Osteopontin Expression in Papillary Thyroid Carcinoma

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概要

• 論文の詳細を見る

• Osteopontin (OPN) is a secreted, adhesive glycophosphoprotein that has been implicaed in both normal and pathologic processes. In recent years, it has been suggested that OPN expression also plays an important role in tumorgenesis, tumor progression and tumor metastasis. To investigate OPN expression in papillary thyroid carcinoma, thirty paraffin sections of papillary thyroid carcinoma confirmed pathologically were examined by immunohistochemistry and in situ hybridization. Immunopositive reactions for OPN-protein were obtained in the nuclear and perinuclear area in all cases. OPN mRNA was expressed in the carcinoma cells around the microcalcifications. The results demonstrated that OPN mRNA is expressed not only by the infiltrated macrophages but also by the papillary thyroid cancer cells. Hence, OPN expression can be considered a pathological feature of papillary thyroid carcinoma and further study into the relation between OPN and the biological behavior of papillary thyroid carcinoma is warranted.

• 日本組織細胞化学会の論文

著者

• Kobayashi Makio

  Department of Pathology, Tokyo Women’s Medical University

• Sato Kanji

  Department Of Medicine Institute Of Clinical Endocrinology Tokyo Women's Medical University

• Sato Kanji

  東京女子医科大学 病理

• Kato Yasuko

  Department Of Anatomy Yamanashi Medical University

• Kato Yuzuru

  Department Of Medicine Shimane Medical University

• KATO Yoichiro

  Department of Pathology, Tokyo Women's Medical University

• OBARA TAKAO

  Department of Endocrine Surgery, Tokyo Women's Medical University

• Obara T

  Department Of Endocrine Surgery Tokyo Women's Medical University

• Obara T

  Department Of Endocrine Surgery Tokyo Women's Medical College

• Obara Takao

  Department Of Endocrine Surgery Tokyo Women's Medical College

• Okamoto T

  Department Of Endocrine Surgery Tokyo Women's Medical University

• Sato Kanji

  Department Of Medicine Tokyo Women's Medical University

• Kato Y

  Department Of Pathology Tokyo Women's Medical University

• Kato Yoichiro

  Department Of Pathology Tokyo Women's Medical University

• Kobayashi Masatoshi

  Department Of Anatomy & Histology Kurume University School Of Medicine

• Kobayashi Makio

  Department Of Pathology Tokyo Women's Medical College

• Kobayashi Makio

  Dept. Of Pathology Tokyo Women's Medical University

• Sato Kanji

  Department Of Medicine Institute Of Clinical Endocrinology Tokyo Women's Medical College

• Sato Katsuyuki

  Department Of Medicine Tokyo Women's Medical University

• Zhu Huagang

  Department of General Surgery, First Affiliated Hospital of Anhui Medical University

• Tnaka Reiko

  Department of Endocrine Surgery, Tokyo Women's Medical University

• Kobayashi M

  Departments Of Pathology Tokyo Women

• Kato Y

  Tokyo Women's Medical Univ.

• Tnaka Reiko

  Department Of Endocrine Surgery Tokyo Women's Medical University

• Obara T

  Department Of Surgery Institute Of Clinical Endocrinology Tokyo Women's Medical University

• Zhu Huagang

  Department Of General Surgery First Affiliated Hospital Of Anhui Medical University:department Of En

• Kobayashi M

  Aska Pharmaceutical Co. Ltd. Research & Development Division

• Kobayashi Makio

  Department Of Immunology And Pathology Yamanashi Medical College

• Kobayashi Makio

  Department of Agricultural Chemistry, Faculty of Agriculture, Hokkaido University

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