Inhibitory Effect of Lomerizine, a Diphenylpiperazine Ca^<2+>-Channel Blocker, on Ba^<2+> Current through Voltage-Gated Ca^<2+> Channels in PC12 Cells

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概要

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• We investigated the effect of lomerizine, an anti-migraine drug, on the Ba<SUP>2+</SUP> current through voltage-gated Ca<SUP>2+</SUP> channels in rat pheochromocytoma (PC12) cells using a whole-cell voltage-clamp technique. Lomerizine inhibited the Ba<SUP>2+</SUP> current with an IC<SUB>50</SUB> value of 1.9 μM. Lomerizine and nicardipine were > 4 times more potent than flunarizine, diltiazem, verapamil and dimetotiazine. The time course of inactivation induced by lomerizine was similar to that induced by nicardipine and flunarizine. These data indicate that lomerizine may inhibit the Ca<SUP>2+</SUP> channel in a similar manner to nicardipine and flunarizine, and its potency is almost equal to that of nicardipine.

• 社団法人 日本薬理学会の論文
• 1997-10-01

著者

• Hara Hideaki

  参天製薬

• Hara Hideaki

  Department Of Biofunctional Evaluation Molecular Pharmacology Gifu Pharmaceutical University

• WATANO Tomokazu

  Department of Pharmacology, Fukushima Medical University, School of Medicine

• Watano Tomokazu

  Department Of Pharmacology Fukushima Medical University School Of Medicine

• Sukamoto Takayuki

  Department Of Pharmacology Jichi Medical School

• Hara Hideaki

  Department Of Pharmacology New Drug R & D Laboratory Kanebo Ltd

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