Interaction between 120kDa Fragment in β-Subunit from Egg White Ovomucin and Sarcoma-180 Cells through Basic Fibroblast Growth Factor Receptor
スポンサーリンク
概要
- 論文の詳細を見る
The mechanism of antitumor activities in hen egg white ovomucin (OVM) was analyzed by examining the interaction between the 120 kDa fragment (a highly glycosylated fragment in β-subunit from the pronase-treated OVM) and basic fibroblast growth factor receptor (bFGFR). The 120 kDa fragment, which was transblotted onto a polyvinylidene difluoride membrane after SDS-polyacrylamide gel electrophoresis, was found to interact with bFGFR. The interaction was detected by Western blotting method with mouse anti-FGFR IgM. When sarcoma-180 (SR-180) cells were cultured on addition of the 120 kDa fragment, they were observed to be in the necrotic state by transmission electron microscopy, and the 120 kDa fragment was seen to be dispersed on the cell surface by light and transmission electron microscopic observations with the immunocytochemical staining method. The growth of SR-180 cell in the presence of bFGF was reduced with increase in the amount of 120 kDa fragment added. Thus, it was found that the 120 kDa fragment interacted with SR-180 cells through bFGFR and affected them.
- 社団法人 日本食品科学工学会の論文
- 2000-11-01
著者
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YOKOTA Takashi
Department, of Information Science, Graduate School of Engineering, Utsunomiya University
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Yokota Takashi
Department Of Pathology Institute Of Gerontology Nippon Medical School
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TANI Hisanori
Fundamental Research Laboratory, Kyodo Milk Industry Co., Ltd.
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OHISHI Hifumi
Fundamental Research Laboratory, Kyodo Milk Industry Co., Ltd.
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OGURO Tatsuo
The United Graduate School of Agricultural Science, Gifu University
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WATANABE Kenji
The United Graduate School of Agricultural Science, Gifu University
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Ohishi Hifumi
Fundamental Research Laboratory Kyodo Milk Industry Co. Ltd.
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Tani Hisanori
Fundamental Research Laboratory Kyodo Milk Industry Co. Ltd.
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Tani Hisanori
Department Of Food Science And Technology School Of Agriculture Nagoya University
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Watanabe Kensuke
Ichimaru Pharcos Co. Ltd.
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Yokota Takashi
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Hoshi University
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Oguro Tatsuo
The United Graduate School Of Agricultural Science Gifu University
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Watanabe Kenji
The United Graduate School Of Agricultural Science Gifu University
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