Osteopontin Expression May Be Induced by c-Src in Papillary Thyroid Carcinoma
スポンサーリンク
概要
- 論文の詳細を見る
Osteopontin (OPN), a secreted adhesive glycoprotein, is significantly overexpressed in a variety of malignant tumors. Moreover, increased levels of OPN have been detected in the blood of patients with metastatic carcinoma. On immunohistochemical examination, OPN was shown to be expressed in papillary thyroid carcinoma. To investigate the mechanisms of the induction of OPN expression in papillary thyroid carcinoma, we examined the expression of c-src and OPN in 30 cases of papillary thyroid carcinoma by Northern blotting, Western blottimg, in situ hybridization and immunohistochemistry. Each of 5 cases studied by Northern and Western blotting analyses revealed substantial increases of c-src and OPN mRNA and protein levels in tumor areas as compared with surrounding normal thyroid tissues. Moreover, signals of c-src and OPN mRNA were detected in both infiltrating mononuclear cells and tumor cells by in situ hybridization. Immunohistochemical localizations of c-Src and OPN proteins were the same as those of transcripts described above. These results suggested that the induction of the expression of OPN invasiveness in papillary thyroid carcinoma was one of the important downstream events of increased c-Src expression.
- 日本組織細胞化学会の論文
著者
-
Kobayashi Makio
Department of Pathology, Tokyo Women’s Medical University
-
Sato Kanji
Department Of Medicine Institute Of Clinical Endocrinology Tokyo Women's Medical University
-
Sato Kanji
東京女子医科大学 病理
-
Kato Yasuko
Department Of Anatomy Yamanashi Medical University
-
Kato Yuzuru
Department Of Medicine Shimane Medical University
-
KATO Yoichiro
Department of Pathology, Tokyo Women's Medical University
-
OBARA TAKAO
Department of Endocrine Surgery, Tokyo Women's Medical University
-
Obara T
Department Of Endocrine Surgery Tokyo Women's Medical University
-
Obara T
Department Of Endocrine Surgery Tokyo Women's Medical College
-
Obara Takao
Department Of Endocrine Surgery Tokyo Women's Medical College
-
Okamoto T
Department Of Endocrine Surgery Tokyo Women's Medical University
-
Sato Kanji
Department Of Medicine Tokyo Women's Medical University
-
Kato Y
Department Of Pathology Tokyo Women's Medical University
-
TANAKA Reiko
Department of Infections, Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba Univer
-
Kato Yoichiro
Department Of Pathology Tokyo Women's Medical University
-
Kobayashi Masatoshi
Department Of Anatomy & Histology Kurume University School Of Medicine
-
Kobayashi Makio
Department Of Pathology Tokyo Women's Medical College
-
Kobayashi Makio
Dept. Of Pathology Tokyo Women's Medical University
-
Kobayashi Makio
東京女子医科大学 消化器内科学
-
Sato Kanji
Department Of Medicine Institute Of Clinical Endocrinology Tokyo Women's Medical College
-
Sato Katsuyuki
Department Of Medicine Tokyo Women's Medical University
-
Zhu Huagang
Department of General Surgery, First Affiliated Hospital of Anhui Medical University
-
Kobayashi M
Departments Of Pathology Tokyo Women
-
Kato Y
Tokyo Women's Medical Univ.
