Expression of Vascular Endothelial Growth Factor (VEGF) and Specific Receptors (Flt-1 and Flk-1) in Rat Tongue Carcinogenesis Induced by 4-Nitroquinoline 1-Oxide
スポンサーリンク
概要
- 論文の詳細を見る
Tongue carcinoma is one of the most common malignant neoplasms in the oral cavity. To assess the role for angiogenesis in carcinogenesis of tongue carcinoma, we performed qualitative and quantitative analyses of vascular endothelial growth factor (VEGF)and two forms of the specific receptors (VEGFRs), Flt-1 and Flk-1, in rat tongue squamous cell carcinoma induced by 4-nitroquinoline 1-oxide. In situ hybridization and immunohistochemistry revealed the colocalization of VEGF and VEGFRs mRNA signals and protein immunoreactivities, respectively in the cytoplasm of the normal epithelial cells, dysplastic cells, cancer cells, and vascular endothelial cells. Both the labeling indices of VEGF and VEGFRs in immunostained sections and the immunoreactive intensities on immunoblots for VEGF and VEGFRs disclosed a duration-dependent increase along with disease progression. An increase in the VEGF labeling index positively correlated with increases in the Ki-67 labeling index and blood vessel density. The present results suggest that angiogenesis is necessary for carcinogenesis, and that VEGF has relevance to the pathomechanism of tongue carcinoma via paracrine and autocrine mechanisms.
- 日本組織細胞化学会の論文
著者
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SAWADA Tatsuo
Department of Mechanical Engineering, Keio University
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Kobayashi Makio
Department of Pathology, Tokyo Women’s Medical University
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Ogiuchi H
Tokyo Women's Medical Univ.
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Ogiuchi Hideki
東京女子医科大学 医学研究科 歯口外
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Ogiuchi Hideki
Department Of Maxillofacial Surgery Tokyo Women's Medical University School Of Medicine
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Ando T
Department Of Oral And Maxillofacial Surgery Tokyo Women's Medical University School Of Medicin
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Ando Takao
Central Research Division Takeda Chemical Industries Ltd.
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Ando Tomohiro
Department Of Kansei Engineering Shinshu University
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Andoh Takao
Central Research Division Takeda Chemical Industries Ltd.
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Maejima Masayuki
Department of Oral and Maxillofacial Surgery, Tokyo Women's Medical University, Graduate School of M
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Maruoka Yasubumi
Department of Oral and Maxillofacial Surgery, Tokyo Women's Medical University, School of Medicine
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Kawaguchi Motoko
Department Of Surgical Pathology Tokyo Women's Medical University
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Kobayashi M
Department Of Public Health Social Medicine And Medical Informatics Ehime University Graduate School
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Kobayashi Masatoshi
Department Of Anatomy & Histology Kurume University School Of Medicine
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Kobayashi Makio
Department Of Pathology Tokyo Women's Medical College
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Kobayashi Makio
Dept. Of Pathology Tokyo Women's Medical University
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Kobayashi Makio
東京女子医科大学 消化器内科学
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Kobayashi M
Departments Of Pathology Tokyo Women
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Sawada T
Department Of Pathology Tokyo Women's Medical University
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Kobayashi Minatsu
Department Of Public Health Social Medicine And Medical Informatics Ehime University Graduate School
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Kobayashi Minatsu
Epidemiology And Prevention Division Research Center For Cancer Prevention And Screening National Ca
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Sawada Tatsuo
Department Of Mechanical Engineering Keio University
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Kobayashi M
Aska Pharmaceutical Co. Ltd. Research & Development Division
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Kobayashi Makio
Department Of Immunology And Pathology Yamanashi Medical College
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Sawada Tatsuo
Department Of Pathology Tokyo Women's Medical College
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Maejima Masayuki
Department Of Oral And Maxillofacial Surgery Tokyo Women's Medical University Graduate School O
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Maruoka Yasubumi
Department Of Oral And Maxillofacial Surgery Tokyo Women's Medical University School Of Medicin
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Kobayashi Makio
Department of Agricultural Chemistry, Faculty of Agriculture, Hokkaido University
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