Effect of KB-2796, a New Diphenylpiperazine Ca2+ Antagonist, on Glutamate-Induced Neurotoxicity in Rat Hippocampal Primary Cell Cultures.
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概要
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The effects of the novel calcium channel antagonist KB-2796, other calcium channel antagonists, an <I>N</I>-methyl-D-aspartate (NMDA)antagonist, non-NMDA antagonists, Mg<SUP>2+</SUP>, a Ca<SUP>2+</SUP> -chelator and a calcium channel agonist on neurotoxicity induced by a 10-min application of 100μM glutamate were studied in rat hippocampal primary cell cultures. KB-2796 (0.1 and 1 μM), flunarizine (1 μM), nimodipine (10 μM), MK-801 (0.01-1 μM), Mg<SUP>2+</SUP> (10 mM)and EGTA (10 mM)significantly prevented the neurotoxicity, but 6-cyano-7-nitro-quinoxalinedione (CNQX)(10 μM)and 6, 7-dinitro-quinoxalinedione (DNQX)(10 μM)did not. Bay K 8644 (10 and 100 nM)enhanced the neurotoxicity. These findings indicate that KB2796 protects the neuronal cell from the glutamate-induced neurotoxicity, presumably by blocking the Ca<SUP>2+</SUP> influx into brain neurons.
- 公益社団法人 日本薬理学会の論文
著者
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Hara Hideaki
Department Of Biofunctional Evaluation Molecular Pharmacology Gifu Pharmaceutical University
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Yokota Koichi
Department Of Dermatology Hakodate Central General Hospital
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Sukamoto Takayuki
Department Of Pharmacology Jichi Medical School
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Shimazawa Masamitsu
Department Of Biofunctional Evaluation Molecular Pharmacology Gifu Pharmaceutical University
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Yokota Koichi
Department of Pharmacology, New Drug Research Laboratories, Kanebo Ltd.
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Shimazawa Masamitsu
Department of Pharmacology, New Drug Research Laboratories, Kanebo Ltd.
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