Inhibitory Action of Troglitazone, an Insulin-Sensitizing Agent, on the Calcium Current in Cardiac Ventricular Cells of Guinea Pig
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概要
- 論文の詳細を見る
We investigated the effects of troglitazone, a new orally active hypoglycemic agent, on the voltage-dependent L-type Ca2+ current in single cardiac ventricular myocytes of guinea pigs by the whole-cell voltage clamp technique.Troglitazone blocked the Ca2+ currents in a concentration-dependent manner.The inhibitory effect was more potent at the holding potential(HP)of −50mV than at −80mV.The half-maximum inhibiting concentration(IC50)of troglitazone was 0.8μM with the Hill coefficient of 0.84 at −50mV HP.In contrast, the IC50 value was higher than 10μM at −80mV HP.These results suggest that troglitazone at therapeutic concentrations inhibit the Ca2+ channels and may exert cardioprotective effects in diabetic conditions.
- 社団法人 日本薬理学会の論文
- 2000-02-01
著者
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Kimura Junko
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Toho University
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WATANABE Tsuyoshi
Department of Cell Biology and Neuroscience, Osaka University Graduate School of Medicine
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HASHIMOTO Shigeatsu
Department of Internal Medicine III, Fukushima Medical University School of Medicine
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Kimura J
Fukushima Medical Univ. School Of Medicine Fukushima Jpn
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KATOH Yoko
Department of Internal Medicine III, Fukushima Medical University, School of Medicine
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Katoh Yoko
Department Of Cardiology Hiratsuka Kyosai Heart Center
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Katoh Yoko
Department Of Internal Medicine Iii Fukushima Medical University School Of Medicine
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Hashimoto Shigeatsu
Department Of Internal Medicine Iii Fukushima Medical University School Of Medicine
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Watanabe Tsuyoshi
Department Of Anatomy Ii Asahikawa Medical College
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Watanabe Tsuyoshi
Department Of Anatomy Asahikawa Medical University
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WATANABE Tsuyoshi
Department of Internal Medicine III, Fukushima Medical University, School of Medicine
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