Generation of Radical Species from Dihydropyrazines Having DNA Strand-Breakage Activity and Other Characteristics

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概要

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• The various biological activity of dihydropyrazines(DHPs)due to the radical generation potency has been described in previous papers. Detailed data about radical species generating be mentioned here. The electron spin resonance (ESR) spin-trapping technique revealed that DHPs generate free radical species such as ·OH, ·OOH, ·CHR2 and ·CR3. Oxygen radicals and two carbon-centered radicals were detected as adducts of the spin traps DMPO and DBNBS, respectively. All the 5,5-dimethyl-1-pyrroline-N-oxide (DMPO)- and 3,5-dibromo-4-nitrosobenzenesulfonate (DBNBS)-adducts of compounds DHP-1–8 exhibited approximately the same signal patterns, with various levels of intensity depending on the substituent of the dihydropyrazine ring. The ESR signal intensity of DHPs also increased remarkably upon addition of Cu2+, resulting that the effects of DHPs were enhanced.

• 公益社団法人　日本薬学会の論文

著者

• Kansui Hisao

  Faculty Of Pharmaceutical Sciences Sojo University

• MATSUMOTO Shigenobu

  Department of Biochemistry and Isotope, Tokyo Metropolitan Institute of Gerontology

• Takeshita Keizo

  Faculty Of Pharmaceutical Sciences Sojo University

• Tadatoshi Yamaguchi

  Faculty Of Hygiene Miyazaki Medical College

• Kunieda Takehisa

  Faculty Of Pharmaceutical Sciences Kumamoto University

• Ishida Takumi

  Faculty Of Pharmaceutical Sciences Sojo University

• Takechi Shinji

  Faculty of Pharmaceutical Science, Sojo University

• Yamaguchi Tadatoshi

  Faculty of Pharmaceutical Science, Sojo University

• Masumizu Toshiki

  Faculty of Pharmaceutical Sciences, Sojo University

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