Chronic Administration of Amiodarone Does Not Affect Na^+/Ca^<2+> Exchange Current in Guinea Pig Cardiac Ventricular Myocytes
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概要
- 論文の詳細を見る
We investigated chronic effects of amiodarone on Na+/Ca2+ exchange current (INCX) and on the level of Na+/Ca2+ exchanger (NCX1) mRNA in guinea pig ventricular myocytes using the whole-cell clamp technique and RT-PCR analysis, respectively. Guinea pigs were intraperitoneally injected with 80 mg/kg per day of amiodarone or the vehicle (saline) for 1 or 4 weeks. Single ventricular cells were isolated from the hearts of both groups of animals. Action potential duration at 90% repolarization level was prolonged to 143% and 165% of the control values by treatment with amiodarone for 1 and 4 weeks, respectively. INCX density and the level of NCX1 mRNA were not significantly changed by chronic treatment with amiodarone. The level of thyroid hormone (T4) within the blood was not changed by the treatments. These results suggest that chronic treatment with amiodarone does not affect the Na+/Ca2+ exchanger, with respect to the level of its mRNA and current density in guinea pig ventricular myocytes.
- 社団法人 日本薬理学会の論文
- 2002-09-01
著者
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Kimura Junko
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Toho University
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Wakabayashi Yasushi
Department of Medicine III, Hamamatsu University School of Medicine
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Kimura J
Dep. Of Pharmacology School Of Medicine Fukushima Medical Univ. Jpn
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Watanabe Yasuhide
Department of Basic Nursing, Hamamatsu University School of Medicine
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Watanabe Yasuhide
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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Watanabe Yasuhide
Department Of Pharmacology School Of Medicine Fukushima Medical University
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Kimura J
Department Of Pharmacology Fukushima Medical University School Of Medicine
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MATSUOKA Isao
Department of Pharmacology, Fukushima Medical University, School of Medicine
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Matsuoka Isao
Department Of Pharmacology Fukushima Medical College
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Wakabayashi Yasushi
Department Of Pharmacology School Of Medicine Fukushima Medical University
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Matsuoka Isao
Department Of Anesthesiology Ilikai Medical Inc Kakizoe Hospital
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