Lysophosphatidylcholine Increases Na^+/Ca^<2+> Exchanger Expression via RhoB-Geranylgeranylation in H9c2 Cells
スポンサーリンク
概要
- 論文の詳細を見る
The expression levels of the Na+/Ca2+ exchanger type 1 (NCX1) change under various cardiac pathophysiological conditions, but the mechanism is unknown. We previously demonstrated that lysophosphatidylcholine (LPC) increased NCX1 expression by activating RhoB in H9c2 cardiomyoblasts. Conversely, fluvastatin (Flv), a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, decreased NCX1 mRNA and protein expression by inhibiting RhoB. RhoB can be isoprenylated by either geranylgeranylpyrophosphate (GGPP) or farnesylpyrophosphate (FPP). Here we investigated which of GGPP or FPP is involved in the NCX1-increasing effect of LPC. When LPC was added with GGPP to the Flv-treated H9c2 cells, NCX1 mRNA was increased to a level significantly higher than that in the control cells. Only GGPP, but not FPP, allowed LPC to increase NCX1 mRNA in the presence of Flv. Furthermore, geranylgeranyltransferase 1 inhibitor (GGTI), but not farnesyltransferase inhibitor (FTI), inhibited the LPC-induced NCX1 mRNA increase. We conclude that geranylgeranylation, but not farnesylation, of RhoB mediates LPC-induced NCX1 mRNA increase in H9c2 cells.
- 社団法人 日本薬理学会の論文
- 2009-04-20
著者
-
Kimura Junko
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Toho University
-
Iwamoto Takahiro
Department of Pharmacology, Fukuoka University
-
Sakamoto Kazuho
Department of Pharmacology, School of Medicine, Fukushima Medical University, Japan
-
Kimura J
Dep. Of Pharmacology School Of Medicine Fukushima Medical Univ. Jpn
-
Iwamoto Takahiro
Department Of Pharmacology Fukuoka University School Of Medicine
-
Iwamoto Takahiro
Department Of Medical Engineering And Cardiology Institute Of Development Aging And Cancer Tohoku Un
-
Kimura J
Department Of Pharmacology Fukushima Medical University School Of Medicine
-
MATSUOKA Isao
Department of Pharmacology, Fukushima Medical University, School of Medicine
-
Matsuoka Isao
Department Of Pharmacology Fukushima Medical College
-
Maeda Sachiko
Department Of Pharmacology Fukushima Medical University School Of Medicine
-
Maeda Sachiko
Department Of Biology Faculty Of Science Kobe University
-
Sakamoto Kazuho
Department Of Molecular And Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya
-
Sakamoto Kazuho
Department Of Pharmacology School Of Medicine Fukushima Medical University
-
Matsuoka Isao
Department Of Anesthesiology Ilikai Medical Inc Kakizoe Hospital
関連論文
- Development of a Quinazoline-Based Chelating Ligand for Zinc Ion and Its Application to Validation of a Zinc-Ion-Coordinated Compound
- PE-077 Blocking Effect of SN-6, a Novel Benzyloxyphenyl Derivative, on Na^+/Ca^ Exchange Current in Single Guinea-pig Cardiac Ventricular Myocytes(Cardiovascular pharmacology, basic/clinical-3 (H) PE13,Poster Session (English),The 70th Anniversary Ann
- Mechanism of Statin-Induced Contractile Dysfunction in Rat Cultured Skeletal Myofibers
- Genotypic Effect of ABCG1 Gene Promoter -257T>G Polymorphism on Coronary Artery Disease Severity in Japanese Men
- Involvement of Na^+-Ca^ Exchanger in Forskolin-induced Vasorelaxation in Mouse Thoracic Aorta : Evaluation Using NCX Transgenic Mouse Model(Vascular Smooth Muscle 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Microsomal Aldehyde Oxygenase (MALDO) for Tolualdehydes, Active Metabolites of Xylenes, in the Mouse Liver and Lung
- Inhibitory Action of Troglitazone, an Insulin-Sensitizing Agent, on the Calcium Current in Cardiac Ventricular Cells of Guinea Pig
- Increased high frequency components of QRS complex detected by wavelet analysis predicts vulnerability to ventricular tachycardia in hypertensive rats
- Comprehensive Analyses of Arrhythmogenic Substrates and Vulnerability to Ventricular Tachycardia in Left Ventricular Hypertrophy in Salt-Sensitive Hypertensive Rats
- Pharmacological Significance of the Blocking Action of the Intravenous General Anesthetic Propofol on the Slow Component of Cardiac Delayed Rectifier K^+ Current
- Anomalous Susceptibility of UPd_2Al_3 near the Upper Critical Field
- Inhibitory Effects of Isoliquiritigenin and Licorice Extract on Voltage-Dependent K^+ Currents in H9c2 Cells
- PE-405 Effect of Pioglitazone on Lipid Profiles as Assessed by Analytical Capillary Isotachophores is in Patients with Type 2 Diabetes(Diabetes/Obesity/Metabolic syndrome(07)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Ci
- Forefront of Na^+/Ca^ Exchanger Studies : Physiology and Molecular Biology of Monovalent Cation Sensitivities in Na^+/Ca^ Exchangers
- Topics on the Na^+/Ca^ Exchanger : Pharmacological Characterization of Na^+/Ca^ Exchanger Inhibitors
- Effects of Anions on ATP-Induced[Ca^]_i Increase in NG108-15 Cells
- Inhibitory Effects of Metals on ATP-Induced Current Through P2X_7 Receptor in NG108-15 Cells
