TZT-1027, an Antimicrotubule Agent, Attacks Tumor Vasculature and Induces Tumor Cell Death
スポンサーリンク
概要
- 論文の詳細を見る
- 2000-08-31
著者
-
Mikami T
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
-
Tagawa Masashi
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
-
Watanabe Junichi
Aska Pharmaceutical Co. Ltd. Research & Development Division
-
Kobayashi Masatoshi
Department Of Anatomy & Histology Kurume University School Of Medicine
-
Kobayashi Makio
Dept. Of Pathology Tokyo Women's Medical University
-
Kobayashi Makio
東京女子医科大学 消化器内科学
-
NAKAYAMA Takaharu
Safety Res. Dept., Teikoku Hormone Mfg. Co., Ltd., of Kanagawa Pref.
-
Kobayashi M
Departments Of Pathology Tokyo Women
-
MURAKOSHI Masanori
Safety Research Department, Teikoku Hormone Mfg. Co., Ltd.
-
Murakoshi M
(present Address)products Strategy Dcpartment Pharma Business Strategy Division Teikoku Hormone Mfg.
-
Watanabe Jun
Department Of Pathology School Of Medicine Kitasato University
-
Ohtani Masashi
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
-
Murakoshi Masanori
Safety Res. Dept. Teikoku Hormone Mfg Co. Ltd.
-
Mikami T
Department Of Drug Safety Research Eisai Kawashima Research Laboratories Eisai Co. Ltd.
-
Nakayama Takaharu
Medicinal Research Department Teikoku Hormone Mfg. Co. Ltd.
-
Nakayama Takaharu
Safety Res. Dept. Teikoku Hormone Mfg. Co. Ltd. Of Kanagawa Pref.
-
OTANI Masashi
Safety Research Department, Teikoku Hormone Mfg. Co., Ltd.
-
NATSUME Tsugitaka
Pharmacological Research Department, Teikoku Hormone Mfg. Co., Ltd.
-
WATANABE Jun-ichi
Pharmacological Research Department, Teikoku Hormone Mfg. Co., Ltd.
-
KOBAYASHI Motohiro
Pharmacological Research Department, Teikoku Hormone Mfg. Co., Ltd.
-
MIKAMI Takashi
Safety Research Department, Teikoku Hormone Mfg. Co., Ltd.
-
Natsume Tsugitaka
Teikoku Hormone Mig. Co. Ltd.
-
Kobayashi M
Aska Pharmaceutical Co. Ltd. Research & Development Division
-
Nakayama T
Aska Pharmaceutical Co. Ltd. Research & Development Division
関連論文
- Antitumor activity of TZT-1027 (Soblidotin) against vascular endothelial growth factor-secreting human lung cancer in vivo
- Seasonal Variation of Trace Element Loss to Sweat during Exercise in Males
- Concentrations of Trace Elements in Sweat during Sauna Bathing
- Isoflavone, polymorphisms in estrogen receptor genes and breast cancer risk in case-control studies in Japanese, Japanese Brazilians and non-Japanese Brazilians
- Intrahepatic biliary epithelial cell damage and inflammation in portal tract in association with chronic colitis-harboring TCRα^ mice
- Impact of the revision of a nutrient database on the validity of a self-administered food frequency questionnaire (FFQ)
- Immunohistochemical localization of tubulin in ischemic retina of grebils
- Synergistic up-regulation of Hexokinase-2, glucose transporters and angiogenic factors in pancreatic cancer cells by glucose deprivation and hypoxia
- Hypoxia suppresses the production of matrix metalloproteinases and migration of human monocyte-derived dendritic cells
- Effects of the PPARγ activator pioglitazone on p38 MAP kinase and IκBα in the spinal cord of a transgenic mouse model of amyotrophic lateral sclerosis
