famotidine in Japanese patients with nonerosive reflux disease
- KNACK AND PRACTICAL TECHNIQUE OF COLONOSCOPIC TREATMENT FOCUSED ON ENDOSCOPIC MUCOSAL RESECTION USING SNARE
- Expression of Aurora B and alternative variant forms in hepatocellular carcinoma and adjacent tissue
- PE-527 Short and Mid Term Outcomes of The Minimum Invasive Renal Artery Intervention (MIRAI) Trial(Kidney/Renal circulation-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- The committee for revision of the Clinical Practice Guidelines for Hepatocellular Carcinoma
- Simultaneous Bilateral Vertebral Artery Occlusion in the Lower Cervical Spine Manifesting as Bow Hunter's Syndrome
- Impact of ω-5 Gliadin on Wheat-Dependent Exercise-Induced Anaphylaxis in Mice
- A duodenal follicular lymphoma associated with the lesion mimicking MALT lymphoma in terminal ileum and Bauhin valve
- Neutron Inelastic Scattering Study on a Single Crystal of Tb_2Ti_2O_7,a Magnetically Frustrated Pyrochlore System
- Giant inflammatory polyp in a crohn's disease patient
- An ileal perforation after infliximab treatment for crohn's disease in a heart transplant patient : A case report
- PE-084 Late Angiographic Stent Thrombosis (LAST) after Cypher Stents Imaplantation(Coronary revascularization, PCI-8 (IHD) PE14,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Assessing the efficacy of famotidine and rebamipide in the treatment of gastric mucosal lesions in patients receiving long-term NSAID therapy (FORCE-famotidine or rebamipide in comparison by endoscopy)
- PYOGENIC GRANULOMA IN THE ILEUM
- A Case of Small Intestinal Ulcers with Severe Hypoproteinemia Induced by Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
- The long-term outcome of patients with bleeding gastric varices after balloon-occluded retrograde transvenous obliteration
- Antibodies to Helicobacter pylori and CagA protein are associated with the response to antibacterial therapy in patients with H. pylori-positive AP12-MALT1-negative gastric MALT lymphoma
- RELATIONSHIP BETWEEN HISTOPATHOLOGICAL FEATURES AND TYPE V PIT PATTERN DETERMINED BY MAGNIFYING VIDEOCOLONOSCOPY IN EARLY COLORECTAL CARCINOMA
- Effects of Aged Garlic Extract (AGE) on Colorectal Adenomas : a double-blinded study
- Mutation of the von Hippel-Lindau (VHL) gene in human colorectal carcinoma : Association with cytoplasmic accumulation of hypoxia-inducible factor (HIF)-1α
- Expression of VEGF-C and VEGF-D at the invasive edge correlates with lymph node metastasis and prognosis of patients with colorectal carcinoma
- ENDOSCOPIC ULTRASONOGRAPHY FOR ASSESSMENT OF MEDICAL TREATMENT IN PATIENTS WITH GASTRIC MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA
- Detailed colonoscopy for detecting early superficial carcinoma : recent developments
- ピオグリタゾンは肥満型糖尿病の腎症を改善させる--腎臓の酸化反応を緩和する
- ECHINOSTOMA HORTENSE ASADA INFECTION IN THE DUODENUM : INCIDENTAL FINDINGS DURING ROUTINE GATROINTESTINAL ENDOSCOPY
- Successful Therapeutic Combination of an Antispasmodic and Progressive Pneumatic Dilation in a Patient with Esophageal Motor Disorder : Importance of Differentiation of Classic and Vigorous Achalasia
- The Transradial Directional Coronary Atherectomy
- The efficacy of transradial coronary artery stenting in the elderly patients (≥80 years) compared to non-elderly patients (
- A CASE OF DIFFUSE-TYPE EARLY GASTRIC CANCER WITH NODULAR GASTRITIS
- Inhabition of IкB kinase βrestrains oncogenic proliferation of pancreatic cancer cells
- THERAPEUTIC STRATEGY FOR COLORECTAL LATERALLY SPREADING TUMOR
- Pathogenetic role of the tyrosine-phosphorylated CagA EPIYA sequence of Helicobacter pylori in histological gastritis in Japanese patients
