Clinical significance of minimal residual disease in adult acute lymphoblastic leukemia
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概要
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Monitoring minimal residual disease (MRD) in patients with acute lymphoblastic leukemia (ALL) is a useful way for assessing treatment response and relapse. We studied the value of MRD and showed a correlation with relapse for 34 adult patients with ALL. MRD was evaluated by real-time quantitative polymerase chain reaction (RQ-PCR) with probes derived from fusion chimeric genes (BCR/ABL) (n = 12) or PCR-based detection of clonal immunoglobulin and T-cell receptor gene rearrangements (n = 16), or both (n = 6). We analyzed 27 of the 34 patients who could be examined for MRD on day 100 after induction therapy. The overall survival (OS) rate (45.0%) and relapse-free survival (RFS) rate (40.0%) at 2 years in CR patients with MRD level ≥ 10^[-3] (n = 12) were significantly lower than those in CR patients with MRD level < 10^[-3] (n = 15) (OS rate: 79.0%, RFS rate: 79.4%) (log-rank test, P = 0.017 and 0.0007). We also applied multicolor flow cytometry for comparison with MRD results analyzed by PCR methods. The comparison of results obtained in 27 follow-up samples showed consistency in 17 samples (63.0%) (P = 0.057). MRD analysis on day 100 is important for treatment decision in adult ALL.
- 2010-10-15
著者
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Kokai Yasuo
札幌医科大学 外科学第一講座
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KUROSAWA Mitsutoshi
Department of Hematology, National Hospital Organization, Hokkaido Cancer Center
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KASAI Masaharu
Department of Hematology, Sapporo Hokuyu Hospital
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Noto Shun
Stem Cell Transplantation Center Hokkaido University Hospital
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Takeuchi Jin
Department Of Hematology And Rheumatology Nihon University School Of Medicine
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Kohgo Yutaka
Fourth Department Of Internal Medicine Sapporo Medical University School Of Medicine
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Fukuhara Takashi
Department Of Internal Medicine Asahikawa City Hospital
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Kurosawa Mitsutoshi
Department Of Hematology National Hospital Organization Hokkaido Cancer Center
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Noto Satoshi
Department Of Viral Oncology Cancer Institute Japanese Foundation For Cancer Research
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Tanaka J
Stem Cell Transplantation Center Hokkaido University Hospital
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Kondo Takeshi
Stem Cell Transplantation Center Hokkaido University Hospital
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Hashino Satoshi
Stem Cell Transplantation Center Hokkaido University Hospital
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ASAKA Masahiro
Third Department of Internal Medicine, Hokkaido University School of Medicine
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Imamura M
Stem Cell Transplantation Center Hokkaido University Hospital
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Imamura Masahiro
Department Of Radiology
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TANAKA Junji
Department of Hematology and Oncology, Hokkaido University Graduate School of Medicine
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HASHINO Satoshi
Third Department of Internal Medicine
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Kohgo Yutaka
The Third Department Of Internal Medicine Asahikawa Medical College
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Kawano Y
Fourth Department Of Internal Medicine Sapporo Medical University School Of Medicine
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Asaka Masahiro
Third Department Of Internal Medicine Hokkaido University Graduate School Of Medicine
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Kawamura Takahito
Department Of Medicine Ii Hokkaido University Graduate School Of Medicine
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Kohgo Yutaka
旭川医科大学 消化器･血液腫瘍制御内科学
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Maruta Ichiroh
Department Of Hematology And Oncology Hokkaido University Graduate School Of Medicine
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Kakinoki Yasutaka
Department of Internal Medicine, Asahikawa Kosei Hospital
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Masauzi Nobuo
Department of Hematology, Hakodate City Hospital
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Sato Norihiro
Translational Research And Clinical Trial Center Hokkaido University Hospital
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Tanaka Junji
Stem Cell Transplantation Center Hokkaido University Hospital
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MORIOKA Masanobu
Department of Internal Medicine, Aiiku Hospital
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Kasai Masaharu
Department Of Hematology Sapporo Hokuyu Hospital
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Imamura Masahiro
Department Of Internal Medicine Saiseikai-hita Hospital
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Tanaka Junji
Department Of Clinical Laboratory Science Graduate Course Of Medical Science And Technology Division
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Kondo Takeshi
北海道大学 医学研究科消化器内科学
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Imamura Masahiro
Department Of Environmental Science Central Research Institute Of Electric Power Industry (criepi)
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Takeuchi Jin
First Department Of Internal Medicine Nihon University School Of Medicine
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Masauzi Nobuo
Department Of Internal Medicine Hakodate Municipal Hospital
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Kondo Takeshi
Third Department of Internal Medicine, Showa University School of Medicine
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Kakinoki Yasutaka
Department Of Internal Medicine Asahikawa Kosei Hospital
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Iwahashi Masahiro
Department Of Internal Medicine Saiseikai-hita Hospital
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Asaka Masahiro
Hokkaido Univ. School Of Medicine Sapporo Jpn
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Iwasaki Hiroshi
Second Department of Medicine, Yamanashi Medical University
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Kondo Takeshi
Department Of Medicine Ii Hokkaido University Graduate School Of Medicine
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Imamura M
Department Of Internal Medicine Saiseikai-hita Hospital
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Kazumata Mika
Hokkaido Univ. Sapporo Jpn
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Kondo Takeshi
Department Of Gastroenterology And Hematology Hokkaido University Graduate School Of Medicine
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Shimoyama Norihiko
Department Of Clinical Pathology Hakodate Municipal Hospital
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Tanaka Junji
Japan Society For Hematopoietic Cell Transplantation Adult Data Management Committee
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KIKUCHI Misato
Department of Hematology and Oncology, Hokkaido University Graduate School of Medicine
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KAWAMURA Tsugumichi
Department of Internal Medicine, Hakodate Central Hospital
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KOBAYASHI Hajime
Fourth Department of Internal Medicine, Obihiro Kosei Hospital
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Musashi M
Department Of Internal Medicine Aiiku Hospital
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Iwasaki Hiroshi
Second Department Of Internal Medicine Sapporo Kosei Hospital
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Kobayashi Hajime
Fourth Department Of Internal Medicine Obihiro Kosei Hospital
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Kikuchi Misato
Department Of Hematology And Oncology Hokkaido University Graduate School Of Medicine
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Masauji Nobuo
Department Of Hematology Hakodate City Hospital
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Asaka M
Department Of Gastroenterology Hokkaido University Graduate School Of Medicine
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Morioka Masanobu
Department Of Internal Medicine Aiiku Hospital
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Kasai Masaharu
Department Of Anatomic And Diagnostic Pathology Dokkyo University School Of Medicine
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Kondo Takeshi
Department Of Pathology Laboratory Of Cancer Research Hokkaido University Graduate School Of Medicine
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Tanaka Shinya
Department Of Pathology Laboratory Of Cancer Research Hokkaido University Graduate School Of Medicine
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FUKUHARA Takashi
Department of Hematology, Asahikawa City Hospital
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