Evaluation of Adhesion between Material and Epithelium using a Three-dimensional Human Epidermal Model
スポンサーリンク
概要
- 論文の詳細を見る
The use of dental implants currently entails problems associated with lack of adhesion to the oral mucosa at the point of abutment, which differs from that of natural teeth. Usually, the experimental evaluation of adhesion between test implant materials and soft tissue requires animal experiments. In this study, to facilitate easier evaluation, adhesion experiments were performed using a three-dimensional (3D) in vitro epidermal cell culture model. The implant materials examined were nano hydroxyapatite (nHAp) coated polyethylene terephthalate (PET), uncoated PET, zirconia, and titanium. The nHAp particles exhibited high cell adhesion, and nHAp coated PET exhibited high tissue-adhesion in the 3D epidermal cell culture in vitro. Zirconia exhibited substantial tissue adhesion to the 3D epithelial tissue, but titanium exhibited little adhesion. This 3D in vitro epidermal cell culture model could be used instead of animal experiments to facilitate easier evaluation of adhesion between tissue and materials, and it could be useful in screening tests for the development of tissue adhesive materials and processing conditions.
- ナノ・バイオメディカル学会の論文
著者
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Kitagawa Yoshimasa
Oral Diagnosis And Medicine Department Of Oral Pathobiological Science Graduate School Of Dental Med
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Akasaka Tsukasa
Department Of Biomedical Dental Materials And Engineering Graduate School Of Dental Medicine Hokkaid
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Watari Fumio
Department Of Applied Science Faculty Of Engineering
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AKASAKA Tsukasa
Department of Biomedical Materials and Engineering, Department of Oral Health Science, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan.
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FURUHASHI Kazunori
Oral Diagnosis and Medicine, Department of Oral Pathobiological Science,
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KITAGAWA Yoshimasa
Oral Diagnosis and Medicine, Department of Oral Pathobiological Science,
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