- Clinical prevention of gastric cancer by Helicobacter pylori eradication therapy : a systematic review
- Colorectal endoscopic submucosal dissection : present status and future perspective, including its differentiation from endoscopic mucosal resection
- Relation between histologic gastritis and gastric motility in Japanese patients with functional dyspepsia : evaluation by transabdominal ultrasonography
- NODULAR GASTRITIS WITH HELICOBACTER PYLORI INFECTION IS STRONGLY ASSOCIATED WITH DIFFUSE-TYPE GASTRIC CANCER IN YOUNG PATIENTS
- TECHNIQUES AND PITFALLS OF ENDOSCOPIC SUBMUCOSAL DISSECTION FOR COLORECTAL TUMORS
- Stepped assessment of gastric emptying of a solid meal using the ^C-octanoic acid breath test
- PIT PATTERN DIAGNOSIS FOR COLORECTAL NEOPLASIA USING NARROW BAND IMAGING MAGNIFICATION
- Depressed-type, early duodenal carcinoma (carcinoma in situ) treated by endoscopic mucosal resection
- ENDOSCOPIC DIAGNOSIS AND TREATMENT OF LOCAL RESIDUAL/RECURRENT LESIONS AFTER ENDOSCOPIC MUCOSAL RESECTION FOR EARLY COLORECTAL CARCINOMA
- Serum pepsinogen concentration as a marker of Helicobacter pylori infection and the histologic grade of gastritis ; evaluation of gastric mucosa by serum pepsinogen levels
- Isolated granulomatous gastritis successfully treated by Helicobacter pylori eradication : a possible association between granulomatous gastritis and Helicobacter pylori
- Short- and Long-Term Outcome of No Re-Flow Phenomenon with IABP Support(Coronary Revascularization, PTCA/Stent/DCA/Rotablator/New Device 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- NODULAR GASTRITIS AND GASTRIC CANCER
- CASE OF EARLY GASTRIC CANCER WITH NODULAR GASTRITIS
- Activation of B-Myb by E2F1 in hepatocellular carcinoma
- DIAGNOSIS OF INVASION DEPTH IN EARLY COLORECTAL CARCINOMA BY PIT PATTERN ANALYSIS WITH MAGNIFYING ENDOSCOPY
- Arteriovenous Fistula Arising From the Persistent Primitive Olfactory Artery With Dual Supply From the Bilateral Anterior Ethmoidal Arteries : Case Report
- Lumbar Congestive Myelopathy Mimicking Neoplasia Without Concurrent Vascular Malformation : Case Report
- Orbital Cavernous Hemangioma Presenting With Atypical Appearance : Case Report
- Pleural Malignant Mesothelioma Causing Cord Infiltration Through the Nerve Root : Case Report
- Basilar Apex Aneurysm Manifesting as Third Ventricular Mass and Obstructive Hydrocephalus
- Orbital Dermoid Cyst With Intratumoral Inflammatory Hemorrhage
- Atypical Cervical Astrocytoma Manifesting as Occipitalgia : Case Report
- Orbital Pseudotumor Associated With Retrobulbar Hematoma : Case Report
- Multiple Meningeal Cysts Affecting the Whole Craniospinal Axis : Case Report
- Spinal Intramedullary Arteriovenous Malformation Draining into the Petrosal and Straight Sinuses resulting in Intraventricular Hemorrhage: A Case Report
- Asymptomatic Huge Congenital Arachnoid Cyst Successfully Treated by Endoscopic Surgery
- Rapid Growth of Congenital Diffuse Brain Tumor Considered to Be Teratoma
- Idiopathic Calvarial Thinning
- Evaluation of clinical prognosis and activities of daily living using functional independence measure in patients with hip fractures
- Simple and non-invasive assessment of the accommodation reflex of the proximal stomach
- Theoretical Study on Metal NMR Chemical Shifts. Electronic Mechanism of the Xe Chemical Shift
- Rebamipide, a gastro-protective and anti-inflammatory drug, promotes gastric ulcer healing following eradication therapy for Helicobacter pylori in a Japanese population : a randomized, double-blind, placebo-controlled trial