- Characteristics of ATP-Induced Current Through P2X_7 Receptor in NG108-15 Cells : Unique Antagonist Sensitivity and Lack of Pore Formation
- Blocking Effect of Bepridil on Na^+/Ca^ Exchange Current in Guinea Pig Cardiac Ventricular Myocytes
- Hepatocyte Growth Factor (HGF) and C-Met/HGF Receptor Expression in Human and Rat Vascular Tissues with Chronic Limb Ischemia
- Efficacy of antibiotics against influenza-like illness in an influenza epidemic
- Lysophosphatidylcholine Increases Na^+/Ca^ Exchanger Expression via RhoB-Geranylgeranylation in H9c2 Cells
- Na^+-Ca^ Exchanger Expression and Its Modulation(Functional Changes Induced by Long-Term Stimulation of Nicotinic Acetylcholine Receptors)
- Inhibitory Effect of Thiopental on Ultra-rapid Delayed Rectifier K^+ Current in H9c2 Cells
- Effects of a Novel Cardioprotective Drug, JTV-519, on Membrane Currents of Guinea Pig Ventricular Myocytes
- Molecular Phylogeny of the Suborder Leucodontineae (Musci;Leucodontales) Inferred from rbcL Sequence Data
- Effects of YT : 146 [2 : (1 : Octyny1) Adenosine], an Adenosine A_ Receptor Agonist, on cAMP Production and Noradrenaline Release in PC12 Cells
- Correlation Between Adenine Nucleotide-Induced Cyclic AMP Elevation and Extracellular Adenosine Formation in NG108-15 Cells
- ATP-and Adenosine-Mediated Signaling in the Central Nervous System : Adenosine Receptor Activation by ATP Through Rapid and Localized Generation of Adenosine by Ecto-nucleotidases
- Role of Na^+/Ca^2+ Exchanger Type1 (NCX1) in the Angiogenesis Induced by Lipo-PGE_1 in Murine Hindlimb Ischemia Model
- OE-089 Development of IVUS Attenuation Imaging and Comparison with Multiple Parametric Imagings(Intravascular endoscopy/Intravascular ultrasound-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Moment-based texture segmentation of luminal contour in intravascular ultrasound images
- Selective Up-regulation of P2X_4-Receptor Gene Expression by Interferon-γ in Vascular Endothelial Cells
- Acidic Preconditioning Inhibits Na^+/H^+ and Na^+/Ca^ Exchanger Interaction via PKCε in Guinea-Pig Ventricular Myocytes
- Mechanism of Na^+/Ca^ Exchanger Activation by Hydrogen Peroxide in Guinea-Pig Ventricular Myocytes
- Chronic Administration of Amiodarone Does Not Affect Na^+/Ca^ Exchange Current in Guinea Pig Cardiac Ventricular Myocytes
- A Novel Opener of Large-Conductance Ca^-Activated K^+ (BK) Channel Reduces Ischemic Injury in Rat Cardiac Myocytes by Activating Mitochondrial K_ Channel
- Involvement of Na+/Ca2+ Exchanger in Pentylenetetrazol-Induced Convulsion by Use of Na+/Ca2+ Exchanger Knockout Mice
- PJ-543 Hydrogen Peroxide Activates Na+/Ca2+ Exchanger through Two Different Signaling Pathways in Guinea-Pig Ventricular Myocytes(Myocardial Ischemia-Reperfusion, Basic and Clinical 3 (M) : PJ91)(Poster Session (Japanese))
- The Role of Sodium, Calcium, and Magnesium Transport in the Renal Distal Tubule
- Role of Cl^- Channels and Transporters in Cardiac Cell volume Homeostasis
- Endoplasmic Reticulum Is a Key Organella in Bradykinin-Triggered ATP Release From Cultured Smooth Muscle Cells
- Mechanisms Underlying the Activation of Large Conductance CA^-Activated K^+ Channels by Nordihydroguaiaretic Acid
- Forefront of Na^+/Ca^ Exchanger Studies : Molecular Pharmacology of Na^+/Ca^ Exchange Inhibitors
- Cardiovascular Na^+/Ca^ Exchanger : Pathophysiologic Roles and Therapeutic Potentials
- Inhibitory Effect of Azimilide on Na+/Ca2+ Exchange Current in Guinea-Pig Cardiac Myocytes
- Cellular Ca^ Dynamics in Urinary Bladder Smooth Muscle From Transgenic Mice Overexpressing Na^+-Ca^ Exchanger
- Effect of Sodium Intake on Urinary Renin Excretion in Rats
- RENAL INACTIVE KALLIKREIN AS THE POSSIBLE ORIGIN OF URINARY INACTIVE KALLIKREIN IN THE RAT
- CONVERSION OF LOW MOLECULAR WEIGHT RENIN INTO THE HIGH MOLECULAR WEIGHT FORM BY Cu^ IN THE RAT KIDNEY
- Report on the Women in Physiology Symposium in IUPS 2009
- Topics on the Na^+/Ca^ Exchanger : Role of Vascular NCX1 in Salt-Dependent Hypertension
- New Molecular Mechanisms for Cardiovascular Disease:Cardiac Hypertrophy and Cell-Volume Regulation
- Cellular Ca2+ Dynamics in Urinary Bladder Smooth Muscle From Transgenic Mice Overexpressing Na+-Ca2+ Exchanger
- Mechanism of Pulmonary Cytochrome P450 Inactivation by Tolualdehydes, Active Metabolites of Xylenes (Proceedings of the 22nd Symposium on Toxicology and Environmental Health)
- Metabolic Reaction of Tolualdehydes by Microsomal Aldehyde Oxygenase (MALDO) in Lung (Proceedings of the 19th Symposium on Toxicology and Environmental Health)
- Inactivation of Membrane Surface Ecto-5′-nucleotidase by Sodium Nitroprusside in C6 Glioma Cells
- Flexible Tack for Ventral Hernia Repair
- Muscarinic M2 receptors inhibit Ca^-activated K^+channel in rat bladder smooth muscle
- Forefront of Na^+/Ca^ Exchanger Studies : Stoichiometry of Cardiac Na^+/Ca^ Exchanger ; 3:1 or 4:1?
