Antioxidant and Immuno-Enhancing Effects of Echinacea purpurea(Pharmacology)
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概要
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We studied the protective effects of Echinacea purpurea against radiation by evaluating changes in the peripheral blood cell count and peripheral blood antioxidant activity. E. purpurea administration had a suppressive effect on radiation-induced leukopenia, especially on lymphocytes and monocytes, and resulted in a faster recovery of blood cell counts. Mouse peripheral blood antioxidant activity was increased by E. purpurea, and a relationship between the suppressive effect on radiation-induced leukopenia and the antioxidant effect was suggested. Furthermore, we reviewed the evidence of augmentation of found in this study humoral immunity. The effecst of immune activation by E. purpurea were investigated by measuring total immunoglobulin (IgG, IgM). The radio-protective effects of immune activation by E. purpurea were investigated by measuring T lymphocyte subsets in the peripheral blood of mice following whole-body irradiation. E. purpurea activates macrophages to stimulate IFN-γ production in association with the secondary activation of T lymphocytes, resulting in a decrease in IgG and IgM production. Cytokines released from macrophages in mouse peripheral blood after E. purpurea administration activated helper T cells to proliferate. In addition, it is reported that activated macrophages in association with the secondary T lymphocyte activation increases IFN-γ production and stimulates proliferation of cytotoxic T cells and suppressor T cells. We think that CD 4 and CD 8 subsets were more immunologically enhanced by E. purpurea than helper T cells and suppressor T cell these results reflect activation. In addition, we think that these results reflect cell-mediated immune responses.
- 公益社団法人日本薬学会の論文
- 2004-07-01
著者
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Ishida Torao
Hitech Research Center Suzuka University Of Medical Science
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INOUE Makoto
Faculty of Pharmaceutical Sciences, Nagoya City University
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GU Yeunhwa
Suzuka Univ.
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MARUYAMA Hiroe
API Company Limited Research Institute
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MISHIMA Satoshi
API Company Limited Research Institute
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Gu Yeunhwa
Suzuka Univercity Of Medical Science Graduate School Of Health Science
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Maruyama Hiroe
Api Co. Ltd. Nagaragawa Research Center
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Mishima Satoshi
Api Co. Ltd. Nagaragawa Research Center
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SAITO Kiyoto
Suzuka Univercity of Medical Science Graduate School of Health Science
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YAMASHITA Takenori
Suzuka Univercity of Medical Science Graduate School of Health Science
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Yamashita T
Suzuka Univercity Of Medical Science Graduate School Of Health Science
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Inoue Makoto
Faculty Of Pharmaceutical Science Nagoya-city University
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Inoue Makoto
Faculty Of Agriculture Miyazaki University
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