Effects of the New Anti-Ulcer Agent KB-5492 on Experimental Gastric Mucosal Lesions and Gastric Mucosal Defensive Factors, as Compared to Those of Teprenone and Cimetidine.
スポンサーリンク
概要
- 論文の詳細を見る
Effects of KB-5492, a new anti-ulcer agent, on various experimental gastric mucosal lesions and mucosal defensive factors in rats were compared with those of teprenone and cimetidine. KB-5492 administered orally at 12.5-200 mg/kg inhibited water-immersion stress- and indomethacin-induced gastric mucosal lesions in a dose-dependent manner with ED<SUB>50</SUB> values of 46 and 27 mg/kg, respectively, indicating that KB-5492 was more potent than teprenone but less potent than cimetidine. KB-5492, administered orally at 12.5-100 mg/kg, also inhibited ethanol-induced gastric mucosal lesions in a dose-dependent manner with an ED<SUB>50</SUB> of 23 mg/kg, so KB-5492 was 3 times more potent than teprenone, whereas cimetidine produced no obvious inhibition. In addition, KB-5492, administered orally at 25 and 50 mg/kg twice daily for 10 consecutive days, significantly accelerated the healing of acetic acid-induced gastric ulcers more potently than teprenone and cimetidine. KB-5492 at anti-ulcer doses significantly increased gastric mucosal blood flow in normal anesthetized rats and inhibited the reduction of gastric mucosal hexosamine content induced by aspirin, but did not affect gastric acid secretion in pylorus-ligated rats. These results indicate that KB-5492 has potent and broad anti-ulcer properties, which are probably exerted by its enhancement of gastric mucosal defensive factors through increasing gastric mucosal blood flow and/or retaining gastric mucus, and not by its inhibition of gastric acid secretion.
- 公益社団法人 日本薬理学会の論文
著者
-
Morimoto Yasuo
Department Of Chemical Engineering Osaka Prefecture University
-
Sukamoto Takayuki
Department Of Pharmacology Jichi Medical School
-
Oshima Shinya
Department of Pharmacology, New Drug Research Laboratories, Kanebo Ltd.
-
SHIMOHARA Koichi
Department of Applied Pharmacology, Kyoto Pharmaceutical University
-
Shimohara Koichi
Department of Pharmacology, New Drug Research Laboratories, Kanebo Ltd.
関連論文
- Differential Expression of EC-SOD, Mn-SOD and CuZn-SOD in Rat Lung Exposed to Crystalline Silica
- Effect of Particle Size of Intratracheally Instilled Crystalline Silica on Pulmonary Inflammation
- Expression of Heme Oxygenase-1 in the Lungs of Rats Exposed to Crystalline Silica
- Clearance of Deposited Silicon Carbide Whisker from Rat Lungs Inhaled during a 4-Week Exposure
- Clearance of Inhaled Potassium Octatitanate Whisker from Rat Lungs
- Predisposing Factors of Sleep-Disordered Breathing in Japanese Male Workers
- The Usefulness of Sleep Apnea Syndrome Screening using a Portable Pulse Oximeter in the Workplace
- Synthesis of hollow silica microparticles from bacterial templates
- Anomalous Shift of ESR Lines in Two Dimensional Antiferromagnet Cu(HCOO)_24H_2O
- Magnetic Resonance in NiBr_2 near the Critical Field
- Inhibitory Effect of Lomerizine, a Diphenylpiperazine Ca^-Channel Blocker, on Ba^ Current through Voltage-Gated Ca^ Channels in PC12 Cells
- EFFECTS OF β-ADRENERGIC BLOCKING DRUGS IN HYPERTENSIVE RATS
- Effects of KB-5492, a New Anti-Ulcer Agent, on Ethanol- and Acidified Aspirin-Induced Gastric Mucosal Damage In Vivo and In Vitro.
- Effect of KB-2796, a New Diphenylpiperazine Ca2+ Antagonist, on Glutamate-Induced Neurotoxicity in Rat Hippocampal Primary Cell Cultures.
- Effects of KB-2796, a New Diphenylpiperazine Calcium Antagonist, on Renal Hemodynamics and Urine Formation in Anesthetized Dogs.
- Effects of the New Anti-Ulcer Agent KB-5492 on Experimental Gastric Mucosal Lesions and Gastric Mucosal Defensive Factors, as Compared to Those of Teprenone and Cimetidine.
- Effects of KB-5492, 1-(3,4,5-trimethoxybenzyl)-4-((4-methoxyphenyl)oxycarbonylmethyl)piperazine monofumarate monohydrate, on gastric lesions and gastric secration in rats.
- 4-Methoxyphenyl 4-(3,4,5-Trimethoxybenzyl)-1-Piperazineacetate Monofumarate Monohydrate (KB-5492), a New Anti-Ulcer Agent with a Selective Affinity for the Sigma Receptor, Prevents Cysteamine-Induced Duodenal Ulcers in Rats by a Mechanism Different from T