Outcome of medium-dose VP-16/CY/TBI superior to CY/TBI as a conditioning regimen for allogeneic stem cell transplantation in adult patients with acute lymphoblastic leukemia
スポンサーリンク
概要
- 論文の詳細を見る
The choice of conditioning regimen before allogeneic stem cell transplantation (SCT) in patients with acute lymphoblastic leukemia (ALL) is important. We retrospectively compared outcomes of medium-dose VP-16/cyclophosphamide/total body irradiation (VP/CY/TBI) regimen and CY/TBI. Five hundred and twenty-nine patients (VP/CY/TBI: n = 35, CY/TBI: n = 494) who met all of the following criteria were compared: first time for SCT, aged 15-59 years; first or second complete remission at SCT; bone marrow or peripheral blood as stem cell source; and HLA phenotypically matched donor. Median age of the patients was 34 years, and patients who received VP/CY/TBI were younger (28 years vs. 34 years, P = 0.02). Cumulative incidences of relapse and non-relapse mortality (NRM) were higher for patients who received CY/TBI (P = 0.01 for relapse, P < 0.01 for NRM). After a median follow-up period of 36.9 months, 5-year overall survival (OS) rates were 82.2% in the VP/CY/TBI group and 55.2% in the CY/TBI group. OS, and disease-free survival (DFS) in the VP/CY/TBI group were shown to be significantly better by multivariate analysis [hazard ratio: 0.21 (95% confidence interval: 0.06-0.49) for DFS, hazard ratio: 0.25 (95% confidence interval: 0.08-0.59) for OS]. VP/CY/TBI was associated with a lower relapse rate and no increase in NRM, resulting in better survival than that in CY/TBI for adult ALL patients.
著者
-
三木 義男
癌研ゲノムセンター
-
Morishima Y
Department Of Hematology Kinki University School Of Medicine
-
Asano Shigetaka
東京大学医科学研究所 血液腫瘍内科
-
Asano Shigetaka
Institute Of Medical Science University Of Tokyo
-
Asano Shigetaka
Department Of Pediatric Hematology/oncology The Institute Of Medical Science The University Of Tokyo
-
Matsumoto-mishima Yuko
癌研究会癌化学療法センター 臨床研究部
-
Imamura M
Stem Cell Transplantation Center Hokkaido University Hospital
-
MITSUI Yoko
Department of Surgery
-
Kobayashi K
Department Of Hematology/oncology Osaka Medical Center And Research Institute For Maternal And Child
-
Asano Shigetaka
Department Of Hematology And Oncology Institute Of Medical Science University Of Tokyo
-
Yoshida Tomotaka
Cellular Transplantation Biology Kanazawa University Graduate School Of Medical Science
-
Imamura Masahiro
Department Of Internal Medicine Saiseikai-hita Hospital
-
Iwahashi Masahiro
Department Of Internal Medicine Saiseikai-hita Hospital
関連論文
- ゲノム情報を生かした個別化医療 (特集 固形癌の最新治療--癌治療への新たな取り組み) -- (治療の新たな取り組み 個別化治療)
- Allogeneic stem cell transplantation versus chemotherapy as post-remission therapy for intermediate or poor risk adult acute myeloid leukemia : results of the JALSG AML97 study
- Randomized trial of response-oriented individualized versus fixed-schedule induction chemotherapy with idarubicin and cytarabine in adult acute myeloid leukemia : the JALSG AML95 study
- Comparative analysis of remission induction therapy for high-risk MDS and AML progressed from MDS in the MDS200 study of Japan Adult Leukemia Study Group
- P-674 大腸癌肝転移切除例のSurgical Marginについての遺伝子学的および組織学的検討
- PP-1137 大腸癌肝転移に対する外科的治療戦略 : Surgical Marginについての遺伝子学的および臨床病理学的検討
- SF-107-4 大腸sm癌のリンパ節転移と遺伝子群のマイクロアレイによる解析(第107回日本外科学会定期学術集会)
