Abnormal expansion of naïve B lymphocytes after unrelated cord blood transplantation : a case report
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概要
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A 33-year-old woman underwent unrelated cord blood transplantation (U-CBT) for myelodysplastic syndrome (MDS)-related secondary AML. She showed impressive increases in the number of CD19+ B cells in bone marrow and CD19+27-IgD+ B cells in peripheral blood from about1 month to 3 months after U-CBT. The serum level of IL-6 temporarily increased after transplantation, and this increase seemed to be correlated with the expansion of CD19+ B cells.Although compared with BMT, little is known about the kinetics of hematological and immunological reconstitution in U-CBT, there was initial B-cell recovery after CBT as some described. This B cell recovery may be associated with a high number of B-cell precursors present in cord blood (CB). The phenomenon of naive B lymphocyte expansion that we found might be associated with a high number of B-cell precursors present in CB.
著者
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Ota Shuichi
北海道大学 大学院医学研究科癌診断治療学講座血液内科学分野
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Tanaka J
Stem Cell Transplantation Center Hokkaido University Hospital
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Imamura M
Stem Cell Transplantation Center Hokkaido University Hospital
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Asaka Masahiro
Third Department Of Internal Medicine Hokkaido University Graduate School Of Medicine
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Imamura Masahiro
Department Of Internal Medicine Saiseikai-hita Hospital
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Takeuchi Jin
First Department Of Internal Medicine Nihon University School Of Medicine
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Iwahashi Masahiro
Department Of Internal Medicine Saiseikai-hita Hospital
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Tanaka Junji
Japan Society For Hematopoietic Cell Transplantation Adult Data Management Committee
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Asaka M
Department Of Gastroenterology Hokkaido University Graduate School Of Medicine
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Shono Yusuke
Stem Cell Transplantation Center Hokkaido University Hospital
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Ota Shunichiro
Stem Cell Transplantation Center Hokkaido University Hospital
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Ibata Makoto
Stem Cell Transplantation Center Hokkaido University Hospital
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