Effect of Antiandrogen, Chlormadinone Acetate (CMA), in Canine Spontaneous Benign Prostatic Hyperplasia (BPH)
スポンサーリンク
概要
- 論文の詳細を見る
The effect of synthetic steroidal antiandrogen, chlormadinone acetate (CMA), on spontaneous benign prostatic hyperplasia (BPH) in dogs was investigated. Male beagle dogs (5-8 years old) were divided into three experimental groups. Group 1 consisted of untreated controls. Groups 2 and 3 received CMA 0.03, and 0.1 mg/kg/day, p. o., respectively, for 6 months. In group 1, glandular hyperplasia of the prostate was clearly detected. In groups 2 and 3, CMA produced marked atrophy of the glandular epithelium. In addition, a histopathological study showed that CMA medication for 6 months exerted no effect on the testes and adrenals or on immunoreactive LH- and ACTH- cells of the anterior pituitary glands. Therefore, it is suggested that CMA (0.03 and 0.1 mg/kg) causes regression of spontaneous canine BPH without any histopathological effects on the testes, adrenals or anterior pituitary LH- and ACTH-cells.
- 東海大学の論文
著者
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Mikami T
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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Tagawa Masashi
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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NAKAYAMA Takaharu
Safety Res. Dept., Teikoku Hormone Mfg. Co., Ltd., of Kanagawa Pref.
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MURAKOSHI Masanori
Safety Research Department, Teikoku Hormone Mfg. Co., Ltd.
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Ikeda Rie
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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Murakoshi M
(present Address)products Strategy Dcpartment Pharma Business Strategy Division Teikoku Hormone Mfg.
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Murakoshi Masanori
Safety Res. Dept. Teikoku Hormone Mfg Co. Ltd.
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Mikami T
Department Of Drug Safety Research Eisai Kawashima Research Laboratories Eisai Co. Ltd.
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Nakayama Takaharu
Medicinal Research Department Teikoku Hormone Mfg. Co. Ltd.
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Nakayama Takaharu
Safety Res. Dept. Teikoku Hormone Mfg. Co. Ltd. Of Kanagawa Pref.
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IKADA Rie
Safety Research Department, Teikoku Hormone Mfg. Co., Ltd.
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Natsume Tsugitaka
Teikoku Hormone Mig. Co. Ltd.
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Inada Rie
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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Ikada Rie
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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Nakayama T
Aska Pharmaceutical Co. Ltd. Research & Development Division
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