- 大腸の増殖形式(PG・NPG)と遺伝子群のマイクロアレイによる解析,悪性度についての検討
- マイクロアレイによる大腸癌の異時性肝転移の高リスク群の抽出
- SY-1-2-5 肝細胞癌の進展機構解析による新規分子標的の同定(シンポジウム1-2 消化器癌の発生機序から見た治療戦略-肝胆膵癌,第62回日本消化器外科学会定期学術総会)
- PS-095-1 n0乳癌における再発予後予測システムの検討
- SY-6-6 癌遺伝子発現パターンを用いたPaclitaxelの治療効果予知 : 局所進行乳癌に対する術前化療による解析
- 早期大腸癌の発育形態と Ras-signaling Pathway 異常(第105回日本外科学会定期学術集会)
- PS-117-2 散発性大腸癌発癌におけるhMLH1発現低下の意義
- Histological and immunophenotypic changes in 59 cases of B-cell non-Hodgkin's lymphoma after rituximab therapy
- Diffuse large B-cell lymphoma after transformation from low-grade follicular lymphoma : morphological, immunohistochemical, and FISH analyses
- Phase I and II pharmacokinetic and pharmacodynamic study of the proteasome inhibitor bortezomib in Japanese patients with relapsed or refractory multiple myeloma
- A-3 インベーダ法によるSNP遺伝子型データの2変量正規混合分布に基づく分類(企画セッション:SNPデータの解析における統計的諸問題)(2003年度統計関連学会連合大会記録(日本統計学会第71回大会))
- Phase II study of tacrolimus and methotrexate for prophylaxis of acute graft-versus-host disease after HLA-A, B, and DRB1 genotypically mismatched unrelated bone marrow transplantation among Japanese patients
- 発がん・増殖 BRCA遺伝子機能とその機能欠損による乳癌発生機序 (乳癌--基礎と臨床の架け橋)
- 図説 最新のゲノムワイド解析技術 (特集 ゲノム研究最前線--疾患ゲノム研究の現状と展望)
- 癌と骨転移のゲノム学 (特集 骨・破壊と再生のゲノム医学)
- 遺伝性乳癌の分子遺伝学--BRCA1を中心に (癌抑制遺伝子--最新トピックス)
- SNPsと有害事象情報 (特集 分子・細胞標的治療--基礎と臨床) -- (基礎)
- がんの遺伝解析 (特集 ポストゲノム時代の医療) -- (ゲノム解析からの病態解明)
- 大腸癌表層部と先進部の発現プロファイル解析
- IS-3-4 乳がん術前化学療法の効果予測システム開発の試み(第108回日本外科会定期学術集会)
- A Japanese patient with Li-Fraumeni syndrome who had nine primary malignancies associated with a germline mutation of the p53 tumor-suppressor gene
- SF-108-2 大腸癌先進部脱分化に関与する遺伝子群の同定と機能ネットワークの構築(第107回日本外科学会定期学術集会)
- O-109 原発性肺癌切除時の開胸時胸腔内洗浄液における微量肺癌細胞の検出と細胞診の比較(肺癌と分子生物学2, 第47回日本肺癌学会総会)
- DP-009-4 包括的遺伝子発現解析による膵癌リンパ節転移予測マーカーの同定(第108回日本外科学会定期学術集会)
- Outcome of allogeneic bone marrow transplantation from unrelated donors for adult Philadelphia chromosome-negative acute lymphocytic leukemia in first complete-remission
- Linkage of expression of chemokine receptors (CXCR3 and CCR4) and cytotoxic molecules in peripheral T cell lymphoma, not otherwise specified and ALK-negative anaplastic large cell lymphoma
- Prognostic analysis and a new risk model for Hodgkin lymphoma in Japan
- Long-term efficacy of imatinib in a practical setting is correlated with imatinib trough concentration that is influenced by body size : a report by the Nagasaki CML Study Group
- Cross-sectional analysis of germline BRCA1 and BRCA2 mutations in Japanese patients suspected to have hereditary breast/ovarian cancer
- Management of infection in patients with acute leukemia during chemotherapy in Japan : questionnaire analysis by the Japan Adult Leukemia Study Group
- A Phase I/II study of nilotinib in Japanese patients with imatinib-resistant or -intolerant Ph+ CML or relapsed/refractory Ph+ ALL
- P-7 原発性肺癌切除時の開胸時胸腔内洗浄液におけるCEA-mRNAの検出の意義(一般演題(ポスター) トランスレーショナルリサーチ,第48回日本肺癌学会総会)
- Phase 1/2 clinical study of dasatinib in Japanese patients with chronic myeloid leukemia or Philadelphia chromosome-positive acute lymphoblastic leukemia
- Japanese phase II study of ^Y-ibritumomab tiuxetan in patients with relapsed or refractory indolent B-cell lymphoma
- Imatinib for newly diagnosed chronic-phase chronic myeloid leukemia : results of a prospective study in Japan