- Posterior Sagittal Anorectoplasty for a Recto-vaginal Fistula Occurring 30 Years after Swenson's Operation for Hirschsprung's Disease
- PE-071 Transradial Coronary Intervention for Chronic Total Occlusion Using 6 French Guiding Catheters(Angina Pectoris, Clinical 1 (IHD) : PE13)(Poster Session (English))
- PE-070 Transradial Coronary Intervention for Chronic Total Occlusion(Angina Pectoris, Clinical 1 (IHD) : PE13)(Poster Session (English))
- Duodenal hypersensitivity to acid in patients with functional dyspepsia-pathogenesis and evaluation
- High-salt and high-fat diets promote corpus atrophic gastritis in Mongolian gerbils
- Real-time evaluation of dyspeptic symptoms and gastric motility induced by duodenal acidification using noninvasive transnasal endoscopy
- Effect of Cetraxate, a Mucosal Protective Agent, on Gastric Mucosal Blood Flow and Gastric Clarithromycin Concentration in Nicotine-treated Rats
- Current status and perspective of antiangiogenic therapy for cancer : hepatocellular carcinoma
- A Hepatic Lipoma Mimicking Angiomyolipoma of the Liver : Report of a Case
- Left Sided Portal Hypertension Caused by Serous Cystadenoma of the Pancreas : Report of a Case
- Ecabet sodium induces neuronal nitric oxide synthase-derived nitric oxide synthesis and gastric adaptive relaxation in the human stomach
- NEURONS INNERVATING THE RING GLAND IN LARVAE OF THE BLOW FLY, PROTOPHORMIA TERRAENOVAE(Physiology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- PEPTIDES-IMMUNOCYTOCHEMISTRY OF CEREBRAL NEURONS PROJECTING TO THE RETROCEREBRAL COMPLEX IN THE BLOW FLY PROTOPHORMIA TERRAENOVAE(Physiology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- RELATION BETWEEN OBESITY AND ADENOMATOUS POLYPS OF THE LARGE BOWEL
- Pneumoretroperitoneum, Pneumomediastinum, Pneumopericardium, and Subcutaneous Emphysema Complicating Sigmoidoscopy : Report of a Case
- Intramedullary Primitive Neuroectodermal Tumor Presenting With Rapidly-Progressive Cauda Equina Syndrome : Case Report
- Correlation of the Plasma Cholesterol-lowering Effect of Dietary Glycine with the Alteration of Hepatic Phospholipid Composition in Rats
- Anaplastic Pleomorphic Xanthoastrocytoma With a Component of Anaplastic Astrocytoma Presenting as Skull Base Tumor Followed by Downward Extracranial Extension : Case Report
- Pulse Wave Velocity in Lower-Limb Arteries among Diabetic Patients with Peripheral Arterial Disease
- Micromorphology Memory in Amphiphilic Polypeptides
- Central Pontine and Extrapontine Myelinolysis in an Infant Associated With the Treatment of Craniopharyngioma
- Posterior Fossa Dural Arteriovenous Fistula As a Probable Cause of Congestive Myelopathy
- Atypical Dural Arteriovenous Fistula Associated With Meningitis
- Isolated Angiitis in the Hypothalamus Mimicking Brain Tumor
- Current status of molecularly targeted therapy for hepatocellular carcinoma : basic science
- NMR and NQR Studies on Local Electronic and Magnetic Properties of Various Cuprates : II-C Neutron Scattering, NMR and NQR and Ultrasonics : II Oxide Superconductors; Experiments II : Electronic States
- Angiogenic switch as a molecular target of malignant tumors
- A novel angiogenic switch gene as a molecular target for treatment of hepatocellular carcinoma
- Sacral parasite with histopathological features of an unequally conjoined twin
- Repeat hepatectomy is the most useful treatment for recurrent hepatocellular carcinoma
- Potential role for vascular endothelial growth factor-D as an autocrine factor for human gastric carcinoma cells
- Expression of platelet-derived growth factor (PDGF)-B and PDGF-receptor β is associated with lymphatic metastasis in human gastric carcinoma