- Protein-bound crotonaldehyde accumulates in the spinal cord of superoxide dismutase-1 mutation-associated familial amyotrophic lateral sclerosis and its transgenic mouse model
- Intracellular binding of fukutin and α-dystroglycan : Relation to glycosylation of α-dystroglycan
- WS1-3 Accumulation of protein-bound crotonaldehyde in the spinal cord of a transgenic mouse model of amyotrophic lateral sclerosis(THE 46TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- Clinicopathological study on eyes from cases of Fukuyama type congenital muscular dystrophy
- Unique astrocytic inclusion in a 2 month-old baby showing Leigh-like brain lesions with lactic acidosis
- P-39 Continuous expression of c-jun and c-fos oncogene in developmental stage of rat brain
- Early stage of human adenovirus type 12-inoculated retinal tissue of F344 newborn rat
- II-B-23 Study of development of enteric nerve network structure in the embrionic ret intestine using confocal laser scanning microscopy(THE 45TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- P3-15 Relationship between proliferation of endoplasmic reticulum and induction of CYP2B1/2 in liver lobules of phenobarbital-treated rats
- Changes in density of cytochrome P450 2B1/2 molecules in the membrane of endoplasmic reticulum in hepatocytes of phenobarbital-treated rats
- Examination of an accuracy of quantitative chemiluminescent imaging for histochemistry
- THE EXISTENCE OF MULTI-ENDOCRINE CELLULAR ANTIGEN (MECA) IN THE ACTH-PRODUCING CELLS OF THE GERBIL ADENOHYPOPHYSIS : CONFOCAL LASER SCANNING MICROSCOPIC ANALYSIS
- P-31 MULTI-ENDOCRINE CELLULAR ANTIGEN (MECA) COEXISTS WITH SPECIFIC HORMONE IN THE ENDOCRINE SYSTEM
- P-30 The induction and regulation of CYP1A1 expression induced by 3 methylcholanthrene treatment on cultured hepatoma cell lines.
- A-4 A sensitive and quantitative immunohistochemical method with chemiluminescence
- Pial-glial barrier abnormalities in fetuses with Fukuyama congenital muscular dystrophy
- Fukuyama congenital muscular dystrophy: Cortical dysplasia of the cerebrum in a 20 week fetus
- Expression of Vascular Endothelial Growth Factor (VEGF) and Specific Receptors (Flt-1 and Flk-1) in Rat Tongue Carcinogenesis Induced by 4-Nitroquinoline 1-Oxide
- STUDIES ON EXPERIMENTAL IODINE ALLERGY : 3. LOW MOLECULAR WEIGHT ELICITOGENIC ANTIGENS OF IODINE ALLERGY
- STUDIES ON EXPERIMENTAL IODINE ALLERGY : 2. IODINATED PROTEIN ANTIGENS AND THEIR GENERATION FROM INORGANIC AND ORGANIC IODINE-CONTAINING CHEMICALS
- STUDIES ON EXPERIMENTAL IODINE ALLERGY : 1. ANTIGEN RECOGNITION OF GUINEA PIG ANTI-IODINE ANTIBODY
- Qualitative and Quantitative Assessment of Modified In Situ Reverse Transcription-Polymerase Chain Reaction (In Situ RT-PCR) Method
- Immunohistochemical Localization of Copper-Zinc and Manganese Superoxide Dismutases in Human Tissues
- P-66 Effects of Tamoxlfen Treatment on the Uterus and Ovary In Rats.(Proceedings of the 27th Annual Meeting)
- Expression of Prostatic Glutathione-Peroxidase (GSH-PO) in The Rat Treated With A Combination of Testosterone and 17β-Estradiol
- Amplification of Immunostaining Intensity by the Peroxidase-Antiperoxidase, Avidin-Biotin-Peroxidase Complex or Catalyzed Signal Amplification Method Gives Erroneous Antigen Content in Sections
