Effect of KB-2796, a New Diphenylpiperazine Ca2+ Antagonist, on Glutamate-Induced Neurotoxicity in Rat Hippocampal Primary Cell Cultures.
スポンサーリンク
概要
- 論文の詳細を見る
The effects of the novel calcium channel antagonist KB-2796, other calcium channel antagonists, an <I>N</I>-methyl-D-aspartate (NMDA)antagonist, non-NMDA antagonists, Mg<SUP>2+</SUP>, a Ca<SUP>2+</SUP> -chelator and a calcium channel agonist on neurotoxicity induced by a 10-min application of 100μM glutamate were studied in rat hippocampal primary cell cultures. KB-2796 (0.1 and 1 μM), flunarizine (1 μM), nimodipine (10 μM), MK-801 (0.01-1 μM), Mg<SUP>2+</SUP> (10 mM)and EGTA (10 mM)significantly prevented the neurotoxicity, but 6-cyano-7-nitro-quinoxalinedione (CNQX)(10 μM)and 6, 7-dinitro-quinoxalinedione (DNQX)(10 μM)did not. Bay K 8644 (10 and 100 nM)enhanced the neurotoxicity. These findings indicate that KB2796 protects the neuronal cell from the glutamate-induced neurotoxicity, presumably by blocking the Ca<SUP>2+</SUP> influx into brain neurons.
- 公益社団法人 日本薬理学会の論文
著者
-
Hara Hideaki
Department Of Biofunctional Evaluation Molecular Pharmacology Gifu Pharmaceutical University
-
Yokota Koichi
Department Of Dermatology Hakodate Central General Hospital
-
Sukamoto Takayuki
Department Of Pharmacology Jichi Medical School
-
Shimazawa Masamitsu
Department Of Biofunctional Evaluation Molecular Pharmacology Gifu Pharmaceutical University
-
Yokota Koichi
Department of Pharmacology, New Drug Research Laboratories, Kanebo Ltd.
-
Shimazawa Masamitsu
Department of Pharmacology, New Drug Research Laboratories, Kanebo Ltd.
関連論文
- Microarray analysis of the liver in metallothionein-III null mice treated with cadmium
- Microarray analysis of the liver in metallothionein-III null mice treated with cadmium
- Resistance of metallothionein-III null mice to cadmium-induced acute hepatotoxicity
- Phosphatidylinositol Inhibits Vascular Endothelial Growth Factor-A-Induced Migration of Human Umbilical Vein Endothelial Cells
- A unique monoclonal antibody 29A stains the cytoplasm of amniotic epithelia and cutaneous basement membrane
- Possible role of endoplasmic reticulum stress in the pathogenesis of Darier's disease
- Tyrosinase gene analysis in Japanese patients with oculocutaneous albinism
- Antihypertensive Effects of Flavonoids Isolated from Brazilian Green Propolis in Spontaneously Hypertensive Rats
- 1,1-Diphenyl-2-picrylhydrazyl Radical Scavenging Activity of Bee Products and Their Constituents Determined by ESR
- Regulation of ER molecular chaperone prevents bone loss in a murine model for osteoporosis
- Lig-8, a Bioactive Lignophenol Derivative From Bamboo Lignin, Protects Against Neuronal Damage In Vitro and In Vivo
- Vitreous Fluid Levels of β-Amyloid_ and Tau in Patients with Retinal Diseases
- Effect of Cerebral Arterial Occlusion on Cerebral Perivascular Innervation: A Histochemical and Immunohistochemical Study in the Rat
- Agarwood Induced Laxative Effects via Acetylcholine Receptors on Loperamide-Induced Constipation in Mice
- Histochemical Studies on Postnatal Development of Mice Irises and Cerebral Arteries
- Inhibitory Effect of Lomerizine, a Diphenylpiperazine Ca^-Channel Blocker, on Ba^ Current through Voltage-Gated Ca^ Channels in PC12 Cells
- Effects of Timolol-Related Ophthalmic Solutions on Cultured Human Conjunctival Cells
- Identification of mRNA-Rich Keratinocytes in the Basal/Suprabasal Layers of Psoriatic Skin
- Hailey-Hailey disease with affective disorder : Report of a case with novel ATP2C1 gene mutation
- Laxative Effect of Agarwood Leaves and Its Mechanism
- Fluorescence Investigation of the Retinal Delivery of Hydrophilic Compounds via Liposomal Eyedrops
- EFFECTS OF β-ADRENERGIC BLOCKING DRUGS IN HYPERTENSIVE RATS
- Effects of KB-5492, a New Anti-Ulcer Agent, on Ethanol- and Acidified Aspirin-Induced Gastric Mucosal Damage In Vivo and In Vitro.
- Effect of KB-2796, a New Diphenylpiperazine Ca2+ Antagonist, on Glutamate-Induced Neurotoxicity in Rat Hippocampal Primary Cell Cultures.
- Phosphatidylinositol Inhibits Vascular Endothelial Growth Factor-A- Induced Migration of Human Umbilical Vein Endothelial Cells
- Effects of KB-2796, a New Diphenylpiperazine Calcium Antagonist, on Renal Hemodynamics and Urine Formation in Anesthetized Dogs.
- Effects of the New Anti-Ulcer Agent KB-5492 on Experimental Gastric Mucosal Lesions and Gastric Mucosal Defensive Factors, as Compared to Those of Teprenone and Cimetidine.
- 4-Methoxyphenyl 4-(3,4,5-Trimethoxybenzyl)-1-Piperazineacetate Monofumarate Monohydrate (KB-5492), a New Anti-Ulcer Agent with a Selective Affinity for the Sigma Receptor, Prevents Cysteamine-Induced Duodenal Ulcers in Rats by a Mechanism Different from T
- Effect of nimodipine on ischemia-induced brain edema and mortality in a novel transient middle cerebral artery occlusion model.