STUDIES ON EXPERIMENTAL IODINE ALLERGY : 1. ANTIGEN RECOGNITION OF GUINEA PIG ANTI-IODINE ANTIBODY
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概要
- 論文の詳細を見る
It has generally been thought that iodine allergy is cross-sensitive to various iodine-containing chemicals. However, this concept seems to deviate from the immunological principle that immune recognition is specific. To solve this contradiction, we hypothesize that iodine allergy is an immunological reaction to iodinated autologous proteins produced in vivo by iodination reaction from various iodine-containing chemicals. Antisera to iodine were obtained from guinea pigs immunized subcutaneously with iodine-potassium iodide solution emulsified in complete Freund's adjuvant (CFA). The specificity of guinea pig anti-iodine antiserum was determined by enzyme-linked immunosorbent assay (ELISA) inhibition experiments using microplates coated with iodinated guinea pig serum albumin (I-GSA). Antibody activities were inhibited by I-GSA, diiodo-L-tyrosine, and thyroxine, but not by potassium iodide, monoiodo-L-tyrosine, 3, 5, 3'-triiodothyronine, monoiodo-L-histidine, or diiodo-L-histidine, or by ionic or non-ionic iodinated contrast media. The results that antigen recognition of anti-iodine antibody is specific to iodinated protein support our hypothesis. While protein iodination usually takes place both at histidine residues as well as at tyrosine residues, only iodinated tyrosine acted as an antigenic determinant and no antibody activities to iodinated histidine were detected in our experimental iodine allergy model.
- 日本トキシコロジー学会の論文
- 2004-05-28
著者
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Sagami Fumio
第一三共安全性研究所
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Sagami Fumio
Drug Safety Research Laboratories Eisai Co. Ltd.
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Sagami Fumio
Subcommittee Of Non-clinical Evaluation Drug Evaluation Committee Japan Pharmaceutical Manufacturers
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Sagami Fumio
Department Of Drug Safety Research Eisai Kawashima Research Laboratories Eisai Co. Ltd.
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Okano K
Eisai Co. Ltd. Ibaraki Jpn
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Okano Kazuo
Exploratory Division Eisai Tsukuba Research Laboratories Eisai Co. Ltd.
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Okano Kazuo
Department Of Electrical System Engineering Polytechnic University
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Mikami T
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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Tagawa Masashi
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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SUGIHARA Yoshiki
Department of Drug Safety Research, Eisai Tsukuba Research Laboratories, Eisai Co., Ltd.
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SHIONOYA Hiroshi
Department of Drug Safety Research, Eisai Kawashima Research Laboratories, Eisai Co., Ltd.
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MIKAMI Takashi
Department of Drug Safety Research, Eisai Kawashima Research Laboratories, Eisai Co., Ltd.
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KATAYAMA Kouichi
Exploratory Division, Eisai Tsukuba Research Laboratories, Eisai Co., Ltd.
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Mikami T
Department Of Drug Safety Research Eisai Kawashima Research Laboratories Eisai Co. Ltd.
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Sagami Fumio
Department Of Developmental Safety Assessment Research Eisai Co. Ltd.
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Sugihara Yoshiki
Department Of Drug Safety Research Eisai Tsukuba Research Laboratories Eisai Co. Ltd.
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Katayama Kouichi
Exploratory Division Eisai Tsukuba Research Laboratories Eisai Co. Ltd.
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Mikami Takashi
Department Of Applied Chemistry Graduate School Of Advanced Science And Engineering Waseda Universit
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Shionoya H
Department Of Drug Safety Research Eisai Kawashima Research Laboratories Eisai Co. Ltd.
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