- Phase I/II study of humanized anti-CD33 antibody conjugated with calicheamicin, gemtuzumab ozogamicin, in relapsed or refractory acute myeloid leukemia : final results of Japanese multicenter cooperative study
- Hematopoietic stem cell transplantation for acute promyelocytic leukemia in second or third complete remission : a retrospective analysis in the Nagoya Blood and Marrow Transplantation Group
- Diagnosis of acute myeloid leukemia according to the WHO classification in the Japan Adult Leukemia Study Group AML-97 protocol
- 乳がんのLarge-scale genomic study
- Monosomies 7p and 12p and FLT3 internal tandem duplication : possible markers for diagnosis of T/myeloid biphenotypic acute leukemia and its clonal evolution
- Allelic Losses of Loci at 3p25.1,8p22,13q12,17p13.3,and 22q13 Correlate with Postoperative Recurrence in Breast Cancer
- Successful cord blood transplantation for mycosis fungoides.
- Phase II study of a salvage regimen using cyclophosphamide, high-dose cytarabine, dexamethasone, etoposide, and rituximab in patients with relapsed or refractory B-cell non-Hodgkin's lymphoma
- Primary Hepatic Follicular Lymphoma : A Case Report and Discussion of Chemotherapy and Favorable Outcomes
- HNPCC患者の放射線治療の安全性に関する検討(第105回日本外科学会定期学術集会)
- Histological Features of Breast Cancer, Highly Sensitive to Chemotherapy
- Identifying haplotype block structure using an ancestor-derived model
- Increased incidence of interstitial pneumonia by CHOP combined with rituximab
- Impaired TCR signaling through dysfunction of lipid rafts in sphingomyelin synthase 1 (SMS1)-knockdown T cells
- Safety and efficacy of rasburicase (SR29142) in a Japanese phase II study
- Allelic Loss at 1p34,13q12,17p13.3,and 17q21.1 Correlates With Poor Postoperative Prognosis in Breast Cancer
- Correlation of Allelic Loss with Poor Postoperative Survival in Breast Cancer
- Frequent Allelic Loss at 6q26-27 in Breast Carcinomas of the Solid-tubular Histologic Type
- Correlation of Allelic Losses and Clinicopathological Factors in Primary Breast Cancers
- Mapping of a Breast Cancer Tumor Suppressor Gene Locus to a 4-cM Interval on Chromosome 18q21
- Clinicopathological Features of Hereditary Breast Cancer
- Expression profiling to predict postoperative prognosis for estrogen receptor-negative breast cancers by analysis of 25,344 genes on a cDNA microarray
- Tocilizumab is effective for pulmonary hypertension associated with multicentric Castleman's disease
- Identification of Rad51 alteration in patients with bilateral breast cancer
- High proportion of missense mutations of the BRCA1 and BRCA2 genes in Japanese breast cancer families
- Multiplex Mutation Screening of the BRCA1 Gene in 1000 Japanese Breast Cancers
- Infrequent Mutation of the H-Cadherin Gene on Chromosome 16q24 in Human Breast Cancers
- Circulating tumor cells as a surrogate marker for determining response to chemotherapy in patients with advanced gastric cancer
- Bilateral Nonpalpable Breast Carcinomas in a Patient with BRCA2 Germ Line Mutation and Past History of Osteosarcoma
- Clinical features of adult acute leukemia with 11q23 abnormalities in Japan : a co-operative multicenter study
- 癌抑制遺伝子BRCA1/2の機能およびPARP阻害剤によるBRCA変異陽性乳癌の治療 (特集 癌治療・発癌・老化の鍵を握るDNA修復経路)
- High-resolution melting analysis for a reliable and two-step scanning of mutations in the tyrosine kinase domain of the chimerical bcr-abl gene.