-
Tnaka Reiko
Department Of Endocrine Surgery Tokyo Women's Medical University
-
Obara T
Department Of Surgery Institute Of Clinical Endocrinology Tokyo Women's Medical University
-
Zhu Huagang
Department Of General Surgery First Affiliated Hospital Of Anhui Medical University:department Of En
-
Kobayashi M
Aska Pharmaceutical Co. Ltd. Research & Development Division
-
Kobayashi Makio
Department Of Immunology And Pathology Yamanashi Medical College
-
Tanaka Reiko
Department Of Endocrine Surgery Tokyo Women's Medical College
-
Kobayashi Makio
Department of Agricultural Chemistry, Faculty of Agriculture, Hokkaido University
関連論文
- F-3 Living Salmonella administration induces an acute reduction in wheel-running activity via TLR5 but not TLR4 in mice(Free communication (Slide),8^ INTERNATIONAL SOCIETY OF EXERCISE AND IMMUNOLOGY SYMPOSIUM,ISEI2007 INFLAMMATION IN EXERCISE FRIEND O
- Potential Involvement of the Stem Cell Factor Receptor c-kit in Alopecia Areata and Androgenetic Alopecia: Histopathological, Immunohistochemical, and Semiquantitative Investigations
- Late Progression After Sirolimus-Eluting Stent Implantation for de Novo Lesions : Comparison With Bare Metal Stent Implantation
- Increased Thyroid Blood Flow in the Hypoechoic Lesions in Patients with Recurrent, Painful Hashimoto's Thyroiditis at the Time of Acute Exacerbation
- Long-term follow-up after implantation of defibrillator in Brugada syndrome
- Radiofrequency catheter ablation for idiopathic ventricular fibrillation and polymorphic ventricular tachycardia
- Recombinant Human Interleukin-11 Decreases Severity of Acute Necrotizing Pancreatitis in Mice
- Intrahepatic biliary epithelial cell damage and inflammation in portal tract in association with chronic colitis-harboring TCRα^ mice
- A case of malignant pheochromocytoma
- Biliary Tract Involvement in Autoimmune Pancreatitis
- Digestion and Gastrointestinal Absorption of the 14-16-kDa Rice Allergens
- QUANTITATIVE ULTRASTRUCTURAL CHANGES IN RAT PROLACTIN CELLS : RELATIONSHIP TO THE REBOUND IN SERUM PROLACTIN LEVELS AFTER BROMOCRIPTINE TREATMENT
- SENSITIVE IMMUNOHISTOCHEMICAL DEMONSTRATION OF ENDOGENOUS PROLACTIN IN MAMMARY GLAND AND DMBA-INDUCED MAMMARY CARCINOMA OF RATS BY ABC METHOD
- An Instructive Case Suggesting Cyclical Primary Hyperparathyroidism
- Immunohistochemical Study of Obliterated Arteriovenous Malformations after Gamma Knife Radiosurgery
- The Relationship between Serum Levels of Estradiol and Osteoprotegerin in Patients with Anorexia Nervosa
- An Assessment of Bone Mineral Density in Patients with Addison's Disease and Isolated ACTH Deficiency Treated with Glucocorticoid
- Degradation of Soluble Proteins Including Some Allergens in Brown Rice Grains by Endogenous Proteolytic Activity during Germination and Heat-Processing
- Hypercalcemia in an Enthyroid Patient with Secondary Hypoadrenalism and Diabetes Insipidus due to Hypothalamic Tumor
- Cardiac Malignant Pheochromocytoma with Bone Metastases
- Osteo-Anabolic Effects of Human Growth Hormone with 22K- and 20K Daltons on Human Osteoblast-Like Cells
- Pathological Finding of Sirolimus-Eluting Stent (SES) Restenosis Lesion With Black Hole Appearance on Intravascular Ultrasound
- OE-015 Impact of Chronic Kidney Disease and Diabetes on Long-Term Prognosis in Patients with Primary Angioplasty for Acute Coronary Syndrome(Acute coronary syndrome, basic/clinical(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of
- Ultrasonographic Features of Parathyroid Carcinoma
- INVERSE CORRELATION BETWEEN THYROID PEROXIDASE (TPO) AND GAMMA-GLUTAMYL TRANSPEPTIDASE (GGT) ACTIVITIES EXPRESSED IN DIISOPROPANOLNITROSAMINE (DIPN) INDUCED RAT THYROID LESIONS : AN ENZYME HISTOCHEMICAL STUDY
- Effects of the PPARγ activator pioglitazone on p38 MAP kinase and IκBα in the spinal cord of a transgenic mouse model of amyotrophic lateral sclerosis
- Protein-bound crotonaldehyde accumulates in the spinal cord of superoxide dismutase-1 mutation-associated familial amyotrophic lateral sclerosis and its transgenic mouse model
- Intracellular binding of fukutin and α-dystroglycan : Relation to glycosylation of α-dystroglycan
- WS1-3 Accumulation of protein-bound crotonaldehyde in the spinal cord of a transgenic mouse model of amyotrophic lateral sclerosis(THE 46TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- Clinicopathological study on eyes from cases of Fukuyama type congenital muscular dystrophy
