Adrenomedullin antagonist suppresses in vivo growth of human pancreatic cancer cells in SCID mice by suppressing angiogenesis
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概要
- 論文の詳細を見る
Since it is reported that adrenomedullin (AM) upregulated by hypoxia inhibits hypoxic cell death, we examined the effects of AM antagonist (AM C-terminal fragment; AM(22-52)) on the growth of pancreatic cancer cells. We for the first time demonstrated that AM antagonist significantly reduced the in vivo growth of the pancreatic cancer cell line. Immunohistochemical analysis demonstrated that the mean diameter of blood vessels was significantly smaller in the tumor tissues treated with AM antagonist than in those treated with AM N-terminal fragment (AM(1-25)) and that the PCNA-labeling index was lower in the former than in the latter. Then we demonstrated that AM antagonist showed no effect on the in vitro growth of the pancreatic cancer cell line. These results showed that AM played an important role in the growth of pancreatic cancer cells in vivo, suggesting that AM antagonist might be a useful tool for treating pancreatic cancers.
- Nature Publishing Groupの論文
- 2003-02-27
著者
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Kondo Takeshi
Stem Cell Transplantation Center Hokkaido University Hospital
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Hosokawa M
Division Of Pathology Cancer Institute Hokkaido University School Of Medicene
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Kobayashi M
Department Of Public Health Social Medicine And Medical Informatics Ehime University Graduate School
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Kondo Takeshi
北海道大学 医学研究科消化器内科学
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Kawamura Takahito
Department Of Internal Medicine Hakodate Municipal Hospital
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Kondo Takeshi
Department Of Medicine Ii Hokkaido University Graduate School Of Medicine
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Kondo Takeshi
Department Of Gastroenterology And Hematology Hokkaido University Graduate School Of Medicine
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Shindoh Masanobu
Division Of Oral Pathobiological Science Graduate School Of Dental Medicine Hokkaido University
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Asaka M
Department Of Gastroenterology Hokkaido University Graduate School Of Medicine
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