Changes in saliva interleukin-6 levels in patients with oral squamous cell carcinoma

概要

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Objective: To elucidate the changes in interleukin-6 (IL-6) levels in whole saliva during the treatment phase in patients with oral squamous cell carcinoma (OSCC). Study design: Twenty-nine consecutive inpatients with OSCC were enrolled in this study. Stimulated saliva was collected three times (just after hospitalization)[period 1], just before main treatment (surgery: 26/29 cases)[period 2] and at the time of discharge [period 3]. The mean intervals were 11±8 days between periods 1 and 2 and 30±18 days between periods 2 and 3. As controls, 19 age-matched healthy volunteers were also recruited. IL-6 concentrations were measured by a highly sensitive chemiluminescent enzyme immunoassay. Results: IL-6 was detected in 23/29 samples in the patient group in period 1. The concentration of IL-6 was significantly higher in the patient group (mean: 20.1±36.3 pg/mL) than in the controls (0.6±0.8 pg/mL)(P = 0.003). In the patient group, the mean concentration of IL-6 in period 2 was 43.6±95.6 pg/mL, significantly higher than in period 1 (P=0.002), and 17.1±27.6 pg/mL in period 3 (P=0.52: compared with period 2). Conclusions: IL-6 was up-regulated in saliva in the OSCC patients. IL-6 level tended to increase before treatment, and returned to baseline levels at discharge.