- Topics on the Na^+/Ca^ Exchanger : Preface
- Forefront of Na^+/Ca^ Exchanger Studies : Preface
- The beginning of the calcium transient in rat embryonic heart
- Inactivation of Membrane Surface Ecto-5'-nucleotidase by Sodium Nitroprusside in C6 Glioma Cells
- Mechanism of Statin-Induced Contractile Dysfunction in Rat Cultured Skeletal Myofibers
- Inhibitory Effect of Azimilide on Na+^/Ca^ Exchange Current in Guinea-Pig Cardiac Myocytes
- Forefront of Na+/Ca2+ Exchanger Studies: Stoichiometry of Cardiac Na+/Ca2+ Exchanger; 3:1 or 4:1?
- Topics on the Na+/Ca2+ Exchanger: Role of Vascular NCX1 in Salt-Dependent Hypertension
- Forefront of Na+/Ca2+ Exchanger Studies: Molecular Pharmacology of Na+/Ca2+ Exchange Inhibitors
- New Molecular Mechanisms for Cardiovascular Disease : Preface
- New Molecular Mechanisms for Cardiovascular Disease : Cardiac Hypertrophy and Cell-Volume Regulation
- Inhibitory Effects of Citrus Polymethoxyflavones, Nobiletin and its Analogues, on Acetylcholinesterase Activity
- The Roles of Aquaporins in Inflammatory and Ischemic Diseases
- Cellular and Physiological Functions of Phosphoinositide-Metabolizing Enzymes
- Hypoxic Stress Induces Transient Receptor Potential Melastatin 2 (TRPM2) Channel Expression in Adult Rat Cardiac Fibroblasts
- Effect of heterozygous deletion of WNK1 on the WNK-OSR1/SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels
- Inhibitory Effect of Cibenzoline on Na^+/Ca^ Exchange Current in Guinea-Pig Cardiac Ventricular Myocytes
- Inhibitory effect of β-hydroxybutyric acid on L-type Ca^{2+} current under β-adrenergic stimulation in guinea pig Cardiac ventricular myocytes
- EFFECT OF ORAL L-ARGININE ADMINISTRATION ON EXHALED NITRIC OXIDE (NO) CONCENTRATION IN HEALTHY VOLUNTEERS
- Characterization of the activity of a platelet activating factor antagonist, CV-3988.
- Effects of KB-2796, a New Diphenylpiperazine Calcium Antagonist, on Renal Hemodynamics and Urine Formation in Anesthetized Dogs.
- Forefront of Na+/Ca2+ Exchanger Studies: Physiology and Molecular Biology of Monovalent Cation Sensitivities in Na+/Ca2+ Exchangers
- QUALITATIVELY DIFFERENT RESPONSE OF ISOLATED RABBIT AORTA TO METHYLENE BLUE ADMINISTERED FROM INTIMAL AND ADVENTITIAL SURFACE
- Quantitative Analysis and Cell Distribution Imaging of Phosphoinositides
- Mechanism of Statin-Induced Rhabdomyolysis
- Na+/Ca2+ Exchanger 1/2 Double-Heterozygote Knockout Mice Display Increased Nitric Oxide Component and Altered Colonic Motility
- A COMPARATIVE STUDY ON CONTRACTILE RESPONSES OF RABBIT AND GUINEA PIG VASA DEFERENTIA TO ELECTRICAL FIELD STIMULATION
- THE INHIBITORY EFFECT OF SHAKUYAKUKANZOTO ON K+ CURRENT IN H9c2 CELLS
- Upregulation of N-methyl-D-aspartate receptor subunits and c-Fos expressing genes in PC12D cells by nobiletin