In Vitro Studies of Cytotoxic Effect on Sarcoma-180 Cells of β-Subunit from Egg White Ovomucin
スポンサーリンク
概要
- 論文の詳細を見る
When sarcoma-180 (SR-180) cells were incubated with α- or β-subunit prepared from insoluble ovomucin in the gel fraction of egg white, the cell proliferation rate was apparently reduced by the addition of β-subunit, while it was largely unaffected by α-subunit. Examinations by scanning and transmission electronmicroscopy indicated a dose- and time-dependent cytotoxic effect of β-subunit on SR-180 cells, whereas β-subunit did not injure mouse peritoneum macrophage used as normal cells. Ultrastructurally, SR-180 cells treated with β-subunit showed changes such as swelling and bleb formation of microvilli on cell membrane, irregular clumping of chromatin, irregular nuclear shape, and marked swelling of organelles in cytoplasm associated with cell degeneration in necrotic change. Furthermore, apoptotic analysis of the cultured SR-180 cells also demonstrated that β-subunit did not induce the apoptotic DNA fragmentation.
- 社団法人 日本食品科学工学会の論文
- 1999-08-01
著者
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YOKOTA Takashi
Department, of Information Science, Graduate School of Engineering, Utsunomiya University
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Yokota Takashi
Department Of Pathology Institute Of Gerontology Nippon Medical School
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WATANABE Kenji
Faculty of Pharmaceutical Sciences, Fukuoka University
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OHISHI Hifumi
Fundamental Research Laboratory, Kyodo Milk Industry Co., Ltd.
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Ohishi Hifumi
Fundamental Research Laboratory Kyodo Milk Industry Co. Ltd.
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Watanabe Kensuke
Ichimaru Pharcos Co. Ltd.
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Yokota Takashi
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Hoshi University
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Watanabe Kenji
Faculty Of Fisheries Kagoshima University
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WATANABE Kenji
Faculty of Agriculture, Gifu University
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