Effect of granulocyte colony-stimulating factor on IL-12 p40 production during chemotherapy for B-cell lineage non-Hodgkin's lymphoma patients

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概要

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• Interleukin (IL)-12 is a 70-kDa cytokine comprised of two disulfide-linked proteins (p35 and p40) and is essential for the initiation of effective immune response. Granulocyte-colony stimulating factor (G-CSF) affects the balance in the production of anti-inflammatory cytokines. We investigated the serum IL-12 p40 and IL-12 Mix (p40 and p70) production in 28 patients with B-cell lineage non-Hodgkin's lymphoma (NHL) treated with chemotherapy (e.g., CHOP regimen) with or without G-CSF administration and eight healthy volunteers. We found that serum levels of IL-12 p40 (191.2 ± 150.0 pg/mL) and IL-12 Mix (277.4 ± 274.5 pg/mL) in the patients before chemotherapy were higher than those in the healthy volunteers (IL-12 p40: 76.4 ± 25.3 pg/mL, IL-12 Mix: 48.5 ± 33.4 pg/mL) (P = 0.04 and 0.02, respectively). Next, we examined the serum IL-12 p40 and IL-12 Mix levels in nine patients receiving chemotherapy with administration of G-CSF (CG group, n = 9) and without G-CSF (C group, n = 9). Serum IL-12 p40 and IL-12 Mix levels were decreased on 10 d after chemotherapy in both groups, and those in CG groups were significantly lower than those in C group. These results indicated that administration of G-CSF decreased serum IL-12 p40 and IL-12 Mix levels. Overall survival (OS) at 24 months was not significantly different in the two groups (58.3% in group C vs. 80.0% in group CG, P = 0.67). However, the survival rate of patients at clinical stages III and IV in CG group (n = 6, 66.0%) was significantly better than that of patients in C group (n = 4, 25.0%) (P = 0.02). Long-term administration of G-CSF appears to influence the survival rate by reducing immunosuppressive IL-12 p40 production.

• Blackwell Publishingの論文

著者

• Kokai Yasuo

  札幌医科大学 外科学第一講座

• KASAI Masaharu

  Department of Hematology, Sapporo Hokuyu Hospital

• Kohgo Yutaka

  Fourth Department Of Internal Medicine Sapporo Medical University School Of Medicine

• Fukuhara Takashi

  Department Of Internal Medicine Asahikawa City Hospital

• Kurosawa Mitsutoshi

  Department Of Hematology National Hospital Organization Hokkaido Cancer Center

• Ota Shuichi

  北海道大学 大学院医学研究科癌診断治療学講座血液内科学分野

• Tanaka J

  Stem Cell Transplantation Center Hokkaido University Hospital

• Kondo Takeshi

  Stem Cell Transplantation Center Hokkaido University Hospital

• Hashino Satoshi

  Stem Cell Transplantation Center Hokkaido University Hospital

• Imamura M

  Stem Cell Transplantation Center Hokkaido University Hospital

• Kohgo Yutaka

  The Third Department Of Internal Medicine Asahikawa Medical College

• Kawano Y

  Fourth Department Of Internal Medicine Sapporo Medical University School Of Medicine

• Asaka Masahiro

  Third Department Of Internal Medicine Hokkaido University Graduate School Of Medicine

• Kawamura Takahito

  Department Of Medicine Ii Hokkaido University Graduate School Of Medicine

• Kohgo Yutaka

  旭川医科大学 消化器･血液腫瘍制御内科学

• MORIOKA Masanobu

  Department of Internal Medicine, Aiiku Hospital

• Imamura Masahiro

  Department Of Internal Medicine Saiseikai-hita Hospital

• Kondo Takeshi

  北海道大学 医学研究科消化器内科学

• Takeuchi Jin

  First Department Of Internal Medicine Nihon University School Of Medicine

• Masauzi Nobuo

  Department Of Internal Medicine Hakodate Municipal Hospital

• Iwahashi Masahiro

  Department Of Internal Medicine Saiseikai-hita Hospital

• Kondo Takeshi

  Department Of Medicine Ii Hokkaido University Graduate School Of Medicine

• Kazumata Mika

  Hokkaido Univ. Sapporo Jpn

• Tanaka Junji

  Japan Society For Hematopoietic Cell Transplantation Adult Data Management Committee

• Musashi M

  Department Of Internal Medicine Aiiku Hospital

• Kobayashi Hajime

  Fourth Department Of Internal Medicine Obihiro Kosei Hospital

• Masauji Nobuo

  Department Of Hematology Hakodate City Hospital

• Asaka M

  Department Of Gastroenterology Hokkaido University Graduate School Of Medicine

• Shono Yusuke

  Stem Cell Transplantation Center Hokkaido University Hospital

• Morioka Masanobu

  Department Of Internal Medicine Aiiku Hospital

• Ota Shunichiro

  Stem Cell Transplantation Center Hokkaido University Hospital

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