ATP-and Adenosine-Mediated Signaling in the Central Nervous System : Adenosine Receptor Activation by ATP Through Rapid and Localized Generation of Adenosine by Ecto-nucleotidases
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概要
- 論文の詳細を見る
Extracellular ATP is now recognized as a neurotransmitter or neuromodilator in the nervous system, producing diverse physiological effects by activating multiple P2 receptors. Although P2-receptor signaling is terminated by hydrolysis of ATP by the ecto-nucleotidase cascade, such a metabolic step leads to adenosine generation, thereby initiating adenosine (P1)-receptor activation. Because most cells and tissues co-express P1 and P2 receptors, ecto-nucleotidase on target tissues, especially enzymes catalyzing adenosine formation, are determinants of the cellular response to ATP. Ecto-5-nucleotidase (E-5-NT) has been considered to play a principal role in conversion of AMP to adenosine. In addition to E-5-NT, we have recently demonstrated that ecto-alkaline phosphatase is also involved in ATP-induced P1-receptor activation through a rapid and localized adenosine production on the membrane surface. In this minireview, we describe the pharmacological profile of ecto-nucleotidase-dependent P1-receptor activation by ATP and molecular bases of preferential delivery of metabolically generated adenosine to P1 receptors. Several lines of evidence suggest that the close association between ecto-nucleotidases and P1 receptors may constitute a functional receptor for extracellular ATP, and some physiological responses to ATP would occur through this mechanism.
- 社団法人 日本薬理学会の論文
- 2004-02-01
著者
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MATSUOKA Isao
Department of Pharmacology, Fukushima Medical University, School of Medicine
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Matsuoka Isao
Department Of Pharmacology Fukushima Medical University School Of Medicine
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Matsuoka Isao
Department Of Pharmacology Fukushima Medical College
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OHKUBO Satoko
Department of Pharmacology, Fukushima Medical College
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Ohkubo Satoko
Department Of Cellular Signaling Graduate School Of Pharmaceutical Sciences
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Matsuoka Isao
Department Of Anesthesiology Ilikai Medical Inc Kakizoe Hospital
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