- Unique astrocytic inclusion in a 2 month-old baby showing Leigh-like brain lesions with lactic acidosis
- P-39 Continuous expression of c-jun and c-fos oncogene in developmental stage of rat brain
- Early stage of human adenovirus type 12-inoculated retinal tissue of F344 newborn rat
- Embryological Fusion Between the Ducts of the Ventral and Dorsal Primordia of the Pancreas Occurs in Two Manners
- Expression of Thyroid Transcription Factor-1(TTF-1)in Human C Cells and Medullary Thyroid Carcinomas
- Gene Expression of type II and type X Collagen in Endochondral Ossification
- Follow-up study after cardioverter-defibrillator implantation for primary prevention of sudden cardiac death
- Significance of signal averaged electrocardiography for predicting electrical storm in implantable cardioverter defibrillator patients with left ventricular dysfunction
- Methods of provocation for idiopathic ventricular tachycardia originating from the outflow tract of right ventricular
- Electrophysiological properties and catheter ablation of cavotricuspid isthmus-independent atrial tachyarrhythmias
- Clinical significance of supraventricular arrhythmia in arrhythmogenic right ventricular dysplasia
- Risk of sudden cardiac death in patients with non-sustained ventricular tachycardia and structural heart disease
- Pial-glial barrier abnormalities in fetuses with Fukuyama congenital muscular dystrophy
- Fukuyama congenital muscular dystrophy: Cortical dysplasia of the cerebrum in a 20 week fetus
- Mild and Short Recurrence of Type II Amiodarone-induced Thyrotoxicosis in Three Patients Receiving Amiodarone Continuously for More Than 10 Years
- Stimulating parathyroid cell proliferation and PTH release with phosphate in organ cultures obtained from patients with primary and secondary hyperparathyroidism for a prolonged period
- Rapid Differential Diagnosis of Graves' Disease and Painless Thyroiditis Using Total T3/T4 Ratio, TSH, and Total Alkaline Phosphatase Activity
- Hypercalcemia Induced by Excessive Intake of Calcium Supplement, Presenting Similar Findings of Primary Hyperparathyroidism
- A Novel Missense Mutation of AIRE Gene in a Patient with Autoimmune Polyendocrinopathy, Candidiasis and Ectodermal Dystrophy (APECED), Accompanied with Progressive Muscular Atrophy : Case Report and Review of the Literature in Japan
- Amiodarone-Induced Thyroid Dysfunction and Ventricular Tachyarrhythmias During Long-Term Therapy in Japan
- Clinical Characteristics of Amiodarone-Induced Thyrotoxicosis and Hypothyroidism in Japan
- Vibration analysis of obturator prostheses with different bulb height designs
- Prevalence of herpesviridae and hepatitis virus sequences in the livers of patients with fulminant hepatitis of unknown etiology in Japan
- Outcome of Breast-Conserving Therapy in the Tokyo Women's Medical University Breast Cancer Society Experience
- F-22 The different effects of exhaustive exercise on poly I:C-induced IFN-β and TNF-α productions in mice(Free communication (Slide),8^ INTERNATIONAL SOCIETY OF EXERCISE AND IMMUNOLOGY SYMPOSIUM,ISEI2007 INFLAMMATION IN EXERCISE FRIEND OR FOE?)
- Expression of Vascular Endothelial Growth Factor (VEGF) and Specific Receptors (Flt-1 and Flk-1) in Rat Tongue Carcinogenesis Induced by 4-Nitroquinoline 1-Oxide
- Immunohistochemical Localization of Copper-Zinc and Manganese Superoxide Dismutases in Human Tissues
- Immunohistochemical localization of superoxide dismutase (SOD) in the background lesions of diisopropanolnitrosamine (DIPN) induced rat thyroid tumor
- The alteration of retinal superoxide dismutase(SOD) in streptozotocin(STZ)-induced diabetic rats : Immunohistochemical study
- Clinical Significance of Hepatocyte Growth Factor and Its Specific Receptor c-Met Expression in Colorectal Cancer Progression
- Osteopontin Expression May Be Induced by c-Src in Papillary Thyroid Carcinoma
- Osteopontin Expression in Papillary Thyroid Carcinoma
- A-35 Electron microscopic replica immunostaining analysis of splenic AA amyloid fibrils in serum amyloid P (SAP) component-deficient mice
- Immunohistochemical Study of Splenic Amyloid Deposits in Serum Amyloid P Component(SAP)-deficient Mice.
