Pain may predict poor prognosis in patients with oral squamous cell carcinoma
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概要
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Objectives: We have previously reported that the histologic mode of invasion of oral squamous cell carcinoma (OSCC) is a significant risk factor for pain. We sought to determine whether pain is a risk factor for poor prognosis in patients with OSCC. Study Design: We evaluated the relationships between overall survival rates (OSRs) and clinicopathological variables, including gender, age, T- and N-stages, pathologic findings, and pain in 109 consecutive patients with untreated OSCC. Results: Of these 109 patients, 40 (37%) reported spontaneous pain. Univariate analysis showed that the OSR of patients with spontaneous pain was significantly lower than that of patients without pain (P = 0.002). Multivariate analysis revealed that spontaneous pain and N-stage were significant independent predictors of OSR. Conclusion: This is the first report showing that spontaneous pain before treatment may be associated with poor prognosis in patients with OSCC.
著者
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Kitagawa Yoshimasa
Oral Diagnosis And Medicine Department Of Oral Pathobiological Science Graduate School Of Dental Med
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Kitagawa Yoshimasa
北海道大学 歯学研究科口腔病態学口腔診断内科学
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Notani Ken-ichi
Oral Diagnosis And Oral Medicine Department Of Oral Pathobiological Science Graduate School Of Denta
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Notani Ken-ichi
Oral Diagnosis And Medicine Department Of Oral Pathobiological Science Graduate School Of Dental Med
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