Histopathological Study of Female Beagle Dogs for Four Year Treatment with Subcutaneous Implantation of Chlormadinone Acetate (CMA)
スポンサーリンク
概要
- 論文の詳細を見る
The histopathological changes related to chlormadinone acetate (CMA) implantation were examined using female beagle dogs given 10mg/kg for four years. All control animals showed sign of estrus during the experiment, with periods of anestrus of normal duration. In contrast, estrus was completely inhibited in the CMA-implanted animals. Histopathologically, uterine sections from the CMA-implanted animals showed cystic glandular hyperplasia, but no histologic evidence of endometritis, myometritis, and pyometra was found. In the ovaries of the CMA-implanted animals, developing ovarian follicles were observed but no mature follicles were noted in addition to an absence of corpus luteum. No remarkable changes were observed in the liver, adrenal, mammary gland, gallbladder and implanted site. Furthermore, the intensity of staining and number and size of ACTH-and LH-positive cells in the pituitary sections of CMA-implanted animals were not different from control animals. It was concluded, therefore, that subcutaneous implantation of CMA is a potential drug-delivery system for reducing changes due to antigonadotropic and glucocorticoid-like activities and characteristic histopathological changes in the uterus due to progestagenic activity.
- 東海大学の論文
著者
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Mikami T
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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Tagawa Masashi
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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NAKAYAMA Takaharu
Safety Res. Dept., Teikoku Hormone Mfg. Co., Ltd., of Kanagawa Pref.
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MURAKOSHI Masanori
Safety Research Department, Teikoku Hormone Mfg. Co., Ltd.
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Ikeda Rie
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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Murakoshi M
(present Address)products Strategy Dcpartment Pharma Business Strategy Division Teikoku Hormone Mfg.
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Murakoshi Masanori
Safety Res. Dept. Teikoku Hormone Mfg Co. Ltd.
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Mikami T
Department Of Drug Safety Research Eisai Kawashima Research Laboratories Eisai Co. Ltd.
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Nakayama Takaharu
Medicinal Research Department Teikoku Hormone Mfg. Co. Ltd.
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Nakayama Takaharu
Safety Res. Dept. Teikoku Hormone Mfg. Co. Ltd. Of Kanagawa Pref.
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IWASAKA Toshio
Safety Research Department, Teikoku Hormone Mfg. Co., Ltd.
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Iwasaka Toshio
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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Natsume Tsugitaka
Teikoku Hormone Mig. Co. Ltd.
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Inada Rie
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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Ikada Rie
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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Nakayama T
Aska Pharmaceutical Co. Ltd. Research & Development Division
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