- Dystrobrevin localization in various ocular tissues and cerebellum of rats revealed by immunoelectron microscopy
- Scanning electron microscopic study of erythrocyte shapes artificially jetted through tubes at different pressures by 'in vitro cryotechnique for erythrocytes'
- Scanning electron microscopic study of flowing erythrocytes in hepatic sinusoids as revealed by 'in vivo cryotechnique'
- Effect of Carbon/Nitrogen Ratio on Encystment Accompanied with Astaxanthin Formation in a Green Alga, Haematococcus pluvialis
- An Endothelial Nitric Oxide Synthase Inhibitor Aggravates CDL-Induced Acute Pancreatitis in Rats
- Clinicopathological Factors Influencing the Apparent Diffusion Coefficients Obtained by Diffusion-weighted Magnetic Resonance Imaging in Patients with Colorectal Cancer
- Gestational Thyrotoxicosis with Acute Wernicke Encephalopathy: A Case Report
- Saccharated Ferric Oxide-Induced Osteomalacia in Japan: Iron-Induced Osteopathy Due to Nephropathy
- Primary mucosa-associated lymphoid tissue-type lymphoma arising in the kidney
- Vascular Endothelial Growth Factors and Thyroid Disorders
- Molecular biological approaches to neurological disorders including knockout and transgenic mouse models
- Small-bowel hemorrhage caused by cytomegalovirus vasculitis following fulminant hepatitis
- Successful treatment of postsurgical hypoparathyroidism by intramuscular injection of vitamin D_3 in a patient associated with malabsorption syndrome due to multiple abdominal surgeries
- Apoptosis in metastatic carcinoma of the central nervous system
- Activation of the Non-receptor Tyrosine Kinase cSrc in Macrophage-rich Atherosclerotic Plaques of Human Carotid Arteries
- Glyoxal inactivates glutamate transporter-1 in cultured rat astrocytes
- Pathological and immunohistochemical findings of an autopsy case of adult moyamoya disease
- Pur α Protein Implicated in Dendritic RNA Transport Interacts with Ribosomes in Neurosal Cytoplasm
- A-40 Retinal opsin mRNA in situ hybridization in the monkey retina.
- Immunohistochemical Detection of Retinal Cones in Monkey Retina : Light and Electron Microscopic Study
- Morphological Aspects of Superoxide Dismutase-1 Mutation in Amyotrophic Lateral Sclerosis and its Transgenic Mouse Model (Symposium VIIHistochemistry for Neuroscience Research)
- Effects of Light Intensity, Light Quality, and Illumination Cycle on Astaxanthin Formation in a Green Alga, Haematococcus pluvialis
- Growth and Astaxanthin Formation of Haematococcus pluvialis in Heterotrophic and Mixotrophic Conditions
- Astaxanthin Production by a Green Alga, Haematococcus pluvialis Accompanied with Morphological Changes in Acetate Media
- A Case of Contact Urticaria from Hydroxypropyltrimonium Hydrolyzed Collagen
- Occipital Lobe Ependymal Cyst
- IMMUNOCYTOCHEMICAL EVIDENCE OF NEURON SPECIFIC ENOLASE (NSE) IN HUMAN ADENOVIRUS 12-INDUCED RETINOBLASTOMA-LIKE TUMOR CELLS IN VITRO
- Primary Leiomyosarcoma of the Breast Treated by Partial Resection of the Breast Including Nipple and Areola : Report of a Case
- Impact of ω-5 Gliadin on Wheat-Dependent Exercise-Induced Anaphylaxis in Mice
- Fukutin expression in mouse non-muscle somatic organs : its relationship to the hypoglycosylation of α-dystroglycan in Fukuyama-type congenital muscular dystrophy
- Chronological Expression and its Significance of c-jun and c-fos mRNA in Rat Brain
- Ovomucoid Rendered Insoluble by Heating with Wheat Gluten but not with Milk Casein
- Effects of the Glycoprotein Sugar Chains on the Amino-Carbonyl Reaction of Chicken and Japanese Quail Ovomucoids With Glucose
- A Preliminary Report on Investigations at Institutions for the Elderly in Shanghai, China and Okayama, Japan : What is Becoming Old?
- A Novel and Simple Method of Insolubilization of Ovomucoid in Cookies Prepared from Batter Containing Egg White
- Vitamin D deficiency in two young adults with biochemical findings resembling pseudohypoparathyroidism type I and type II