Identification of AMP N_1-Oxide in Royal Jelly as a Component Neurotrophic toward Cultured Rat Pheochromocytoma PC12 Cells
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概要
- 論文の詳細を見る
An extract of royal jelly (RJ) induced processes from cultured rat pheochromocytoma PC12 cells. Active components were isolated, and identified as adenosine monophosphate (AMP) and AMP N1-oxide. AMP N1-oxide was more than 20 times as active as AMP, judging from the minimal concentration to elicit activity. AMP N1-oxide was thought to be responsible for about half of the process-forming activity of whole RJ. Chemically-synthesized AMP N1-oxide was active similarly to the molecule purified from RJ, confirming AMP N1-oxide as the active entity. AMP N1-oxide also suppressed proliferation of PC12 cells and stimulated expression of neurofilament M, a specific protein of mature neurons, demonstrating the stimulatory activity of AMP N1-oxide to induce neuronal differentiation of PC12 cells. Pharmacological experiments suggested that AMP N1-oxide actions are mediated by adenyl cyclase-coupled adenosine receptors, including A2 A. Thus AMP N1-oxide is a key molecule that characterizes RJ, and is not found in natural products other than RJ.
- 社団法人 日本農芸化学会の論文
- 2006-04-23
著者
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Goto M
Laboratory Of Pharmaceutical Analytical Chemistry Gifu Pharmaceutical University
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Nomoto Hiroshi
Laboratory Of Molecular Biology Gifu Pharmaceutical University
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HATTORI Noriko
Laboratory of Molecular Biology, Gifu Pharmaceutical University
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MISHIMA Satoshi
Nagaragawa Research Center, API Co., Ltd.
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INAGAKI Shinsuke
Laboratory of Pharmaceutical Analytical Chemistry, Gifu Pharmaceutical University
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GOTO Masashi
Laboratory of Pharmaceutical Analytical Chemistry, Gifu Pharmaceutical University
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SAKO Magoichi
Laboratory of Medicinal Informatics, Gifu Pharmaceutical University
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FURUKAWA Shoei
Laboratory of Molecular Biology, Gifu Pharmaceutical University
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INAGAKI Shinsuke
Gifu Pharmaceutical University
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GOTO Masashi
Gifu Pharmaceutical University
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SAKO Magoichi
Gifu Pharmaceutical University
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Goto Masashi
Laboratory Of Pharmaceutical Analytical Chemistry Gifu Pharmaceutical University
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Inagaki Shuichiro
Aburahi Laboratories Shionogi & Co. Ltd.
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Sako Magoichi
Laboratory Of Medicinal Informatics Gifu Pharmaceutical University
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Hattori Noriko
Laboratory Of Molecular Biology Gifu Pharmaceutical University
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Furukawa Shoei
Laboratory Of Molecular Biology Gifu Pharmaceutical University
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Mishima Satoshi
Nagaragawa Res. Center Api Co. Ltd.
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Inagaki Shinsuke
Laboratory Of Pharmaceutical Analytical Chemistry Gifu Pharmaceutical University
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