- Changes in the Density of Cytochrome P-450 2B1/2 Molecules in the Membrane of Endoplasmic Reticulum in Perivenular, Midzonal and Periportal Hepatocytes of Rats after Administration of Phenobarbital
- B-32 Effect of rifampicin on carbon tetrachloride-induced DNA fragmentation in hepatocytes of mice
- Clinical Significance of Hepatocyte Growth Factor and Its Specific Receptor c-Met Expression in Colorectal Cancer Progression
- Osteopontin Expression May Be Induced by c-Src in Papillary Thyroid Carcinoma
- Osteopontin Expression in Papillary Thyroid Carcinoma
- Clinicopathological Factors Influencing the Apparent Diffusion Coefficients Obtained by Diffusion-weighted Magnetic Resonance Imaging in Patients with Colorectal Cancer
- Angiogenic factors in normal endometrium and endometrial adenocarcinoma
- Molecular biological approaches to neurological disorders including knockout and transgenic mouse models
- Immunolocalization of Androgen Receptor(AR)and Steroid 5 Alpha-Reductase Type II(5 Alpha-Reductase Type II)in Canine Prostate : -Effect of Antiandrogen, Chlormadinone Acetate(CMA)-
- Histopathological and Immunohistochemical Studies of the Effect of Antiandrogen, Chlormadinone Acetate (CMA), on Canine Spontaneous Benign Prostatic Hyperplasia (BPH)
- Expression of Glutathione-Peroxidase (GSH-PO) in the Rat Ventral Prostate : Effect of castration and administration of testosterone
- Immunolocalization of Glutathione-Peroxidase (GSH-PO) and Bcl-2 in the Rat Ventral Prostate : Effects of Castration and Administration of Testosterone
- Immunolocalization of Glutathione-Peroxidase (GSH-PO) in the Rat Ventral Prostate : Effects of Castration and Administration of Testosterone
- Immunolocalization of Glutathione-peroxidase and Androgen Receptors in the Rat Dorsolateral Prostate
- Immunohistochemical Localization of Tubulin and Actin in Rat Prostate
- Effects of Testosterone, and Testosterone Plus Estrogen, in the Castrated Rat Ventral Prostate : Histopathological and Immunocytochemical Studies
- Apoptosis in metastatic carcinoma of the central nervous system
- Activation of the Non-receptor Tyrosine Kinase cSrc in Macrophage-rich Atherosclerotic Plaques of Human Carotid Arteries
- Antivascular effects of TZT-1027 (Soblidotin) on murine Colon26 adenocarcinoma
- Glyoxal inactivates glutamate transporter-1 in cultured rat astrocytes
- Pathological and immunohistochemical findings of an autopsy case of adult moyamoya disease
- The Distribution of Pur Alpha Protein in Rat Tissues, and Its Intracellular Location
- Pur α Protein Implicated in Dendritic RNA Transport Interacts with Ribosomes in Neurosal Cytoplasm
- A-40 Retinal opsin mRNA in situ hybridization in the monkey retina.
- Immunohistochemical Detection of Retinal Cones in Monkey Retina : Light and Electron Microscopic Study
- Morphological Aspects of Superoxide Dismutase-1 Mutation in Amyotrophic Lateral Sclerosis and its Transgenic Mouse Model (Symposium VIIHistochemistry for Neuroscience Research)
- 22B-09-3 Paclitaxel-induced neurotoxicity depends on the treatment schedule in mice.
