TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells
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概要
- 論文の詳細を見る
The androgen receptor (AR) is a ligand-dependent transcription factor that belongs to the family of nuclear receptors, and its activity is regulated by numerous AR coregulators. AR plays an important role in prostate development and cancer. In this study, we found that TRIM24/transcriptional intermediary factor 1α (TIF1α), which is known as a ligand-dependent nuclear receptor co-regulator, interacts with AR and enhances transcriptional activity of AR by dihydrotestosterone in prostate cancer cells. We showed that TRIM24 functionally interacts with TIP60, which acts as a coactivator of AR and synergizes with TIP60 in the transactivation of AR. We also showed that TRIM24 binds to bromodomain containing 7 (BRD7), which can negatively regulate cell proliferation and growth. A luciferase assay indicated that BRD7 represses the AR transactivation activity upregulated by TRIM24. These findings indicate that TRIM24 regulates AR-mediated transcription in collaboration with TIP60 and BRD7.
著者
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Takeuchi Jin
Department Of Hematology And Rheumatology Nihon University School Of Medicine
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Tanaka J
Stem Cell Transplantation Center Hokkaido University Hospital
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Kondo Takeshi
Stem Cell Transplantation Center Hokkaido University Hospital
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Imamura M
Stem Cell Transplantation Center Hokkaido University Hospital
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Maruta Ichiroh
Department Of Hematology And Oncology Hokkaido University Graduate School Of Medicine
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Tanaka Junji
Stem Cell Transplantation Center Hokkaido University Hospital
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Imamura Masahiro
Department Of Internal Medicine Saiseikai-hita Hospital
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Kondo Takeshi
北海道大学 医学研究科消化器内科学
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Takeuchi Jin
First Department Of Internal Medicine Nihon University School Of Medicine
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Iwahashi Masahiro
Department Of Internal Medicine Saiseikai-hita Hospital
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Imamura M
Department Of Internal Medicine Saiseikai-hita Hospital
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Tanaka Junji
Japan Society For Hematopoietic Cell Transplantation Adult Data Management Committee
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Kikuchi Misato
Department Of Hematology And Oncology Hokkaido University Graduate School Of Medicine
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Kondo Takeshi
Department Of Pathology Laboratory Of Cancer Research Hokkaido University Graduate School Of Medicine
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Tanaka Shinya
Department Of Pathology Laboratory Of Cancer Research Hokkaido University Graduate School Of Medicine
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