- Autophagy and autophagic cell death are next targets for elimination of the resistance to tyrosine kinase inhibitors
- Continuous treatment of bestatin induces anti-angiogenic property in endothelial cells
- Differential Regulation of Eotaxin-1/CCL11 and Eotaxin-3/CCL26 Production by the TNF-α and IL-4 Stimulated Human Lung Fibroblast(Pharmacology)
- Familial breast and ovarian cancers
- Analysis of extracellular matrix of a skin tumor from patients with juvenile hyaline fibromatosis
- Sentinel Lymph Node Biopsy Using Tin Colloid RI and Blue Dye Method
- Association of Allelic Losses at 3p25.1, 13q12, or 17p13.3 with Poor Prognosis in Breast Cancers with Lymph Node Metastasis
- Allelic Loss at 1p34-36 Predicts Poor Prognosis in Node-negative Breast Cancer
- Clinical Results of Extracorporeal Membrane Oxygenation (ECMO) Support for Acute Respiratory Failure : A Comparison of a Centrifugal Pump ECMO with a Roller Pump ECMO
- Diffuse Sclerosing Variant of Papillary Thyroid Carcinoma : A Case Report
- Two Case of Breast Cancer with Cartilaginous and Osseous Metaplasia
- Long-Term Suppression of Lymphangitic Lung Metastasis from Breast Cancer Using Biweekly Docetaxel : A Case Report
- Thyroid Carcinoma with Internal Jugular Vein Thrombus : Report of a Case
- Breast-Conserving Therapy Versus Modified Radical Mastectomy in the Treatment of Early Breast Cancer in Japan
- Tamoxifen-Failed Male Breast Cancer with a High Level of Circulating Estrogen : Report of a Case
- Recurrence of Breast Cancer Following Local Excision Alone for Ductal Carcinoma in situ
- A Case Report of Advanced Male Breast Cancer with an Objective Response to Tamoxifen Treatment
- Trends of IL-6 and IL-8 Levels in Patients with Recurrent Breast Cancer: Preliminary report
- Percutaneous ethanol injection therapy for patients with inoperable thyroid papillary cancer: a report of two cases
- Surgery for Ductal Carcinoma in situ
- Tolerability and Safety of Classic Cyclophosphamide, Methotrexate, and Fluorouracil Treatment in Japanese Patients with Early Breast Cancer
- Clinical Study on the Metastasis to the Eyes from Breast Cancer
- Phase I study of dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide (SMILE) chemotherapy for advanced-stage, relapsed or refractory extranodal natural killer (NK)/T-cell lymphoma and leukemia
- 遺伝子診断の展望 (乳癌--基礎・臨床研究のアップデート) -- (臨床研究 診断 遺伝子診断)
- マイクロアレイ技術と薬剤感受性評価 (あゆみ 抗癌剤感受性試験の進歩)
- Functional pathway characterized by gene expression analysis of supraclavicular lymph node metastasis-positive breast cancer