- Histopathological and Immunocytochemical Studies of Chlormadinone Acetate on the Rat Prostate
- Immunohistochemistry of the Canine Prostate
- Histopathological Study of Female Beagle Dogs for Four Year Treatment with Subcutaneous Implantation of Chlormadinone Acetate (CMA)
- TZT-1027, an Antimicrotubule Agent, Attacks Tumor Vasculature and Induces Tumor Cell Death
- Effect of Antiandrogen, Chlormadinone Acetate (CMA), in Canine Spontaneous Benign Prostatic Hyperplasia (BPH)
- Histopathological Studies of Subcutaneous Implantation of Chlormadinone Acetate (CMA) for Preventing Estrus in Queens
- Induction of Apoptosis in Mice with B16 Melanoma by Treatment with the Antimicrotubule Agent TZT-1027
- Histopathological Study of the Effect of Antiandrogen, Chlormadinone Acetate (CMA), on Canine Spontaneous Benign Prostatic Hyperplasia (BPH)
- Immunohistochemical Studies in Canine Prostatic Hyperplasia : Effect of Antiandrogen
- Ultrastructural Study in Canine Prostatic Hyperplasia : Effect of Antiandrogen
- Immunolocalization of Androgen Receptor in Canine Prostatic Hyperplasia : Effect of Antiandrogen
- Antitumor Activity of TZT-1027, a Novel Dolastatin 10 Derivative
- Comparison of inhibitory effects of warfarin on γ-carboxylation between bone and liver in rats
- Effects of Vitamin K_2 (Menatetrenone) on Calcium Balance in Ovariectomized Rats
- Inhibitory Effect of Vitamin K_2 (Menatetrenone) on Bone Resorption in Ovariectomized Rats : A Histomorphometric and Dual Energy X-Ray Absorptiometric Study
- REGULATION OF PROSTATIC GLUTATHIONE-PEROXIDASE (GSH-PO) IN RATS TREATED WITH A COMBINATION OF TESTOSTERONE AND 17β-ESTRADIOL
- Immunoreactive Pit-1 Protein in Hyperplastic Pars Intermedia Induced by Calcitonin of the Rat Pituitary Gland
- Immunohistochemical Studies of Early Changes of Pituitary Glands Induced by Synthetic Salmon Calcitonin (sCT) jn Sprague-Dawley Rats : Experimental Models for the Human Alpha-Subunit-Producing Pituitary Adenomas
- Free Vibration Analysis of Shells of Revolution Considering the Fluid-Structure Interaction
- Fukutin expression in mouse non-muscle somatic organs : its relationship to the hypoglycosylation of α-dystroglycan in Fukuyama-type congenital muscular dystrophy
- Immunohistochemical Studies of the Effect of Chlormadinone Acetate (CMA) on Prostatic Hyperplasia
- P-62 Histopathological and Immunohistochemical Studies of the Effect of Chlormadinone Acetate (CMA), on Canine Spontaneous Benign Prostatic Hyperplasia (BPH).(Proceedings of the 27th Annual Meeting)
- ATROPHIC EFFECTS OF ANTIANDROGEN, CHLORMADINONE ACETATE(CMA)ON DOG PROSTATE WITH SPONTANEOUS BENIGN PROSTATIC HYPERPLASIA
- A SIGNIFICANT RELATIONSHIP BETWEEN GLUTATHIONE-PEROXIDASH (GSH-PC) LOCALIZATION AND BIOLOGICAL ACTION OF TESTOSTERONE IN RAT VENTRAL PROSTATE
- Intralobular expression of CYP2B1/2 in livers of rats after single or repetitive injections of phenobarbital
- Application of chemiluminescent reactions into quantitative immunohistochemistry
- I-B-11 Localization of Monocarboxylate Transporters MCT1 and MCT4 in Rat Skeletal Muscle (2^ report)(THE 45TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- B-16 A morphological investigation of the relationship between arachnoid membrane and the core of arachnoid granulations by 5^1-nucleotidase histochemistry
- Characterization of the Interaction of TZT-1027, a Potent Antitumor Agent,with Tubulin
- Chronological Expression and its Significance of c-jun and c-fos mRNA in Rat Brain
- Argyrophilic meshwork structures in the cerebral cortex of patients with progressive supranuclear palsy
- Plaque-like structures in the cerebral cortex of corticobasal degeneration : A histopathologic marker?
- New insights into the pathogenesis of spinal muscular atrophy
- Serum Integrin β1 Levels as a Prognostic Marker in Metastatic Colorectal Cancer
- Correlation between Prostatic Atrophy and Apoptosis in the Canine Spontaneous Benign Prostatic Hyperplasia (BPH) Following Chlormadinone Acetate (CMA) Administration
- Histopathological and Immunohistochemical Studies in Female Beagle Dogs during Four Years Treatment with Implantation of Chlormadinone Acetate (CMA)
- Bovine serum albumin coordinated iron-sulfur cluster as a hydrogenase model.