Viral-mediated stabilization of AU-rich element containing mRNA contributes to cell transformation
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概要
- 論文の詳細を見る
E4orf6 is one of the oncogene products of adenovirus and it also plays an important role for transportation of cellular and viral mRNA during the late phase of virus infection. We previously revealed that E4orf6 controls the fate of AU-rich element (ARE) containing mRNA by perturbing the CRM1-dependent export mechanism. Here, we show that E4orf6 stabilizes ARE-mRNA through the region required for its oncogenic activity and ubiquitin E3 ligase assembly. Cells that failed to stabilize ARE-mRNA after HuR knockdown were unable to produce colonies in soft-agar, even when E4orf6 was expressed. Furthermore, the stabilized ARE-mRNA induced the transformation of rodent immortalized cells. These findings indicate that stabilized ARE-mRNA is necessary, if not all, for the oncogenic activity of E4orf6 and has the potential to transform cells at least under a certain condition.
- Nature Publishing Groupの論文
- 2011-06-30
著者
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Kitagawa Yoshimasa
Oral Diagnosis And Medicine Department Of Oral Pathobiological Science Graduate School Of Dental Med
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Kitagawa Yoshimasa
北海道大学 歯学研究科口腔病態学口腔診断内科学
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Aoyagi Mariko
Department Of Oral Pathology And Biology Division Of Oral Pathobiological Science Hokkaido Universit
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Higashino Fumihiro
Department Of Oral Pathology And Biology Division Of Oral Pathobiological Science Hokkaido Universit
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Kitamura Tetsuya
Department Of Oral Pathology & Biology Hokkaido University Graduate School Of Dental Medicine
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Higashino Fumihiro
Department Of Oral Pathology & Biology Hokkaido University Graduate School Of Dental Medicine
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Shindoh Masanobu
Division Of Oral Pathobiological Science Graduate School Of Dental Medicine Hokkaido University
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Shindoh Masanobu
Department Of Oral Pathology And Biology Division Of Oral Pathobiological Science Hokkaido Universit
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Totsuka Yasunori
Oral And Maxillofacial Surgery Department Of Oral Pathobiological Science Graduate School Of Dental
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