STUDIES ON EXPERIMENTAL IODINE ALLERGY : 3. LOW MOLECULAR WEIGHT ELICITOGENIC ANTIGENS OF IODINE ALLERGY
スポンサーリンク
概要
- 論文の詳細を見る
We hypothesize that iodine allergy is an immune response to iodinated self proteins produced in vivo from various iodine-containing chemicals. Since an antigenic determinant of experimental iodine allergy is diiodotyrosine (DIT), we designed low molecular weight DIT derivatives having provocative antigenicity without sensitizing immunogenicity. Tetraiododityrosine and hexaiodotrityrosine provoked dose-dependent skin reactions in guinea pigs previously immunized with iodine. No guinea pigs immunized with hexaiodotrityrosine showed anaphylactic reaction by i. v. challenge with hexaiodotrityrosine and none of their antisera showed positive passive cutaneous anaphylaxis (PCA) reaction in guinea pigs, indicating the non-immunogenic nature of the compound. Erythrosine, one of the color additives having a structure common with DIT, was assessed for its immunological property. Enzyme-linked immunosorbent assay (ELISA) inhibition studies on erythrosine revealed that the inhibitory activity of erythrosine was stronger than that of DIT. Furthermore, erythrosine provoked a PCA reaction in animals sensitized with anti-iodine antisera. In conclusion, hexaiodotrityrosine is thought to be useful for skin testing of iodine allergy without any fear of sensitization to the allergen. Erythrosine was shown to provoke an experimental iodine allergy and, also, the relationships between the new concept of iodine allergy and features of clinical findings of adverse effects by iodocontrast media are discussed.
- 日本トキシコロジー学会の論文
- 2004-05-28
著者
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Sagami Fumio
第一三共安全性研究所
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Sagami Fumio
Drug Safety Research Laboratories Eisai Co. Ltd.
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Sagami Fumio
Subcommittee Of Non-clinical Evaluation Drug Evaluation Committee Japan Pharmaceutical Manufacturers
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Sagami Fumio
Department Of Drug Safety Research Eisai Kawashima Research Laboratories Eisai Co. Ltd.
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Okano K
Eisai Co. Ltd. Ibaraki Jpn
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Okano Kazuo
Exploratory Division Eisai Tsukuba Research Laboratories Eisai Co. Ltd.
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Okano Kazuo
Department Of Electrical System Engineering Polytechnic University
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Mikami T
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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Tagawa Masashi
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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SUGIHARA Yoshiki
Department of Drug Safety Research, Eisai Tsukuba Research Laboratories, Eisai Co., Ltd.
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SHIONOYA Hiroshi
Department of Drug Safety Research, Eisai Kawashima Research Laboratories, Eisai Co., Ltd.
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MIKAMI Takashi
Department of Drug Safety Research, Eisai Kawashima Research Laboratories, Eisai Co., Ltd.
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KATAYAMA Kouichi
Exploratory Division, Eisai Tsukuba Research Laboratories, Eisai Co., Ltd.
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Mikami T
Department Of Drug Safety Research Eisai Kawashima Research Laboratories Eisai Co. Ltd.
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Sagami Fumio
Department Of Developmental Safety Assessment Research Eisai Co. Ltd.
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Sugihara Yoshiki
Department Of Drug Safety Research Eisai Tsukuba Research Laboratories Eisai Co. Ltd.
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Katayama Kouichi
Exploratory Division Eisai Tsukuba Research Laboratories Eisai Co. Ltd.
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Mikami Takashi
Department Of Applied Chemistry Graduate School Of Advanced Science And Engineering Waseda Universit
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Shionoya H
Department Of Drug Safety Research Eisai Kawashima Research Laboratories Eisai Co. Ltd.
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