Effects of Anions on ATP-Induced[Ca^<2+>]_i Increase in NG108-15 Cells
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概要
- 論文の詳細を見る
We investigated the effects of anions on different P2 receptors by measuring ATP-induced increase in intracellular Ca2+ concentration ([Ca2+]i) in fura-2-loaded NG108-15 and PC12 cells. In NG108-15 cells, ATP at 100 μM and 1 mM induced a transient and a sustained [Ca2+]i increase, respectively. The former, but not the latter, was inhibited by U-73122, indicating that the former was via the P2Y2 receptor and the latter via the P2X7 receptor. When external Cl− was replaced by other anions, the [Ca2+]i increase mediated by the P2Y2 receptor was not changed, but that mediated by the P2X7 receptor varied in the order of aspartate− > methanesulfonate− > Cl− > Br ≥ I−. In PC12 cells, transient [Ca2+]i increases mediated by the P2Y2 and P2X2 receptors were not affected by various anions. These results suggest that modulation by anions s unique to the P2X7 receptor and does not occur in P2Y2 and P2X2 receptors. This may be because the mechanism of ATP binding to the P2X7 receptor may be different than that to other P2 receptors.
- 社団法人 日本薬理学会の論文
- 2002-07-01
著者
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Kimura Junko
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Toho University
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Ogawa Kohei
Department of Chemical Engineering, Tokyo Institute of Technology
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Ogawa Kohei
Department Of Chemical Engineering Graduate School Of Science And Engineering Tokyo Institute Of Tec
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Kimura J
Dep. Of Pharmacology School Of Medicine Fukushima Medical Univ. Jpn
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Ogawa Kohei
Department Of Pharmacology Fukushima Medical University School Of Medicine
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Kimura J
Department Of Pharmacology Fukushima Medical University School Of Medicine
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WATANO Tomokazu
Department of Pharmacology, Fukushima Medical University, School of Medicine
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MATSUOKA Isao
Department of Pharmacology, Fukushima Medical University, School of Medicine
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Matsuoka Isao
Department Of Pharmacology Fukushima Medical College
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Watano Tomokazu
Department Of Pharmacology Fukushima Medical University School Of Medicine
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Matsuoka Isao
Department Of Anesthesiology Ilikai Medical Inc Kakizoe Hospital
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Matsuoka Isao
Dep. Of Pharmacology Fukushima Medical Univ. School Of Medicine Jpn
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